Nestled on the banks of the Clyde River, overlooking Vermont’s widely reputed lush, forested hills sits Poulin Grain. Proud to call Vermont home since 1932, this fourth-generation family-owned business offers personalized service — including one-on-one animal nutrition consultations, lab-based forage analysis and customized recommendations — along with the manufacturing and delivery of premium animal feeds. Poulin Grain’s diverse customer base includes livestock producers and animal enthusiasts throughout the eastern U.S. and Canada.

As noted by company president Josh Poulin, the nearly 90-year-old business “[has] always been committed to delivering high-quality animal nutrition products at a fair value, and taking care of [its] people, animals and customers.”  

Based in Newport, Vermont, Poulin Grain serves a wide range of customers throughout the eastern U.S. and Canada, including many dairy producers.

Managing mycotoxins in feed and forage

Poulin Grain maintains a steadfast focus on serving the animal and meeting their requirements, which is why they are consistently exploring new technologies that can help them implement superior quality control and produce animal feeds of only the highest caliber.

The company’s northeastern U.S. location — a region often referred to as “mycotoxin central” — led to them initially building a relationship with Alltech. The two companies worked together to implement a mycotoxin control program at Poulin’s mills while also helping their nutrition teams and customers understand more about this dynamic problem on-farm, which includes a central focus on enhancing forage quality.

Why mycotoxin testing is necessary

A 2021 study from Weaver et al. highlighted the prevalence of these toxic compounds in U.S. corn grain and corn silage by analyzing the results of almost 2,000 grain and forage samples across seven years. Findings showed that the mean numbers of mycotoxins per sample were 4.8 and 5.2 in grain and silage, respectively.

These findings are often replicated in the ongoing testing carried out by Alltech’s 37+^® mycotoxin analysis laboratory network. For example, in 2021, over 7,000 tests revealed that an astounding 95% of samples contained two or more mycotoxins.

In recent years, several factors have combined to exacerbate the mycotoxin risk in animal diets worldwide. More extreme weather patterns, such as droughts and floods, are creating extra stress on crops, which is one of the primary predisposing factors for mold and mycotoxin development. Additionally, the shift to no-till crop establishment and reduced crop rotation is leading to a greater buildup of crop residues, which only serves to increase the mycotoxin risk in subsequent crops.

How mycotoxins impact animals

Mycotoxins can be the root cause of numerous problems on-farm. However, some of the more common mycotoxin symptoms include:

• Digestive disorders, such as diarrhea.
• Reproductive challenges, such as decreased fertility and abnormal estrous cycles.
• Reduced animal performance, often linked to reduced feed consumption and nutrient utilization.
• Compromised health, related to suppressed immunity and increased disease risk.

As demonstrated by the routine mycotoxin analysis mentioned above, the presence of multiple mycotoxins in grains and forages tends to be the norm rather than the exception. This may lead to additional or synergistic effects, further compounding the mycotoxin problem for livestock producers.

Taking a proactive approach to mycotoxin management

Although mycotoxins are often chemically stable enough to survive food and feed processing — meaning it is virtually impossible to eliminate them from the supply chain — there are some key steps that can be taken to enhance control efforts.

John Winchell serves as Alltech’s Northeast U.S. territory sales manager, where he has worked with Poulin Grain for nearly two years. When working through mycotoxin challenges, John has always believed it’s best to take a more proactive approach.

“When you think of mycotoxin management, I think it’s much more than just a product — it’s a program; [one that involves] looking at pre-harvest and post-harvest strategies, and [considering] different things, such as climate, population, and varieties,” John explains. “[This paints] a total picture as opposed to [taking a] reactive [approach].”

Aided by Winchell’s support throughout the crop-growing season, Poulin Grain and their dairy nutrition customers have implemented steps to help enhance forage quality and produce superior quality dairy feeds.

For example, to manage grain and forage quality post-harvest, John introduced Poulin Grain to both the Alltech 37+ mycotoxin analysis and Alltech RAPIREAD^®.

Alltech 37+ is a lab-based mycotoxin detection method that can identify up to 54 individual mycotoxins, including those in total mixed rations (TMRs).

Alltech RAPIREAD utilizes a portable testing module to quickly detect six key mycotoxins. It is typically used directly on-farm or in the feed mill due to its ability to deliver quick results, often in less than 15 minutes.

“Working with [Alltech] 37+ to look at the different samples on different commodities and forages has really helped us get closer to where we need to be on forage quality and cow health,” states Winchell, while also highlighting how Poulin Grain were early adopters of Alltech RAPIREAD, thereby allowing mycotoxin control decisions to be activated on the same day that a challenge is identified.

Optimizing dairy forage quality is a key focus area for both Poulin Grain and Alltech.

Maximizing livestock productivity

Poulin Grain is no stranger to adaption and innovation, as noted by general manager and senior vice president Mike Tetreault, “One of the key things for Poulin Grain to continue to be leaders in animal nutrition is we must be innovative. And part of being innovative for us is having the right products, services and technologies [in place].” That is where John Winchell and Alltech come in.

According to Tetreault, “[Winchell] has been a tremendous asset for us — he’s been really committed [to serving] all our customers and covering every area. He’s been a true source of support, education and growth for all our customers and [our] company. I don’t know what we’d do without this Alltech service.”

From starting with a simple introductory webinar to today implementing the latest in mycotoxin detection, Mike feels the Poulin team has now become experts in managing mycotoxins and is far more able to make informed decisions.

What lies ahead

As Poulin Grain’s business continues to grow and develop the ways in which it serves its diverse customer base, Tetreault is excited about what lies ahead.

“When we find problems that really need further investigation, Alltech’s 37+ [program] has been there to support us dramatically for the last year,” he says. “We’ve had several situations where we’ve been able to help and correct management [on-farm]. It’s really been a great run, and I know that going forward, utilizing these Alltech services, products and technologies will [continue to] truly be an asset for Poulin Grain.”

Yeast supplementation is a common practice to improve the efficiency of feed utilization and performance in dairy cows. It is well-known that supplements containing live yeast can improve rumen fermentation and the digestive process by stabilizing rumen pH and stimulating the growth of beneficial microbial populations. These positive changes can be attributed to growth factors, including peptides, and the effect on the rumen anaerobiosis to create optimal conditions for the rumen microflora.

Good rumen function will ensure optimal feed intake and digestive efficiency in dairy cows, while poor rumen function can negatively impact feed intake, health and overall cow performance. Formulating the ration correctly and understanding how the individual ingredients in the ration work together can help keep the dairy cow’s rumen and digestive system functioning properly.

How can you ensure that good formulations will lead to the expected results?

Published research and decades of use in the field suggest that most dairy diets respond positively to Yea-Sacc^®, a yeast culture based on Saccharomyces cerevisiae that stimulates the growth of fiber-digesting and lactic acid-utilizing bacteria in the rumen. These microbial changes directly result in:

• A stable rumen pH, which is conducive to better fiber digestion and a reduced risk of rumen acidosis
• Improved feed intake
• Enhanced milk yield and components

However, not all formulation strategies react the same way. As a result, there may be instances in which supplementation with Yea-Sacc does not yield the expected results.

To quantify the efficacy of Yea-Sacc for improving rumen fermentation and nutrient utilization for specific dairy TMRs, allowing for greater precision when feeding Yea-Sacc, Alltech created the Alltech IFM™: Yea-Sacc^® Value Test (YSVT^®).

The response of dairy TMRs to Yea-Sacc supplementation may vary depending on the feedstuffs. Formulation models are limited in predicting the effects of non-nutritive feed additives on rumen fermentation, which limits the precision of ration formulation and the prediction of the efficacy of a given additive. A quick lab-based test that evaluates the potential of Yea-Sacc in a particular situation can help improve the nutritive value of a given TMR.

Building on Alltech IFM, an in vitro rumen fermentation model used to characterize feed digestion kinetics, YSVT is a unique approach to rumen fermentation analysis. Standard in vitro rumen simulation techniques are usually conducted over a shorter period spanning 48 to 72 hours of fermentation. As a result, these techniques do not allow for an accurate evaluation of the efficacy of yeast supplements, as the effects of yeast on rumen populations are not readily evident until supplements like Yea-Sacc have been included in the diet for at least 4 to 7 days.

As the animal adapts to the presence of Yea-Sacc in its diet, the rumen microbial population changes to comprise higher concentrations of fiber-digesting and lactate-utilizing bacteria. YSVT utilizes rumen fluid both from animals that have been adapted to Yea-Sacc and their counterparts that are fed the same basal ration without Yea-Sacc. This allows for the adequate adaptation of the rumen microbial populations to Yea-Sacc without the need for long-term incubation in the lab.

The YSVT test measures key fermentation indicators, including:

• Digestibility
• Lactic acid concentration
• Useful energy (i.e., energy produced from the fermentation of carbohydrates)
• Rumen energy efficiency (i.e., useful energy per pound of feed digested)

To date, more than 200 dairy TMRs have been analyzed using YSVT. More than 93% of the samples showed a positive response to Yea-Sacc supplementation in terms of useful energy and rumen energy efficiency, with an average response of +13%.

In approximately 50% of all samples, the increase in the useful energy released was not correlated with improvements in digestibility. This indicates that Yea-Sacc increases the efficiency by which feed nutrients are converted into useful energy for the animal, most likely through a more efficient and healthier microbiome. The lactic acid response was more variable, with more than 60% of the samples showing decreased concentration, indicating a reduced risk for a lower rumen pH and acidosis.

In conclusion, the YSVT helps nutritionists and producers understand the value of yeast in improving rumen fermentation. As a result, feed additive supplementation strategies can be tailored to maximize the energy produced from rumen fermentation and improve digestive efficiency in dairy cows.  future developments of this tool will focus on better understanding the interaction of ingredients, the nutrient composition of the TMR and the response to Yea-Sacc — and on developing predictive models to quantify the expected animal performance based on the outcome of a given fermentation profile.

I would like to learn more about the Yea-Sacc Value Test.

The receiving period can be a stressful time for cattle. Recently, during the Alltech ONE Ideas Conference, Dr. Carlo Sgoifo Rossi gave a presentation titled “Receiving With Ease: Minimizing Stress During the Adaptation Phase.” Dr. Sgoifo Rossi is currently an associate professor in the department of veterinary science and technology for food safety at the State University of Milan. Utilizing his perspective and knowledge of the European beef production system, Dr. Sgoifo Rossi shared some information about the various considerations related to stress and adaptation that producers should keep in mind when implementing feeding programs and management practices.

When cattle are undergoing a transition like weaning and receiving, they experience stressors, including:

• Transportation
• Interactions with other cattle
• Interactions with humans
• Changes in nutrition

These stressors can have a major impact on cattle and can lead to such issues as changes in their immunodeficiency, reduced rumen motility, altered nutrient absorption, increased nutrient requirements and an upsurge of mineral excretion by the kidneys.

Receiving stress can lead to BRD

Regarding immune function, one common but highly concerning issue is bovine respiratory disease (BRD), which can strongly affect the performance of cattle. As illustrated in Figure 1, cattle who arrive and are treated for BRD can exhibit a decrease in average daily gains. It is also important to understand that animals who experience BRD often produce meat with lower marbling and quality grades. Considering all of these factors, mitigating BRD is important not only for the animal’s quality of life but for the producer’s bottom line and the consumer’s satisfaction.

Appropriate sanitary conditions make a difference

While the health of newly arriving animals is impacted by their location of origin, it is also greatly affected by the sanitation and management of the receiving location. According to Dr. Sgoifo Rossi, “The type of vaccination, the type of antibiotics used (and) the type of anti-parasitic product can affect the sanitary conditions of our animals.” Dr. Sgoifo Rossi encouraged producers to approach sanitation with an understanding of their specific herd and facilities and posited that, for some beef production systems, the strategy of going “all-in and all-out with cleaning and disinfection” is the best approach.

Nutrition is critical in the cattle business

When talking about management, we must be sure to properly feed and rehydrate the cattle upon arrival. Ensuring that clean drinking water is readily available and being conscious of the arrival diet are both crucial. Feeding the arrival diets in small amounts multiple times a day is recommended, as this will reduce competition among the animals, giving each of them an opportunity to receive adequate amounts of protein and energy. Arriving cattle can sometimes be considered high risk, making this a critical period for helping them recover properly and get back to normal rumen functionality.

Studies have shown that the appropriate arrival diet should have a crude protein and dry matter composition of less than 13%.

“Several studies show that if we improve the crude protein level of adaptation diets or the energy level of adaptation diets, we increase not only the incidence of morbidity but also the severity of morbidity and, consequently, the risk of mortality,” Dr. Sgoifo Rossi said.

Additionally, with the arrival diet typically being richer in forage and higher in fiber, reducing the chop length of the fiber will also reduce the likelihood that animals will sort through the ration. This is important, because sorting can cause cattle to eat too much starch or protein, which can lead to fluctuations in the pH level.

Consider all of the nutritional needs of arriving cattle

Unsurprisingly, it is also important to consider the nutrients available in the arrival diet. Providing new-arrival animals with the proper nutrients will improve their immunity, digestibility, and energy and protein balances.

To recover rumen and immune system functionality in newly arrived cattle, it is important to consider diets that include the following:

• High levels of digestible fiber
• Yeast
• Mannan oligosaccharides (MOS)
• Slow-release nitrogen
• Vitamins
• Minerals

As mentioned previously, the arrival period is so critical for getting cattle right. Vitamins, minerals and other supplements can help improve their feed and can be fundamental in helping these cattle adapt to their new home. In his presentation, Dr. Sgoifo Rossi mentioned that studies have shown that organic zinc and selenium, live yeast and mannan oligosaccharides can be huge players in the reduction of morbidity and mortality in these potentially high-risk cattle.

Too often, producers and nutritionists underestimate the importance of these ingredients, leading to negative results. Dr. Sgoifo Rossi shared a study completed in Italy that examined the mineral status and mineral plasma levels of cattle after arrival. This trial focused on the evaluation of various mineral levels in the blood immediately after arrival. As shown in Figure 2, 83% of new-arrival beef cattle were in a deficient or sub-deficient condition regarding their copper availability, and 30% displayed deficient or sub-deficient zinc availability and reserves.

Weather can be a stressor

Weather can play a significant role in cattle stress, and more thoughtful management practices should be implemented with the weather in mind. Spring, summer and fall are less of a concern when it comes to sanitation management, but winter is a critical period for sanitation. Producers often forget to consider the relationship between temperature and humidity during the winter and how it can lead to cold stress. This can create a potentially dangerous environment for cattle and can result in increased incidences and more severe cases of BVD. As shown in Figure 3, low-temperature, high-humidity environments can create a risk area where sanitation conditions are an issue, leading to a slower adaptation for arriving animals.

As previously mentioned, there are challenges leading up to and during the receiving period that can result in the highest risks of morbidity and mortality. Implementing the proper sanitation and vaccination protocols, providing sick animals with antibiotics, being proactive about their nutrition, and understanding which management practices to use based on the origin of your cattle, as well as their transportation details and the time of year, are all effective ways to mitigate any potential challenges associated with receiving cattle.

I want to learn more about nutrition for my beef cattle.

No matter the segment of the beef system, stress is a natural and unavoidable hurdle that the beef industry must learn to manage. Ironically, it is often the segmentation of the beef system that results in periods of stress. These stressful times often fall around transition intervals, when cattle move from one phase of production to the next. Weaning and feedlot receiving are two transition periods during which calves will experience multiple stressors. Prolonged exposure to stress has negative impacts on calf performance, and these negative effects can result in long-term issues.

When you consider the long history of the beef sector, stress is a relatively new issue being examined and discussed by those in the industry. In recent years, scientists and producers have begun to realize the impact that stress can have on calf performance. Fortunately, however, there are solutions for mitigating stress for your cattle during transitions. First, it is important to understand what can cause stress, as well as the consequences of that stress.

Stressors that can occur during weaning and receiving include:

• Separation from the dam

The social stress of being removed from the mother can be significant. One management practice that gradually weans calves is fence-line weaning. This technique involves placing weaned calves and dams in adjacent pastures that allow calves to be able see their mothers while being physically separated. Make sure you have sturdy fences with no gaps to prevent calves from crawling through to the other side.

• Transportation

It’s inevitable: At some point, cattle will need to be moved. There are many ways that producers can work to reduce stress during transportation — but similarly to humans travelling to new locations or making a big move, this major transition will likely lead to schedule changes and disruptions, changes in eating patterns, etc.

• Commingling

When groups of cattle are mingled together, they can expose each other to new pathogens. Even if the animals are on the same ranch but are from different pastures, producers need to consider a commingling strategy.

• Unfamiliar diets

Going from their mothers’ milk to feed might feel like a stark transition to some calves. The tips later in this article explain how to get calves to the bunk and help them transition to a new, healthy, nutrient-dense diet.

Stress can have consequences on production, including:

• Impaired growth. Stress causes muscle breakdown and can slow the growth of your cattle.
• Suppression of immune functions, which can lead to a decreased ability to resist infection and an increased susceptibility to getting sick.
• Altered behavior, like reduced feed intake.

A wholistic view of beef production is necessary to identify where leverage points exist within the production system. Recognizing leverage points allows for a more effective application of management practices to minimize stress and improve performance. In beef production, the most effective approach to minimizing stress is a preventative one. Implement practices that will help you foster and maintain a resilient herd. Resilient calves are going to be able to handle the periods of stress that are inherent within the beef system. The key to building resilient calves is implementing proactive management practices.

Outlined below are five easy and practical management tips that will help you produce resilient cattle.

1. Vaccinate prior to shipping.

Work with your veterinarian to establish a vaccination program prior to your animals being commingled and shipped. A vaccination program is essential to building a healthy immune system prior to animals being exposed to novel pathogens in a new place and when surrounded by other animals.

2. Castrate animals as early as possible.

Castration is a stressful but generally necessary management practice. Research has shown that animals experience less stress when they are castrated at a younger age. Some producers will castrate at birth, when they tag or maybe when they take cattle out to grass. Whatever fits into your management schedule, getting your animals castrated early will allow them to recoup before other stressors manifest throughout the following transition stages.

3. Minimize commingling.

Just like with humans, anytime you bring animals from different sources together, you run the risk of exposing them to pathogens. You can reduce this risk of exposure for calves by being strategic about minimizing mixing between sources of cattle. There is also an element of social stress as the newly commingled animals work to establish a pecking order.

4. Expose calves to feed bunks and water troughs.

Familiarize your animals with feed bunks and water troughs prior to shipping. This can help reduce stress during feedlot arrival, as getting calves to feed bunks prior to shipping will help them get onto feed quicker. The sooner they get on feed and start consuming water, the better they will bounce back from transportation stress.

5. Proper nutrition is essential.

When transitioning cattle, it is important to make sure that their nutritional requirements are being met. Meeting the cattle’s protein, energy and trace mineral requirements is essential for their immune function and growth. During periods of stress, it is common for animals to reduce their feed intake. In these cases, providing diets that are more nutrient-dense to compensate for reduced intake is recommended.

It is unrealistic to think that we can eliminate all stress from the production system, but we can minimize the duration and severity of the stress that animals experience. When utilizing these management techniques, consider a schedule that exposes calves to stressors gradually, rather than all at once. When calves feel high levels of stress and no mitigation strategies are used, they can experience critical setbacks. The most important reason to help calves through periods of stress is to set them up for success for the rest of their life — ultimately leaving you with healthy animals, a healthy reputation and a healthy bottom line.  

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People interpret sustainability in different ways. Hence the uncertainty and divisiveness the topic can create in discussions. In contrast with other industries, the agri-food sector has the unique position of being a solution provider when it comes to mitigating emissions and supporting biodiversity in our local environments. Animal feed is integral to profitable and efficient dairy and beef farming. Therefore, feed production has a crucial role in how we lower the environmental impact associated with the food system.

Strengthening the links in our chain

COVID-19 has emphasized the need for such resilient food systems. Feed production capacity is directly correlated to the amount of food available for human consumption and, indeed, general food security. Alltech’s experience across 128 countries finds that sustainable and efficient feed supply chains are relevant to small-scale livestock production all the way up to some of the world’s largest integrators. A growing challenge for the feed industry is competition with humans for similar feed sources. This challenges the feed additive inclusion to improve rumen efficiency and exploration of bespoke feed ingredients that only ruminants can utilize. Sustainable animal feeding has and is being practiced. Through Alltech’s unique network of eight Alltech IFM™ (in vitro fermentation model) labs around the world, we can verify in greater detail diet efficiency and where scope exists to lower emissions and improve producer profitability. 

Can you verify that?

It is no longer sufficient to simply claim a low carbon footprint for your livestock production system or animal feed. This needs to be supported by repeatable, measurable and verifiable evidence. Alltech E-CO₂ has developed the Feeds EA™ model to help feed manufacturers and producers globally measure and lower the carbon footprint of their feed. Feeds EA measures the environmental impact of feed production at the feed mill level by assessing the effects of existing compounds or blends. This is determined by calculating greenhouse gas emissions from production, cultivation, processing, energy utilization and transportation in feed manufacturing. Feeds EA™ can calculate emissions from a database of more than 300 ingredients, including raw materials, soya products, byproducts and additives.  

In reducing food waste through circular agriculture-type initiatives, we can be confident about the resilience of our food production systems to embrace more efficient resource utilization. This is exemplified in initiatives such as supplementation of byproducts to ruminants and closing nutrient loops. By lowering food loss and waste in our livestock production systems in a verifiable way, we can continue to make a strong case for the sustainable solutions our industry offers in slowing the pace of climate change.

Mitigating waste

Precision agriculture and the application to animal nutrition has been proven in recent Alltech meta-analyses on dairy (Salami et al., 2021) and beef research (Salami et al., 2020) to lower environmental impact through improved nitrogen utilization in ruminant systems. Optigen® supplementation through dairy diets was shown to:

• Improve nitrogen utilization efficiency in dairy cattle by 4%, thanks to better nitrogen capture in the rumen.
• Reduce manure nitrogen excretion by 12–13 g of nitrogen/cow/day.

This data suggests, for example, that the use of Optigen could reduce the annual manure nitrogen excretion from the U.S. dairy sector by an average of 51,509 metric tons of nitrogen based on the annual milk output.

Simply put, this approach is trying to provide ‘the right amount of nitrogen, at the right time, in the right place’ to help in reducing waste on farms. Results from the meta-analysis also showed that the use of Optigen in dairy diets resulted in a carbon saving of around 54 g of CO₂e per kg of milk. When extrapolated to the annual milk output of the German dairy sector, for example, this would be equivalent to a carbon emission reduction of 1.8 million metric tons of CO₂e. Such a carbon saving represents 16% of the entire reduction target for German agriculture by 2030.

A simulation analysis based on the results of the meta-analysis indicated that feeding Optigen to 1,000 dairy cows would:

• Increase income over feed costs by $18,000.
• Reduce the carbon footprint of the herd by 647 metric tons of CO2e. That carbon reduction is the same as taking 424 cars off the road or 436 houses’ use of electricity.

The meta-analysis on beef research highlighted how the partial replacement of vegetable protein with Optigen exhibited a consistent improvement in the liveweight gain and feed efficiency of beef cattle. The many positive effects included an average higher liveweight gain (by 8%) and better feed efficiency (by 8%), with the inclusion of corn silage enhancing the effects of Optigen.

A simulation analysis based on these benefits indicated that feeding Optigen to gain 440 lbs. in 1,000 cattle would:

• Reduce the time to slaughter by 9 days.
• Reduce feed costs by $18,000.
• Support a reduction in the carbon footprint of the beef unit by 111 tons of CO₂e. That carbon saving is the same as taking 73 cars off the road or 75 houses’ use of electricity.

Sustainability does not have to come at a cost

Lowering the environmental impact from animal feed does not imply lowering revenues for food system stakeholders. From large dairy farms in the U.S. to the 300 million dairy cows predominantly spread across small farms in India, Alltech has firsthand experience of how sustainable solutions have become the non-negotiable in animal nutrition. Profitable farming understandably leads this agenda. With animal feed typically representing the most significant variable cost in producing animal products, there is a business responsibility to ensure we minimize food loss and waste.

Animal feed production has humbly underpinned the food system that has enabled global population growth over the last 150 years. It is now time to recognize this unique contribution and how it also serves in discovering and implementing technologies that lower the environmental impact of animal products and support the circular economy.

Considering sustainability efforts need to make both environmental and economic sense, don’t miss our related blog 6 tips to stretch protein supplies and lower your feed costs.

I want to learn more about ruminant production.

The pathology of cattle consuming endophyte-infected tall fescue varies greatly based on the weather and the alkaloid concentration. The most readily apparent signs of fescue toxicosis include reduced feed intake, weight gain, milk production and reproductive efficiency, as well as tissue necrosis and a rough hair coat. Decreases in productivity caused by fescue toxicosis are estimated to cost U.S. beef producers more than $2 billion annually (Kallenbach, 2015).

Absorption of alkaloids

Calculating the animal’s retention of ergot alkaloids is difficult due to biotransformation. Generally, it is estimated that 76–92% of consumed ergot alkaloids are absorbed, with the other 8–24% excreted in the feces. The math on alkaloid absorption and excretion doesn’t always add up, as alkaloids are broken down and/or biotransformed into numerous metabolites. Most alkaloids are ultimately excreted in the urine as lysergic acid.

Fescue alkaloids and microbiome shifts

An emerging area of research is the interaction between fescue alkaloids and the microbiome. Decreases in the Erysipelotrichaceae family and increases of Ruminococcaceae, Lachnospiraceae and Clostridiaceae, as well as abundances of Planctomycetes, Chloroflexi and Proteobacteria phyla have been reported for cattle grazing infected fescue. Fescue seed extract, when added to in vitro fermentations, led to increased populations of tryptophan-utilizing bacteria. Considering the tryptophan base of ergot alkaloids, this increase likely indicates an up-regulation in detoxification capacity. The characterization and identification of the three isolates with the highest conversion abilities found that all three were gram-positive, spore-forming rods that produced ammonia from tryptophan, classified as Clostridium sporogenes.

Receptor-binding of fescue ergot alkaloids

Due to the structural similarity of ergot alkaloids and serotonin, dopamine, norepinephrine and epinephrine, several receptor types in numerous tissues are affected during fescue toxicosis in cattle. This results in a wide range of effects on physiology and metabolism. As more research examining the underlying mechanisms is completed, the connections between ergot alkaloid receptor-binding and animal performance grow more complex.

Individual animal sensitivity to infected fescue is affected by:

• Environmental conditions.
• The density of the receptors.
• The capacity for liver and ruminal degradation.
• Other genetic factors.

Fescue's effect on weight gains

Ergot alkaloid-induced vasoconstriction reduces heat dissipation, resulting in a variety of physiological fescue toxicosis symptoms in cattle, including an increased respiration rate and elevated core body temperature. Ultimately, this leads to lower weight gains — which is generally known as the summer slump, as animals spend less time grazing as a result of standing in the shade or water to cool off. In colder months, fescue-associated vasoconstriction combines with thermoregulatory vasoconstriction, resulting in tissue death in the extremities, which is commonly known as fescue foot.

Ergot alkaloid consumption also leads to:

• The thickening of the medial layer of blood vessels
• Endothelial cell damage
• Vascular stasis
• Thrombosis
• Ischemia
• Changes in blood pressure, among other cardiovascular effects

Fescue's effect on rumen fill

The frequency and amplitude of the ruminal contractions, as well as changes in eating patterns due to fescue toxicosis in cattle, combine to affect rumen fill, passage rates and intake.

• Vasoconstriction also reduces blood flow to the rumen, decreasing VFA absorption.
• Increased rumen fill provides a negative feedback loop, exacerbating reduced intakes.
• While the total tract digestibility of the feeds is generally unchanged, these alterations work in concert to reduce nutrient availability, contributing to the reduced growth rate frequently observed in cattle grazing fescue.
• Added to this are the effects of alkaloids on circulating serotonin levels, the hypothalamic center and tryptophan-related satiety.

Fescue's effect on energy metabolism

Ergot alkaloids affect energy metabolism primarily when alkaloid intakes are high and during heat stress. Growth differences in cattle during fescue toxicosis are most likely the result of reduced intake, as no differences in retained energy or energy partitioning were caused by alkaloid ingestion when feed intake was equal.

• When fed near maintenance, cattle had lower basal metabolic rates.
• At higher feeding rates, maintenance energy requirements increased.
• When combined with observed increases in fat loss and a higher capacity for gluconeogenesis in the liver, this indicates the prioritization of energy (when available) toward elevated respiration, thermoregulation and alkaloid detoxification.

Economic losses due to fescue toxicosis

As much as 75% of the economic losses attributed to infected tall fescue pastures are related to decreased calving rates.

For cows:

• Alkaloid consumption reduces the circulating levels of several hormones important for reproductive efficiency, including progesterone and estradiol.
• Changes in ovarian follicle development, oocyte quality and luteal function have been reported.
• When combined with vasoconstriction to the uterus and ovaries, it is no surprise that reductions in reproductive efficiency are seen in cows grazing infected fescue.
• There is speculation that vasoconstriction in the umbilical cord contributes to low birthweights and diminished fetal development.

On the bull side of the equation, research indicates that ergot alkaloids may:

• Affect sperm count.
• Increase the occurrence of abnormal sperm.
• Alter motility, especially during the summer months.

Fescue's effect on milk production and calving

The structural similarity of ergot alkaloids to dopamine results in reduced prolactin secretion from the anterior pituitary gland. Further, changes in gene expression in the mammary glands of cattle consuming fescue indicate alterations in their lipid metabolism and small molecule transport. Altogether, these changes translate to reduced mammary development and lower milk production. Similar changes in lipid metabolism can be seen in reduced levels of circulating cholesterol and the occurrence of fat necrosis (lipomatosis), and in some cases of long-term alkaloid exposure, these fatty masses can cause digestive issues and dystocia. 

Fescue's effect on hair coat and immune function

Reduced prolactin also leads to the rough hair coat that is often observed in cattle grazing infected fescue. Originally thought to be a retained winter hair coat, it is now known that low prolactin levels increase hair growth rates. As prolactin is a co-factor in humoral immune function, the long-term grazing of infected fescue can lead to depressed levels of immunoglobulins. However, as nutritional levels also affect immune function, more work needs to be done to determine whether altered immunocompetence is a direct result of ergot alkaloid consumption or a secondary effect of a diminished nutritional status. While there is no true fescue toxicosis treatment for cattle, there are ways to mitigate the challenges that fescue presents through management, nutrition and feed additives.

References and Additional Reading

Fribourg, H. A., D. B. Hannaway, and C. P. West (ed.) 2009. Tall Fescue for the Twenty-First Century. Agron. Monog. 53. ASA, CSSA, SSSA. Madison, WI. 540 pp. Also (http://forages.oregonstate.edu/tallfescuemonograph).

Kallenbach, R. L. (2015). BILL E. KUNKLE INTERDISCIPLINARY BEEF SYMPOSIUM: Coping with tall fescue toxicosis: Solutions and realities. Journal of Animal Science, 93(12), 5487-5495.

Mayberry, K. J. (2018). Evaluation of Genetic Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Phenotypic Variables, Calf Performance and Cytokine Response. Thesis, North Carolina State University.

Melchior, E. A., & Myer, P. R. (2018). Fescue toxicosis and its influence on the rumen microbiome: mitigation of production losses through clover isoflavones. Journal of Applied Animal Research, 46(1), 1280-1288.

Poole, R. K., & Poole, D. H. (2019). Impact of ergot alkaloids on female reproduction in domestic livestock species. Toxins, 11(6), 364.

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We all know that 2020 proved to be a roller-coaster year for commodity markets, and as we have seen over the past number of weeks, 2021 appears to be following a similar track. Grain markets rallied through the end of last year, and due to the poor availability of supplies globally, prices are continuing to skyrocket. This is happening against a backdrop of a macro-environment impacted by a weakening U.S. dollar and China ramping up its soybean imports. Considering these factors, how do we address the key challenges of mitigating risk and remaining financially and environmentally sustainable while optimizing cattle performance?

Overcoming the protein challenge

To sustain profitability, dairy and beef producers need to examine their feed management and nutritional applications. By using good-quality forage, supporting rumen health and using a tailored ration formulation, producers can cut back on their losses and keep their operations running more efficiently — thereby resulting in potential cost savings. This organizational agility is of paramount importance to overcoming the protein challenge.

Forage quality

With the continual rise of corn and soybean prices, producers should make the most of cheaper high-fiber feeds, especially forages. Plan to make the highest-quality forage possible, since this is a major component of the slowly digestible part of ruminant diets. Forage is the most variable feed ingredient in terms of its digestibility and nutrient composition, and it comprises a greater proportion of the ration than any other feedstuff. High-quality forage is more digestible, so you will be able to feed more of it. Rumen health and productivity will improve with the use of high-quality forages, and as such, forages can influence feed efficiency in dairy and beef cattle through the maintenance of a desirable rumen environment.

Support the rumen

There are several elements to increasing feed efficiency in ruminants, but one of the most important is to use the rumen to its full potential by supporting the activity and growth of rumen microflora. This enables dietary nutrients to be extracted from the diet as efficiently as possible. The nutrients provided to the rumen microflora must be well-balanced in terms of their fermentable energy and protein supply. Fermentable protein nutrition must be specifically adapted to maximize rumen microbial population activity and growth, as different populations have different requirements in term of how nitrogen is supplied.

Wasted energy means wasted profits

For years, nutritionists have overfed crude protein to meet the amino acid requirements for their desired milk yield or daily liveweight gains. Besides the significant increase in input costs, this also results in poor nitrogen efficiency and, subsequently, higher nitrogen excretion, which is detrimental to both the environment and the producer’s profits. The dairy cow inherently suffers as a result of poor nitrogen efficiency, since excessive nitrogen is converted first into ammonia and then into urea — which is partially recycled, but the vast majority is excreted. Ultimately, there is an energy loss associated with this process due to the detoxification of ammonia into urea. This energy cost comes at the expense of productivity and biological functions. The energy required to excrete excess nitrogen in a dairy cow is equivalent to up to 2 kg (4.4 lbs.) of milk and can lead to:

• Body condition loss
• Increased blood and milk urea levels
• Issues with reproductive performance

Lower protein doesn’t have to mean lower performance

With the tightening of global protein supplies, producers may face a shortage later this year and will need to stretch their existing stocks. But what if lower-protein diets could be fed while still maintaining performance? The possibility to increase nitrogen efficiency using Optigen®, a non-protein nitrogen technology from Alltech®, pushes the boundaries of protein nutrition.

Nitrogen from Optigen is more efficiently captured by rumen bacteria and is transformed into additional microbial biomass — so, why couldn’t the total dietary nitrogen supply be reduced? Researchers from Penn State University1 have looked at dairy cattle ration formulation and decreasing the crude protein supply from 16.5% to 15.5% while increasing the forage quantity fed to cows through the introduction of Optigen.

In this study, Optigen partially replaced heat-treated soybean meal and canola meal. This resulted in:

• Better nitrogen efficiency (from 28.8% to 30.8%, respectively, in the control and Optigen groups)
• Greater milk production in the Optigen group (41.6 vs. 40.5 kg/day)

This resulted in an elevated income over feed cost of $0.16/cow/day.

When it comes to beef cattle feed rations, a recent meta-analysis2 highlighted how the partial replacement of vegetable protein with Optigen exhibited a consistent improvement in the liveweight gain and feed efficiency of beef cattle. The many positive effects included an average higher liveweight gain (by 8%) and better feed efficiency (by 8%), with the inclusion of corn silage enhancing the effects of Optigen. A simulation analysis based on these benefits indicated that feeding Optigen to gain 440 lbs. in 1,000 cattle would:

• Reduce the time to slaughter by 9 days
• Reduce feed costs by $18,000
• Support a reduction in the carbon footprint of the beef unit by 111 tons of CO2 equivalents

These studies clearly demonstrate how innovations like Optigen can make improved animal performance, reduced environmental impact and financial gains not only possible but compatible.

Optigen delivers consistency when you need it most

In a world of quickly evolving change and disruption, consistency can seem idealistic. However, for a high-producing dairy cow or feedlot animal, consistency in how we feed and manage them is crucial for them to reach their optimal performance and profitability. At Alltech, we have identified “the 7 Ps of consistency” that we associate with Optigen. Over the last 15 years, these “Ps” have evolved, and several of them have been reinforced during the global pandemic — for example, the importance of securing a robust supply chain for proteins and the ability to continue supplying producers and feed companies around the world in the face of adverse conditions. There was also a question: Would Covid-19 diminish the sense of urgency around climate-friendly food production? Recent policy announcements around the world reiterated the point that food systems cannot be resilient to crises such as the current global pandemic if they are not sustainable.

With radical increases in vegetable protein costs, global attention will focus on the inherent nutrient variability between consignment and place of origin. Optigen is a solution that provides consistency when we need it most — from helping producers reduce their reliance on protein sources that fluctuate in price or that simply aren’t in supply to ensuring consistent animal performance and overall production profitability.

In summary, there are ways to lower feed costs and sustain the profitability of your dairy or beef enterprise during the current protein challenge and beyond.

Here are six tips to help you:

1. Increasing prices and demand for proteins mean that close attention should be paid to the nutritional composition of vegetable protein stocks, which could vary in their consignment and place of origin and, as a result, put animal performance at risk.
2. Make the most of cheaper high-fiber feeds, especially forages, but ensure that those forages are high-quality.
3. Support the rumen and ensure that it is being used to its full potential. This will enable nutrients to be extracted from the diet as efficiently as possible.
4. Consider feeding balanced, lower-protein diets to stretch your protein supplies, which may be necessary in case of a shortage later this year.
5. Include Optigen in your dairy and beef cattle rations as a nutritional solution for lowering your dietary protein while increasing efficiency. The partial replacement of bulky vegetable protein sources with Optigen, a concentrated nitrogen source, also creates more space in the diet to increase the inclusion of cheaper home-grown forages.
6. Take this opportunity to look at how environmentally friendly the feedstuffs you use are, as protein sources can carry a high carbon burden if they are not sourced from responsible production, ultimately impacting the long-term sustainability of the operation.

References

1. Varga et al. (2009). Effects of Optigen® on milk production, N balance and diet cost in high producing cows. Unpublished, Department of Dairy and Animal Science, The Pennsylvania State University, University Park, PA, USA.
2. Salami, S.A.; Moran, C.A.; Warren, H.E.; Taylor-Pickard, J. A Meta-Analysis of the Effects of Slow-Release Urea Supplementation on the Performance of Beef Cattle. Animals 2020, 10, 657.

I want to learn more about how I can overcome the current protein challenge and sustain profitability on my dairy or beef operation.

One of the primary goals of all livestock producers is to keep their herds healthy. Unfortunately, however, illness is often unavoidable — and some very easily transmitted but deadly ailments can be traced back to one source: Clostridium.

What is Clostridium, and how do you know when it is causing problems in your herd?

Clostridia are gram-positive, anaerobic, spore-forming bacteria that are often found in the soil and manure or in feedstuffs that have been contaminated.

“It’s around us all the time, everywhere,” said Dr. Luke Miller, a veterinary elite dairy advisor at Alltech. “Because it’s a spore former, soil contamination caused by clostridia can last through the winter. It can last in the desert, during heat stress, cold stress — all that stuff has very little effect on clostridia.”

Unlike many other disease-causing bacteria, clostridia are not contagious or passed from animal to animal.  

“There’s pretty much two ways you’re going to get a Clostridium infection,” said Luke. “You’re going to get it through either ingesting contaminated food or through a cut, an open wound or something like that. There’s always some insult that has to occur for a clostridial infection to flourish.”

It is possible for an animal to ingest clostridia and not be affected, as spores can lay dormant in the intestine. Clostridia become pathogenic when something about the animal’s diet, habitat or body changes — if the animal eats too much starch or carbohydrates, for example, or experiences a tissue injury, either internal (e.g., liver abscesses) or external (e.g., cuts or gashes). These issues — namely, a decrease in or lack of oxygen within the tissue — create favorable conditions for the proliferation of this bacteria.

Homing in on Clostridium perfringens

There are numerous types of clostridial bacteria, but cattle producers should be specifically concerned about Clostridium perfringens, which can have a major impact on an animal’s gut health — especially young animals, including calves that are less than 2 months old, because they have not yet developed a fully functioning rumen or a complete gut flora.

C. perfringens lives on starches and sugars, which explains why it proliferates when cattle start eating more carbohydrates. It can also spread when the animal experiences stress or is dealing with another condition that affects the gut, such as diarrhea. When elevated levels of the toxins released by C. perfringens enter the bloodstream — including alpha toxin, which is highly virulent — animals can experience inflammation, shock, cardiac arrest and even death.

What are the symptoms of clostridial disease in cattle?

Clostridium can lead to gut distress in cattle — especially when they are specifically dealing with C. perfringens, which can lead to symptoms and issues that include:

• Enterotoxemia (also known as purple gut; when toxins from bacteria that are usually found in the intestine enter the bloodstream)
• Severe diarrhea/stomach upset
• Abdominal pain
• Bloat
• Decreased appetite/intestinal movement
• Abomasum distention
• Leaky gut
• Bubbles in the manure
• Hemorrhagic bowel syndrome (HBS)
• Stalled calves
• ADR (“ain’t doin’ right”) — general malaise, etc.
• Blindness
• Sudden death

How can clostridial infections be prevented or defeated?

While it can be difficult to treat enteric diseases in cattle, including infections caused by C. perfringens, it is not impossible. Learn more about the various ways you can protect your animals against dangerous clostridia below.

1. Work with your vet to implement a vaccine protocol

Consult with your veterinarian about creating a proper vaccination program for your herd, as vaccines can help protect against some of the most common clostridial diseases in cattle, including enterotoxemia, blackleg, redwater and tetanus.

“There are many kinds and brands of vaccines for Clostridium,” said Miller. “Meet with your veterinarian to decide a proper vaccination protocol that addresses your operation’s needs and takes into account your regional pathogen load and issues.”

Miller also recommends being as proactive as possible about making sure your other cattle don’t contract clostridia once it has been identified in a member of the herd. After all, while clostridia can’t be transmitted from animal to animal, if the entire herd is eating the same contaminated feed or is walking on contaminated soil, more instances of infection are likely to crop up.  

2. Help the gut microbiome flourish by feeding probiotics

As defined by the National Institutes of Health (NIH), probiotics are live microorganisms that can provide health benefits by helping digest food, destroying disease-causing cells and producing vitamins. Some of the microorganisms contained in probiotics are similar to — or even the same as — microorganisms that live naturally in the bodies of humans and animals. As such, probiotics help “complement the gut biome,” in Miller’s words, making it more robust and bolstering its ability to fight off colonization by detrimental bacteria like C. perfringens.

“You can get colonization with good bacteria every day with probiotics, and they simply out-eat the competition for nutrients,” said Miller. “When they eat more starch, the Clostridium won’t be able to. They’re keeping the pH where they like it, not where the Clostridium likes it.”

3. Keep the gut healthy with products like Select BAC™

While the methods mentioned above can help protect against clostridial diseases in cattle, some intestinal issues caused by C. perfringens are not addressed by vaccines and/or probiotics. Select BAC™, a new product offering from Alltech, serves as a great nutritional solution for helping solve the problems created by Clostridium. This complete gut health pack includes both enzymes and probiotics, which play a pivotal role in maintaining the health of the gut.

“We’re throwing in the whole kitchen sink of what science thinks is good for the gut in Select BAC,” Miller said. “We’re helping you heal your herd’s gut.”

Clostridium is nearly impossible to avoid, and the effects it can have on cattle herds are difficult to grasp. Fortunately, a variety of Clostridium perfringens treatments and methods of prevention are available, including establishing a vaccination program and feeding probiotics and enzymes. Hopefully, by utilizing these techniques, producers can begin to feel more at ease about the health of their herds.

References

“Clostridial disease.” MSD Animal Health, http://www.msd-animal-health.ie/diseases/cattle/clostridial-disease/information.aspx.

“Clostridium perfringens infections in baby calves.” Drovers, 26 March 2013, www.drovers.com/article/clostridium-perfringens-infections-baby-calves.

Thomas, Heather Smith. “Calving Tips: How to Prevent Acute Gut Infection in Beef Calves.” Beef Magazine, 22 March 2013, www.beefmagazine.com/calving/calving-tips-how-prevent-acute-gut-infection-beef-calves.

Thomas, Heather Smith. “Clostridial Infections in Calves.” Angus Journal, 26 April 2017, www.angus.org/Media/News/FullArticle.aspx?asTitle=Clostridial-Infections-in-Calves&aiId=786.

I would like more information about Clostridium in cattle.

Development of more rumen-friendly rations to mitigate both environmental and physical feed waste can be achieved with Alltech IFM, a unique tool to support diet formulation

[DUNBOYNE, Ireland, and SHROPSHIRE, U.K.] – Global animal nutrition company Alltech has launched its first European-based in vitro fermentation laboratory, Alltech IFM™, in collaboration with Harper Adams University in the U.K. Alltech IFM is a nutritional tool that simulates rumen fermentation and evaluates the digestibility of feed and forages within the animal.

For farmers and feed manufacturers, the use of Alltech IFM can identify barriers to achieving optimal rumen function. It enables rations to be formulated based on nutrient availability, helping to reduce energy losses and feed wastage.

Feed samples, which can include concentrates, fresh forages, silages or total mixed rations (TMRs), are incubated using rumen fluid for 48 hours and are then analysed for volatile fatty acids (VFA) and microbial biomass. Alltech IFM measures gas production throughout the process, meaning the amount of energy lost as methane and methane emissions per animal can be calculated. Validated by the Carbon Trust, Alltech IFM is an effective tool for predicting farm- and feed-specific enteric methane emissions.

Based at Harper Adams University in the U.K., this laboratory represents Alltech’s seventh IFM facility globally.

“The introduction of our Alltech IFM lab in Europe marks a significant step forward for us as we now have the ability to analyse European-based diets and ensure our customers benefit from further technical support,” said Matthew Smith, vice president of Alltech. 

The collaboration further strengthens Alltech’s research alliance with Harper Adams University, which was formed in 2013.

“Having the Alltech IFM lab at Harper Adams allows us to undertake more fundamental studies in terms of ruminant nutrition and ruminant metabolism so that we can optimise rumen fermentation and, therefore, improve animal health, performance and longevity,” said Professor Liam Sinclair of Harper Adams University.

“The goal of looking at rumen fermentation with Alltech IFM is to minimise the waste product or minimise the gas production and to maximise VFAs and microbial biomass, which are critical nutrients to the cow,” added Dr. Jim Huntington of Harper Adams University.

“Together with the team at Harper Adams, we look forward to generating new insights and highlighting how certain diets correlate with high-producing dairy and beef systems across Europe. Now more than ever before, we believe Alltech IFM can play a significant role in helping to address those major environmental concerns, reduce waste on-farm and, ultimately, contribute to a Planet of Plenty™,” said Smith.

[DUNBOYNE, Ireland and OOSTERSINGEL, the Netherlands] – InTouch, the award-winning feed management platform, and UNIFORM-Agri, one of the world’s leading herd management software providers, are pleased to announce an exciting new data-sharing collaboration, empowering dairy farmers with cutting-edge insights and herd management tools.

Each day, InTouch manages the feeding of over 300,000 cows in 37 countries worldwide. As part of the animal health and nutrition company Alltech, InTouch puts particular focus on providing farmers and nutritionists with the most relevant insights and analytics for delivering optimum nutrition to the herd. Creating a link between InTouch and UNIFORM-Agri’s herd management platform to automatically share herd data will further enhance the value of insights that can be provided. This collaboration will also reduce the need for manual input of data and ultimately enable both farmers and nutritionists to work together to make more informed herd-management decisions.

“At InTouch, we continually strive to evolve and deliver the best service to our customers,” said Conan Condon, director of InTouch. “Collaboration is a key part of this, and we are delighted to now work with such a respected name like UNIFORM-Agri to enhance our user experience. Together, we can provide the most effective insights and ensure that the herd’s diet can be quickly adapted to any changes in milk output.”

This desire to provide the best service possible is shared by UNIFORM-Agri, which for decades has been working together with dairy farmers globally to improve management efficiency.

“With UNIFORM-Agri, we want to support dairy farmers and their suppliers worldwide with the best and most user-friendly software solutions that help to build a profitable and sustainable business,” said Harm-Jan van der Beek, managing director of UNIFORM-Agri. “Working together with a partner such as InTouch helps us to achieve the goal of making it easier for the dairy farmer to gain more insights into the herd, leading to better results.”