Strengthening its commitment to Working Together for a Planet of Plenty™, Alltech Crop Science has acquired Ideagro, based in Murcia, Spain. This partnership joins two leading platforms to accelerate soil and crop research, and to enhance biological and other microorganism-based offerings to Alltech Crop Science customers throughout the world.

“We are excited to announce that Ideagro has joined the Alltech Crop Science global team, providing us with a partner who shares our vision and significantly scaling our research capabilities,” said Andy Thomas, CEO of Alltech Crop Science. "This is the strengthening of a longstanding partnership. We have worked closely with the Ideagro team since their founding 11 years ago.”

Ideagro is a leader in agri-food research and development with a team of more than 20 scientists. It is committed to improving the productivity and profitability of agricultural systems. Its expertise in developing beneficial organisms for soil aids the growth of crops, reduces the impact of chemical inputs and helps plants to resist biotic and abiotic stress. Ideagro’s analytical capabilities, with special emphasis on in-vitro research, phytopathology, soil dynamics and microorganisms, further enable growers to identify microorganisms and quantify enzymatic activity in the soil.

“We are facing a great growth opportunity for Ideagro because we are going to have better means and more technological capacity to develop our research, which will now have a global projection,” said Pedro Palazón, CEO of Ideagro. “We will no longer only study the soils of the Iberian Peninsula, but we will work with soils from all over the world to achieve more sustainable and environmentally friendly agriculture.”

Ideagro has state-of-the-art laboratories and experimental research stations and fields for carrying out trials in Spain. To date, the company has researched more than 90 different crops and performed more than 10,000 physicochemical and biological analyses. This has led to the development of new agricultural strategies based on microorganisms.

Ideagro’s three laboratories are fully equipped with the latest technologies to focus on nutraceuticals, phytopathology, research and development and molecular biology. Its services include:

• Precise diagnoses, identification and semi-quantification of more than 290 microorganisms at the species level in different crops. Through the development of multispecific detection kits, it can simultaneously detect up to 40 pathogenic microorganisms in a single sample, with results in 24-48 hours.
• Molecular identification of microorganisms as well as genetic characterization of specific strains and determination of pathotypes of a pathogen.
• Analysis of nematodes.
• Design of specific probes for specific microorganisms. As a result, Ideagro is able to detect specific microorganisms in soil, water, plant material and biostimulants.
• Mycotoxin analyses. With more than 15,000 analyses carried out to date, Ideagro can identify and quantify the risks of aflatoxin B1, fumonisins, zearalenone and deoxynivalenol trichothecenes and T2 toxin. It provides monthly data on mycotoxin contamination in animal feed and in the main crops of the Spanish and European markets.

Ideagro is accredited by MAPAMA (EOR 82/13) and has ISO 9001:2015 certification. In June 2021, it was named a Reference Regional Laboratory by GLOSOLAN, the Global Soil Laboratory division of the FAO.

“The combination of the Ideagro expertise with the reach and scale of Alltech will allow us to extend world-leading understanding of the interface between soil, crop, animal and human health to the global market,” said Andy Thomas, CEO of Alltech Crop Science. “The potential implications of these insights cannot be understated as we endeavor to improve the vitality of our global food system, from the ground up.”

For more information about Alltech Crop Science, visit alltech.com/crop-science.

From June 2022, a zinc oxide ban, prohibiting the use of therapeutic doses of zinc oxide (ZnO) in animal feeds to control post-weaning diarrhea in piglets will come into effect in the European Union (EU). Although ZnO can still be used as a feed additive after this date, it will only be allowed at the maximum permitted dose rate of 150 ppm total dietary zinc. Before we discuss why all EU pig producers need to be ready to rear their pigs without pharmacological levels of ZnO by 2022, it is important to understand why the use of high levels of ZnO in swine nutritional diets has increased dramatically across the globe in recent years.  

Where it all began

At weaning, piglets are subject to a multitude of stress factors over a very short period that contribute to gastrointestinal tract and immune system disturbances. These factors can be:

1. Nutritional: Abrupt dietary change from sow milk to a dry, pelleted, predominantly vegetable-based diet formulation.

2. Environmental: Moving to new nursery accommodation with different housing conditions.

3. Health-based: Loss of passive immunity from the sow.

4. Physiological: Abrupt maternal separation, being handled and transported and mixing with unfamiliar pigs from other litters.

Because the pigs are under such stress, the early post-weaning period is typically characterized by poor growth performance (e.g., reduced feed intake) and increased susceptibility to post-weaning diarrhea.

Traditionally, pig producers relied heavily on antibiotic growth promoters in pre-starter and starter feeds to control pathogenic infections (mainly caused by enterotoxigenic E. coli) and improve pig growth performance in the first few weeks after weaning. This was common practice until various governmental bodies banned the use of antibiotics as growth promoters, such as the European Parliament in 2003, due to growing concerns over increasing levels of antimicrobial resistance (AMR). The continual spread of AMR has dangerous consequences for not only animal but also human health.

Following this ban, pig producers had to seek alternatives to maintain optimal gut health and to reduce this post-weaning performance drop. As a result, the use of high levels of ZnO in piglet feeds (2,000 ppm or higher) became more widespread and was seen as common practice in the swine industry. It was shown to be an effective and relatively inexpensive tool for preventing and controlling post-weaning diarrhea, with subsequent improvements in piglet growth performance, feed intake and digestion. Although the precise mode of action of ZnO against post-weaning diarrhea in weaned piglets is not yet fully understood, it is believed to be related to a significant improvement in both intestinal morphology (i.e., improved structure and function) and nutrient digestion and absorption. 

Why ban pharmacological levels of ZnO?

Though there are several benefits of using ZnO in piglet feeds (preventing post-weaning diarrhea, maintaining health and performance, etc.), recent reports have highlighted its environmental impact, and we became aware of its contribution to the spread of AMR. It is, therefore, not surprising that regulations around its use are changing and why the EU decided to ban the use of pharmacological levels of ZnO in June 2022. However, it is not all bad news for the European pig industry, as there are several potential benefits to the upcoming ban on ZnO. Some of these benefits are:  

1. Reduced environmental pollution

As previously mentioned, there are environmental concerns over the continued use of high levels of ZnO. This is primarily because zinc accumulates in soil after zinc-rich pig manure is applied to the land as an organic fertilizer. These high levels of zinc in the soil and surface water are deemed an environmental pollutant and health risk and may also impact the absorption of other trace elements, such as iron.

2. Preventing antimicrobial resistance

Recent studies and reports have demonstrated ZnO’s contribution to the increase of AMR, as high levels of ZnO may increase the proportion of multi-drug-resistant E. coli in the intestines of piglets.

3. Avoiding zinc toxicity

Zinc remains a heavy metal and is, therefore, toxic to many living organisms, including pigs. Studies show that prolonged use of pharmacological levels of ZnO may negatively affect piglet health and performance, as demonstrated by a marked decrease in feed intake. 

4. Preventing nutritional interactions

High levels of ZnO can have a negative effect on phytase activity (an enzyme that is included in piglet feeds to enhance digestion), whereby the phosphorous cannot be released from phytase due to the formation of a complex of zinc with P-phytate. When ZnO is removed from piglet feeds, it should have a positive effect on phytase efficiency.

5. Avoiding changes to gut microbial composition

The use of pharmacological doses of ZnO may also cause changes to the gut microbial composition of piglets during the early post-weaning period by suppressing the growth of beneficial bacteria, such as Lactobacilli. Such changes may negatively affect intestinal development and health in young piglets.

What is in store for pig-producing countries outside the EU?

Canada: Until recently, ZnO was typically included in piglet feeds at 2,500–5,000 ppm in Canada. However, Canada is now in the midst of imposing similar restrictions to that of the EU, which will see the level of ZnO allowed in piglet feeds reduced down to nutritional levels of 350 ppm.

China: The use of high levels of ZnO also came under scrutiny in China, and, as a result, China has drastically reduced its level of authorized dietary zinc supplementation, going from 2,250 ppm to 1,600 ppm in 2018.

United States and some Asian countries: It is very likely that the United States and some Asian countries will also implement similar restrictions on the use of pharmacological levels of ZnO in piglet diets in the near future. Although there are no restrictions currently in place in these regions, it is vital that swine producers avoid over use and start the process of working towards ZnO alternatives so that they are prepared when a ban inevitably comes into effect.

Until recently, ZnO represented one of the vital nutritional strategies for preventing and controlling diarrhea in young piglets and the associated detrimental post-weaning ‘growth check.’ However, increasing concerns over environmental pollution and contributions to the spread of AMR have led to an EU ban on the use of high levels of ZnO in piglet diets. Adopting a holistic strategy that encompasses optimal nutrition, management, biosecurity, health and welfare practices will be key to ensuring that pigs can thrive and survive in a post-ZnO era.     

Learn how the Alltech Seed, Feed, Weed solution can help you remove ZnO from your piglet diets, and start the conversation about how you can begin transitioning to ZnO-free piglet production by contacting the Alltech Gut Health Management team today.

This is part 1 of a 3-part series

*References available upon request

I want to learn more about nutrition for my pig herd.

The receiving period can be a stressful time for cattle. Recently, during the Alltech ONE Ideas Conference, Dr. Carlo Sgoifo Rossi gave a presentation titled “Receiving With Ease: Minimizing Stress During the Adaptation Phase.” Dr. Sgoifo Rossi is currently an associate professor in the department of veterinary science and technology for food safety at the State University of Milan. Utilizing his perspective and knowledge of the European beef production system, Dr. Sgoifo Rossi shared some information about the various considerations related to stress and adaptation that producers should keep in mind when implementing feeding programs and management practices.

When cattle are undergoing a transition like weaning and receiving, they experience stressors, including:

• Transportation
• Interactions with other cattle
• Interactions with humans
• Changes in nutrition

These stressors can have a major impact on cattle and can lead to such issues as changes in their immunodeficiency, reduced rumen motility, altered nutrient absorption, increased nutrient requirements and an upsurge of mineral excretion by the kidneys.

Receiving stress can lead to BRD

Regarding immune function, one common but highly concerning issue is bovine respiratory disease (BRD), which can strongly affect the performance of cattle. As illustrated in Figure 1, cattle who arrive and are treated for BRD can exhibit a decrease in average daily gains. It is also important to understand that animals who experience BRD often produce meat with lower marbling and quality grades. Considering all of these factors, mitigating BRD is important not only for the animal’s quality of life but for the producer’s bottom line and the consumer’s satisfaction.

Appropriate sanitary conditions make a difference

While the health of newly arriving animals is impacted by their location of origin, it is also greatly affected by the sanitation and management of the receiving location. According to Dr. Sgoifo Rossi, “The type of vaccination, the type of antibiotics used (and) the type of anti-parasitic product can affect the sanitary conditions of our animals.” Dr. Sgoifo Rossi encouraged producers to approach sanitation with an understanding of their specific herd and facilities and posited that, for some beef production systems, the strategy of going “all-in and all-out with cleaning and disinfection” is the best approach.

Nutrition is critical in the cattle business

When talking about management, we must be sure to properly feed and rehydrate the cattle upon arrival. Ensuring that clean drinking water is readily available and being conscious of the arrival diet are both crucial. Feeding the arrival diets in small amounts multiple times a day is recommended, as this will reduce competition among the animals, giving each of them an opportunity to receive adequate amounts of protein and energy. Arriving cattle can sometimes be considered high risk, making this a critical period for helping them recover properly and get back to normal rumen functionality.

Studies have shown that the appropriate arrival diet should have a crude protein and dry matter composition of less than 13%.

“Several studies show that if we improve the crude protein level of adaptation diets or the energy level of adaptation diets, we increase not only the incidence of morbidity but also the severity of morbidity and, consequently, the risk of mortality,” Dr. Sgoifo Rossi said.

Additionally, with the arrival diet typically being richer in forage and higher in fiber, reducing the chop length of the fiber will also reduce the likelihood that animals will sort through the ration. This is important, because sorting can cause cattle to eat too much starch or protein, which can lead to fluctuations in the pH level.

Consider all of the nutritional needs of arriving cattle

Unsurprisingly, it is also important to consider the nutrients available in the arrival diet. Providing new-arrival animals with the proper nutrients will improve their immunity, digestibility, and energy and protein balances.

To recover rumen and immune system functionality in newly arrived cattle, it is important to consider diets that include the following:

• High levels of digestible fiber
• Yeast
• Mannan oligosaccharides (MOS)
• Slow-release nitrogen
• Vitamins
• Minerals

As mentioned previously, the arrival period is so critical for getting cattle right. Vitamins, minerals and other supplements can help improve their feed and can be fundamental in helping these cattle adapt to their new home. In his presentation, Dr. Sgoifo Rossi mentioned that studies have shown that organic zinc and selenium, live yeast and mannan oligosaccharides can be huge players in the reduction of morbidity and mortality in these potentially high-risk cattle.

Too often, producers and nutritionists underestimate the importance of these ingredients, leading to negative results. Dr. Sgoifo Rossi shared a study completed in Italy that examined the mineral status and mineral plasma levels of cattle after arrival. This trial focused on the evaluation of various mineral levels in the blood immediately after arrival. As shown in Figure 2, 83% of new-arrival beef cattle were in a deficient or sub-deficient condition regarding their copper availability, and 30% displayed deficient or sub-deficient zinc availability and reserves.

Weather can be a stressor

Weather can play a significant role in cattle stress, and more thoughtful management practices should be implemented with the weather in mind. Spring, summer and fall are less of a concern when it comes to sanitation management, but winter is a critical period for sanitation. Producers often forget to consider the relationship between temperature and humidity during the winter and how it can lead to cold stress. This can create a potentially dangerous environment for cattle and can result in increased incidences and more severe cases of BVD. As shown in Figure 3, low-temperature, high-humidity environments can create a risk area where sanitation conditions are an issue, leading to a slower adaptation for arriving animals.

As previously mentioned, there are challenges leading up to and during the receiving period that can result in the highest risks of morbidity and mortality. Implementing the proper sanitation and vaccination protocols, providing sick animals with antibiotics, being proactive about their nutrition, and understanding which management practices to use based on the origin of your cattle, as well as their transportation details and the time of year, are all effective ways to mitigate any potential challenges associated with receiving cattle.

I want to learn more about nutrition for my beef cattle.

Feed is expensive — especially the grains that serve as the major energy source in most finishing rations for beef cattle. With this expense on the rise, nutritionists work hard to make sure that their feedlot rations for beef cattle are high-quality feeds that support weight gain and feed conversion efficiency. 

Energy is a key element to consider when developing a feed to promote weight gain in beef cattle. Both grains and forages contain energy that is useful when finishing beef cattle. Grains are considered high-energy feeds because the energy in grains comes largely from starch. Starch is composed of glucose chains, which can easily be broken down by rumen microorganisms. The structural components of forage — such as cellulose, hemicellulose and lignin — surround the nutrients with complex linkages. Rumen microbes can’t always break these linkages, however, limiting the availability of energy in the forage. This is particularly true for feedlot cattle, as the ruminal pH of feedlot cattle is less than optimal for fibrolytic microorganisms, resulting in reduced fiber digestion.

When thinking of these structural components, imagine them as locks protecting the energy and nutrients in feedstuffs. Enzymes — which are either endogenous, from the microbial population, or the exogenous enzymes in feed additives — can break apart these protective structural components, unlocking both the potential of feeds and the potential of the cattle being fed.

Enzymes can make a difference in finishing cattle

The scientific literature shows inconsistent results for enzyme use in beef cattle diets. However, this is likely due to the wide variety of enzymes that have been tested, the vast array of feedstuffs that have been used in experimental diets, and the kind of data that has been recorded. For example, cattle grazing cool-season versus tropical grasses have different enzymatic needs, because those grasses have different chemical compositions. The same goes for cattle consuming corn silage versus barley-based finishing diets. This is especially true in diets that utilize byproducts, as the most easily accessible nutrients have generally already been extracted by the initial industry that processed the material.

• Starch-based diets: Corn, barley
• Forage-based diets: Corn silage, barley silage, hay and grasses
• Byproducts in diets: Corn gluten meal, distillers grains, cottonseed hulls, etc.

The rumen is a complex, enzyme-rich environment. The microbes of the rumen can break down most components of foods — but the extent and speed of this breakdown is often a limiting factor for nutrient release. A common question when discussing rumen efficiency is: Can a small enzyme addition really make a change in rumen function and feed digestion?

For an enzyme to be effective, several factors need to be met:

• It must fill a gap in feed digestion not met by the existing microbiota.
• The type of linkage it opens must be present in the feed.
• The enzyme needs to be stable in stored and mixed feed.
• The enzyme must be active at rumen temperature and pH.
• It must be able to survive in the feed.

Returning to the lock-and-key metaphor about enzymes, any enzyme added to a diet must fit the “locks” on the components of that diet.

How do you measure enzyme efficacy in finishing cattle?

Measuring the effects and value of enzymes can be tricky. Often, researchers expect an increase in the rate or extent of digestion for a particular diet component — and sometimes, they are right. Other times, however, the enzyme acts in an unanticipated way, such as changing the rate of passage to promote feed intake, shifting the metabolites available to microbes in the rumen, or even affecting downstream metabolic processes. If researchers are not measuring these actions, they may conclude that the enzyme had no effect, when in reality, they were simply looking in the wrong direction and missed the action of the enzyme. As such, in enzyme research, it is important to look beyond intake, weight gain and feed conversion and to measure a wide range of parameters to fully capture the effects and mechanisms of a given enzyme. 

Outside of the scientific realm, it’s important to recognize what you expect an enzyme to do when it is added to the diet. Here are a few common reasons for utilizing enzymes:

• By incorporating enzymes into your finishing rations for beef cattle, you may be able to utilize lower-cost ingredients in the diet while still experiencing equal performance.
• Enzymes can help improve feed efficiency in feedlot cattle without making any other changes to the diet.
• Getting more pounds on your animals can be possible with enzymes. Certain enzymes can support superior carcass weight. More pounds per day = more dollars.
• Some enzymes reduce digesta viscosity, which can contribute to better post-ruminal nutrient absorption and support digestive health. Get the most out of your rations.

Look at your cattle’s diet and your goals for your operation. Could enzymes help you reach those goals?

There are enzyme options available — just know your goals

Most research on cattle focuses on tweaking existing procedures, feeding plans, etc. Researching enzymes takes years of trial and error, on both the benchtop and in the animal, to find effective, cost-efficient, scalable options. This type of research is slow but generates the knowledge that can lead to new insights and technologies that allow us to maximize feed efficiency in feedlot cattle. New enzymes are popping up regularly. If you choose to utilize these additives in your feedlot rations, be sure that they are effective on the ration ingredients you use and will provide the results you want in your operation. Consult with your nutritionist or an Alltech representative below to learn more about how enzymes can work in your operation.

I want to learn more about nutrition for my beef cattle.

While your average person is still snuggled underneath their blankets in the early morning, Corne VanDenAkker can be found in his barn, tending to the task of milking his herd of cows. There, he reflects on his relationship with farming, which is rooted in a tradition going back almost forty years, beginning when his family made the move from their homeland in Holland to their current homestead in Canada. Upon making the choice to continue this farming tradition, VanDenAkker began farming full-time on his own land and tending his herd after earning a degree from the University of Guelph. Since then, he has grown his herd to over 100 head, added milking robots to modernize his operation, and is continuously seeking how to become a better, more efficient and sustainable farmer.

Through his years of experience, VanDenAkker knows the importance of being cognizant of what goes into his dairy cows in terms of what they eat and the balance of nutrients required to maintain his herd health and optimal milk production. However, he was unsure if he would be able to support his herd with the yields from his own fields. 

Everything we grow goes into our cows

“Everything we grow goes into our cows,” VanDenAkker noted when discussing the 250 acres of corn that is farmed and destined for his own silage. “I didn’t know if I could feed them enough to support the milk.”

VanDenAkker has long used Alltech products such as Yea-Sacc and Optigen in his livestock feed, and five years ago, he was introduced to Grain-Set, an Alltech Crop Science product geared toward grain crops. He began applying it on 40 of his silage corn acres, and over the years since, he has seen consistent results at every harvest. 

“Year after year, we are seeing improved cob fill and an increase in the number of bushels we are getting from those fields when compared to the untreated area,” VanDerAkken said, adding that his average increase is more than 10 bushels per acre.

This crop yield increase is formidable, but the data that really impressed VanDenAkker came after he began feeding his Grain-Set-treated corn silage to his cows. 

“They increased their milk production when we switched,” he said. “I saw a trend in the increase but couldn’t be sure (that it was totally related to Grain-Set).” 

Backed by Science

VanDenAkker’s curiosity about the results prompted him to dig deeper into what he was seeing, and he decided to send samples of both his treated and untreated corn silage for analytical testing. The results spoke for themselves: The Alltech Crop Science-treated corn silage showed a 5.8% increase in neutral detergent fiber (NDF) digestibility. This meant that the dairy cows were getting more energy and taking in more nutrients from the feed, allowing them to not only increase their milk production but to also have more balanced rumen health. These improvements help increase farmers’ profitability and make their systems more efficient.       

What is the science behind these results? Simply put: nutrigenomics. Gene expression helps corn silage crops better withstand environmentally stressful conditions, like drought or overly wet soils, and both biotic and abiotic stress. The plants respond by inducing their own resistance to these stressors and improving their own performance.  

Based on these results, VanDenAkker is enthusiastic about his plans to continue using Grain-Set on his silage corn. When asked about the difference he has seen in his cows, VanDenAkker smiled pragmatically and said, “I feed the cows myself, and I can see the results for myself. They are eating better and getting what they need from the feed. I always had good cows, but they are very decent now.”

What is Grain-Set?

Grain-Set is a unique blend of micronutrients and fermentation products and is specifically formulated for cereal, grain, forage and oil crop production.

• Provides nutrients essential for plant metabolic processes
• Increases grain weight and yield
• Optimizes crop uniformity
• Improves grain fill and quality
• OMRI-listed for use in organic production

Have a question? Contact us!

Aquaculture, in contrast with capture fisheries, has remained stable over the last few decades. The industry continues to grow and contribute to the increasing food supply for human consumption, reaching worldwide production of 80 million metric tons (Mt) in 2016. To sustain its growth, the aquaculture industry is highly dependent on commercial feed sources. The inclusion rate of traditionally used finite and expensive marine protein and fat sources from wild-caught fish (i.e., fishmeal and fish oil) in the diets of farm-raised fish species will continue to decline, and the industry has already shifted to crop-based raw materials to meet the rising demand for aquafeeds.

Fish require several carefully chosen raw materials to provide them with a healthy diet, but fish-based proteins are not essential. The industry has recognized this, and there are now many fish feeds with 0% fish-based protein ingredients and an industry average (FIFO Factor). Plant-based feed ingredients increasingly replace marine-based components, and therefore, an enhanced level of understanding of the nutritional quality of raw materials derived from plant sources is becoming increasingly crucial for aquafeeds. Moreover, the higher inclusion of less-expensive plant sources may introduce a series of anti-nutritional factors (e.g., protease inhibitors, phytates, saponins, glucosinolates, tannins, non-starch polysaccharides) and/or increase the occurrence of mycotoxins in fish feed; factors that may affect the quality and safety of aquafeeds.

Mycotoxins in aquaculture feed

Mycotoxins are fungi that can grow on crops during growth, harvest, processing or storage. The development of these fungi is climate-dependent and most commonly seen in tropical regions. In these climates, the fungi produce chemical compounds known as mycotoxins and can have a greater impact on animal health.

Fish farming is a diverse industry, and each aquaculture species will have different sensitivities to the impacts of mycotoxins. These can cause a reduction in performance — reduced growth and increased feed conversion ratio (FCR) — and increased disease susceptibility and mortality rates. As these issues can be attributed to other concerns, the risk can often be overlooked and underestimated in aquaculture.

Mycotoxins are mainly detected in plant-based feedstuffs, readily present in corn, wheat and soybean meal. Increasingly, the occurrence of mycotoxins has been reported in aquafeeds. There are over 50 different types of mycotoxins, but the most commonly known and most prevalent is deoxynivalenol (DON).

Effects of deoxynivalenol on the health and growth of farmed fish species

Accumulation of DON in fish can be harmful and impact their performance. In terms of occurrence and toxicity, DON has been characterized as the most high-risk mycotoxin in aquafeeds. Its effects include:

1. Ribotoxic stress response: DON binds to ribosomes, inducing a “ribotoxic stress response” that activates mitogen-activated protein kinases (MAPKs).

2. Oxidative stress: DON causes oxidative stress in cells by damaging mitochondria function, either through the excessive release of free radicals — including reactive oxygen species (ROS), which induce lipid peroxidation — or by decreasing the activity of antioxidant enzymes.

3. Impacting epithelial cells in the digestive tract: Predominantly, rapidly proliferating cells with a high protein turnover, such as immune cells, hepatocytes and epithelial cells of the digestive tract, are affected by DON.

4. Reduced growth rate: In Atlantic salmon diets, 3.7 mg/kg of DON resulted in a 20% reduction in feed intake, an 18% increase in FCR and a 31% reduction in specific growth rate. In white shrimp, DON levels of 0.5 and 1.0 ppm in the diet significantly reduced body weight and growth rate, while FCR and survival were not affected.

5. Decreased immune system response: Mycotoxins impair optimum animal performance by affecting intestinal, organ and immune systems. These, in turn, negatively impact overall performance and profitability.

6. Reduced feed intake: A study conducted by Woodward et al. (1983) showed that rainbow trout had a sharp taste acuity for DON. Their feed intake declined as the concentration of DON increased from 1–13 ppm of the diet, resulting in reduced growth and feed efficiency

The impacts will vary on many factors, including the quantity, feeding level, duration of exposure and aquatic species. A recent meta-analysis completed by Koletsi et al. (2021) highlights the risk of DON on feed intake and growth performance. In parallel, data was collected to quantify the risk of exposure in fish. The extent to which DON affects feed intake and growth performance was evaluated by employing a meta-analytical approach.

Having completed a full meta-analysis of the current research and trial data available for the aquaculture species, Koletsi et al. concluded that the current recommendation for the limit of DON in fish diets is too high and needs to be reviewed in order to protect the welfare of fish and maintain an economic advantage.

Preventing mycotoxins in aquaculture

Maintaining a good management system will help to control the mycotoxin risk. However, some mycotoxins remain stable, even after high-temperature extrusion processing. For this reason, additional steps should be taken to mitigate the risk. Alltech mycotoxin management tools, such as Alltech 37+® and Alltech® RAPIREAD, help farmers and feed producers identify their total mycotoxin risk (REQ). Evaluating risks associated with mycotoxins on animal performance and financial losses can be more rapid than ever before. Additionally, to further manage mycotoxin risk and understand what you can do for your business, you can visit knowmycotoxins.com.

References available on request.

I want to learn more about aquaculture nutrition.

At this point, most of us know that the gut microbiome is an important component of overall health. With estimates asserting that mammals contain around 10 times more bacteria than cells in their bodies — and 1,000 more microbial genes — the importance of a healthy gut cannot be overstated.

While many of us have heard about prebiotics and probiotics for dogs and cats, the new term on the block is “synbiotics,” which are simply an effective and beneficial combination of pro- and prebiotics for cats and dogs. Current research shows that the right combination product could be a game changer in pet food diets.

How do prebiotics and probiotics for dogs and cats work together?

Here’s a quick refresher:

• Probiotics are consumable live microorganisms that have beneficial effects when fed in the appropriate concentrations.
• Prebiotics are fiber or fermented ingredients that pass through the GI tract undigested and positively influence the microbes in the gut.

In simple terms, probiotics are good bacteria, and prebiotics help feed those good gut bugs.

Synbiotics were created as specific combinations of pro- and prebiotics that work well together. Basically, synbiotics are selective strains of bacteria with specific prebiotics that best support those microbes.

Once in the body, synbiotics can act in various ways to support health.

What do prebiotics do in the body?

Upon being ingested, prebiotics pass through the animal’s stomach and small intestine without being broken down by hydrochloric acid or digestive enzymes. Once they reach the large intestine, prebiotics get to work as the “fuel” for the good bacteria in the gut.

Prebiotics work together with probiotics to maintain a delicate balance and diversity of organisms in the GI tract. As probiotics are fueled, the body reaps more benefits.

Additionally, as prebiotics are fermented and used by probiotics, short-chain fatty acids — such as butyrate and other postbiotics — are generated. These postbiotics are used by the cells of the GI tract as a nutrient source, which further contributes to a healthy gastrointestinal tract.

What do probiotics do in the body?

Different probiotic strains have different mechanisms of action in pets. Some examples of how probiotics can influence health include:

• Competing with and displacing bad bacteria in the GI tract by attaching to the intestinal lining
• Producing antimicrobial substances like fatty acids
• Inactivating toxins
• Up-regulating the production of beneficial metabolites
• Enhancing immune system function
• Supporting the integrity of intestinal epithelial cells

While many strains of probiotics are used in dogs and cats, some of the more common and widely researched include Enterococcus faecium, Lactobacillus acidophilus and Bifidobacterium spp. animalis.

Multiple studies have shown that the gut bacteria composition of dogs experiencing digestive diseases, such as chronic diarrhea and inflammatory bowel disease, is altered compared to the gut bacteria of healthy dogs, which suggests that probiotics for dogs with diarrhea and other dysbiosis-inducing conditions may be one solution for better health.

What benefits do synbiotics provide?

As stated above, the whole point of synbiotics is to create one combination product that provides a net benefit for the animal based on synergistic pre- and probiotics.

Research trials involving pre- and probiotics for cats and dogs that study the most effective mixture of strains are limited, and the results of the trials that have been conducted vary greatly due to the myriad ways to test changes in the gut microbiome, as well as the different concentrations of beneficial bacteria and fiber being offered and the timing of administration with respect to other foodstuffs or medications. That being said, let’s look at what we do know.

One study in healthy, trained sled dogs found that a synbiotic that included E. faecium, Bacillus coagulans, L. acidophilus, and multiple prebiotics and vitamins led to an increase in Lactobacillaceae bacteria and the concentration of butyrate, as well as a decrease in diarrhea. In cats with chronic diarrhea, administration of a proprietary synbiotic blend improved fecal scores significantly after only 21 days.

Several studies have investigated the use of synbiotics in cats in conjunction with clindamycin, an antibiotic known to induce significant GI changes and distress in both pets and humans. In one trial, the use of a synbiotic with clindamycin in previously healthy cats illustrated synbiotics’ potential ability to mitigate some loss of beneficial bacteria. Additionally, the cats receiving the synbiotic also seemed to have altered levels of polyamine synthesis. Polyamines aid in the repair of the intestinal lining and have anti-inflammatory properties, so this is particularly interesting and will require more research to fully understand.

While the science continues to evolve, what we already know for sure is that supporting the microbiome and continually improving the gut ingredients available for pets will be hugely important in differentiating pet food brands.

How to market synbiotics

Adding a winning combination of probiotics and prebiotics to pet food diets is not only advantageous for good gut health and an optimal pet immune system but could also be profitable for businesses.

With pet parents always looking for an “edge” for their pets, adding a custom combination product that fits your brand’s needs is crucial for brand awareness and recognition. In a crowded marketplace, the smallest ingredients in the bag are often the biggest market differentiators.

Additionally, in the human nutrition marketplace, the idea of synbiotics is becoming more and more mainstream, which means that people will soon be looking for this word on pet food packaging.

When marketing synbiotics to consumers, here a few tips:

1. Identify the main reason why your company chose these particular strains of bacteria and supportive fiber.
2. Boil your main “why” into less than 10 words for each strain or fiber source.
3. Educate consumers so that they understand why your brand has selected these particular ingredients and why what you are offering is different from other brands.
4. Communicate obsessively via your channels. If it feels like you are repeating the same language, then you are doing it right! Most people need to hear something at least seven times before it really solidifies as fact in their brains.

As a company founded on science, Alltech’s technologies continue to be researched as extensively as they have for the past 40 years. We can help identify the custom blend of ingredients that would best serve your pet food brand based on your unique needs, processing techniques and marketing strategies.

In the end, our mission is healthy pets and healthy partnerships.  

To find out more about Alltech’s pet solutions, fill out the form below.

People interpret sustainability in different ways. Hence the uncertainty and divisiveness the topic can create in discussions. In contrast with other industries, the agri-food sector has the unique position of being a solution provider when it comes to mitigating emissions and supporting biodiversity in our local environments. Animal feed is integral to profitable and efficient dairy and beef farming. Therefore, feed production has a crucial role in how we lower the environmental impact associated with the food system.

Strengthening the links in our chain

COVID-19 has emphasized the need for such resilient food systems. Feed production capacity is directly correlated to the amount of food available for human consumption and, indeed, general food security. Alltech’s experience across 128 countries finds that sustainable and efficient feed supply chains are relevant to small-scale livestock production all the way up to some of the world’s largest integrators. A growing challenge for the feed industry is competition with humans for similar feed sources. This challenges the feed additive inclusion to improve rumen efficiency and exploration of bespoke feed ingredients that only ruminants can utilize. Sustainable animal feeding has and is being practiced. Through Alltech’s unique network of eight Alltech IFM™ (in vitro fermentation model) labs around the world, we can verify in greater detail diet efficiency and where scope exists to lower emissions and improve producer profitability. 

Can you verify that?

It is no longer sufficient to simply claim a low carbon footprint for your livestock production system or animal feed. This needs to be supported by repeatable, measurable and verifiable evidence. Alltech E-CO₂ has developed the Feeds EA™ model to help feed manufacturers and producers globally measure and lower the carbon footprint of their feed. Feeds EA measures the environmental impact of feed production at the feed mill level by assessing the effects of existing compounds or blends. This is determined by calculating greenhouse gas emissions from production, cultivation, processing, energy utilization and transportation in feed manufacturing. Feeds EA™ can calculate emissions from a database of more than 300 ingredients, including raw materials, soya products, byproducts and additives.  

In reducing food waste through circular agriculture-type initiatives, we can be confident about the resilience of our food production systems to embrace more efficient resource utilization. This is exemplified in initiatives such as supplementation of byproducts to ruminants and closing nutrient loops. By lowering food loss and waste in our livestock production systems in a verifiable way, we can continue to make a strong case for the sustainable solutions our industry offers in slowing the pace of climate change.

Mitigating waste

Precision agriculture and the application to animal nutrition has been proven in recent Alltech meta-analyses on dairy (Salami et al., 2021) and beef research (Salami et al., 2020) to lower environmental impact through improved nitrogen utilization in ruminant systems. Optigen® supplementation through dairy diets was shown to:

• Improve nitrogen utilization efficiency in dairy cattle by 4%, thanks to better nitrogen capture in the rumen.
• Reduce manure nitrogen excretion by 12–13 g of nitrogen/cow/day.

This data suggests, for example, that the use of Optigen could reduce the annual manure nitrogen excretion from the U.S. dairy sector by an average of 51,509 metric tons of nitrogen based on the annual milk output.

Simply put, this approach is trying to provide ‘the right amount of nitrogen, at the right time, in the right place’ to help in reducing waste on farms. Results from the meta-analysis also showed that the use of Optigen in dairy diets resulted in a carbon saving of around 54 g of CO₂e per kg of milk. When extrapolated to the annual milk output of the German dairy sector, for example, this would be equivalent to a carbon emission reduction of 1.8 million metric tons of CO₂e. Such a carbon saving represents 16% of the entire reduction target for German agriculture by 2030.

A simulation analysis based on the results of the meta-analysis indicated that feeding Optigen to 1,000 dairy cows would:

• Increase income over feed costs by $18,000.
• Reduce the carbon footprint of the herd by 647 metric tons of CO2e. That carbon reduction is the same as taking 424 cars off the road or 436 houses’ use of electricity.

The meta-analysis on beef research highlighted how the partial replacement of vegetable protein with Optigen exhibited a consistent improvement in the liveweight gain and feed efficiency of beef cattle. The many positive effects included an average higher liveweight gain (by 8%) and better feed efficiency (by 8%), with the inclusion of corn silage enhancing the effects of Optigen.

A simulation analysis based on these benefits indicated that feeding Optigen to gain 440 lbs. in 1,000 cattle would:

• Reduce the time to slaughter by 9 days.
• Reduce feed costs by $18,000.
• Support a reduction in the carbon footprint of the beef unit by 111 tons of CO₂e. That carbon saving is the same as taking 73 cars off the road or 75 houses’ use of electricity.

Sustainability does not have to come at a cost

Lowering the environmental impact from animal feed does not imply lowering revenues for food system stakeholders. From large dairy farms in the U.S. to the 300 million dairy cows predominantly spread across small farms in India, Alltech has firsthand experience of how sustainable solutions have become the non-negotiable in animal nutrition. Profitable farming understandably leads this agenda. With animal feed typically representing the most significant variable cost in producing animal products, there is a business responsibility to ensure we minimize food loss and waste.

Animal feed production has humbly underpinned the food system that has enabled global population growth over the last 150 years. It is now time to recognize this unique contribution and how it also serves in discovering and implementing technologies that lower the environmental impact of animal products and support the circular economy.

Considering sustainability efforts need to make both environmental and economic sense, don’t miss our related blog 6 tips to stretch protein supplies and lower your feed costs.

I want to learn more about ruminant production.

If your pet food company produces balanced diets for puppies and kittens, you know that it is not always easy to differentiate yourselves from the competition.

With numerous options at the neighborhood pet food store and on the increasingly popular e-commerce sites, new pet parents are often bombarded with decisions. Should they go with raw diets for puppies? Dry or wet food for kittens? High-protein diets? Vitamin and mineral supplements?

Ultimately, you want pet consumers to choose your nutrition programs. Let’s look at three ways to make sure that your puppy and kitten diets stand out on the shelf.

1. Beware of the “high-protein” hype.

Yes, puppies and kittens have nutritional requirements that include high protein and calorie levels, but be wary of oversimplifying this message.

Protein sources are not created equal, and claiming that a food is “high protein” is not as important as the levels of essential amino acids that are present in the diets of young kittens and puppies.

Protein requirements for puppies and kittens are really requirements for higher levels of high-quality protein. Do your best to convey to consumers that your pet food brand contains excellent-quality protein from a traceable source that specifically meets the needs of a puppy or kitten.

Furthermore, taking a step backwards, a growing animal’s body also requires nutrients that support its cells’ ability to produce proteins.

Nutrients such as nucleotides, which are the molecules that make up an animal’s genetic material (DNA and RNA), are in high demand throughout the animal’s life, but never more so than during the growth phase, when the gastrointestinal and immune systems are developing quickly.

Nucleotides are found in high levels in the mother’s milk, but young companion animals still have an increased need for nucleotides, even after weaning. Research has shown that nucleotide supplementation in puppies increases their immune systems’ capacity to respond to dangerous diseases, such as parvovirus.

Arming your pet food with the organic molecules and amino acids that really matter for growth and development in puppies and kittens, such as those found in Alltech’s NUCLEO-SACC™, will deliver real results for your consumers and, ultimately, the pets they love.

2. Make it palatable.

This may seem fairly obvious, but reduced food consumption in growing kittens and puppies can lead to major growth and developmental problems.

It is important to communicate to pet owners that while the desired growth rate for both puppies and kittens is “slow and steady” so as to prevent the over-development of their musculoskeletal systems, young animals will grow the quickest in their first 6 months of life and need to be fed in line with those needs.

Building your puppy and kitten diets with highly palatable ingredients, such as glutamic acid, can help promote feed intake in a controlled manner. Additionally, using a body condition scoring system can help to guide nutrition for kittens and puppies. Teaching pet owners how to use body conditioning can help prevent under- or over-development.

For both dogs and cats, body condition is typically assessed on a scale of 1 to 9, with 1 being severely underweight and 9 being obese. An ideal body condition for cats and dogs is between 4 and 5, where their ribs can be easily felt but not seen and a waistline can clearly be identified.

In growing companion animals, body condition is likely to change more rapidly, and there could very well be some “awkward” growing phases. All is well. The important thing is to keep their body condition in mind so that you can adjust their diet as needed before anything gets too out of whack.

Overall, helping consumers understand that growing pets require a balanced diet that meets their increased nutritional demands without overloading their body systems is key. Designing pet food diets that are palatable and therefore encourage consumption means that consumers are less likely to overfeed an imbalanced ration to compensate for what is missing, and that could have a hugely positive downstream effect on their pets’ long-term health.  

3. Focus on functional nutrients.

Functional nutrients are those that may provide health benefits beyond the basic nutritional requirements. Regardless of what type of pet food your company produces, be sure to include functional nutrients that can assist with young companion animals’ proper growth and development.

One functional nutrient that often goes unmentioned is inositol. Inositol is a sugar that is found naturally in the body. Inositol supports proper nerve and muscle function, in addition to optimal cell membrane development. Because of its role in cell structure, it is important for growing animals to have quality sources of inositol in their diets.

Additionally, ensuring that your young companion animal pet food contains 100% organic trace minerals (including copper, zinc, manganese, iron and selenium) will provide a huge boost to your nutrition program. Trace minerals are especially critical during growth to ensure the proper development of all of the animal’s body tissues. Organic trace minerals have been shown to be absorbed and utilized at higher rates in the body than their inorganic counterparts, which means that development and performance can be improved just by feeding your brand’s diet!

Summary

Ultimately, you care about your pet food diets because you care about the puppies and kittens who will be eating them.

Adding sufficient levels of functional nutrients — such as essential amino acids, nucleotides, inositol and glutamic acid — in addition to high-quality essential trace minerals will make your pet food brand the best it can be while also ensuring incredible results for your customers’ new family members.

I want to learn more about pet nutrition.

The pathology of cattle consuming endophyte-infected tall fescue varies greatly based on the weather and the alkaloid concentration. The most readily apparent signs of fescue toxicosis include reduced feed intake, weight gain, milk production and reproductive efficiency, as well as tissue necrosis and a rough hair coat. Decreases in productivity caused by fescue toxicosis are estimated to cost U.S. beef producers more than $2 billion annually (Kallenbach, 2015).

Absorption of alkaloids

Calculating the animal’s retention of ergot alkaloids is difficult due to biotransformation. Generally, it is estimated that 76–92% of consumed ergot alkaloids are absorbed, with the other 8–24% excreted in the feces. The math on alkaloid absorption and excretion doesn’t always add up, as alkaloids are broken down and/or biotransformed into numerous metabolites. Most alkaloids are ultimately excreted in the urine as lysergic acid.

Fescue alkaloids and microbiome shifts

An emerging area of research is the interaction between fescue alkaloids and the microbiome. Decreases in the Erysipelotrichaceae family and increases of Ruminococcaceae, Lachnospiraceae and Clostridiaceae, as well as abundances of Planctomycetes, Chloroflexi and Proteobacteria phyla have been reported for cattle grazing infected fescue. Fescue seed extract, when added to in vitro fermentations, led to increased populations of tryptophan-utilizing bacteria. Considering the tryptophan base of ergot alkaloids, this increase likely indicates an up-regulation in detoxification capacity. The characterization and identification of the three isolates with the highest conversion abilities found that all three were gram-positive, spore-forming rods that produced ammonia from tryptophan, classified as Clostridium sporogenes.

Receptor-binding of fescue ergot alkaloids

Due to the structural similarity of ergot alkaloids and serotonin, dopamine, norepinephrine and epinephrine, several receptor types in numerous tissues are affected during fescue toxicosis in cattle. This results in a wide range of effects on physiology and metabolism. As more research examining the underlying mechanisms is completed, the connections between ergot alkaloid receptor-binding and animal performance grow more complex.

Individual animal sensitivity to infected fescue is affected by:

• Environmental conditions.
• The density of the receptors.
• The capacity for liver and ruminal degradation.
• Other genetic factors.

Fescue's effect on weight gains

Ergot alkaloid-induced vasoconstriction reduces heat dissipation, resulting in a variety of physiological fescue toxicosis symptoms in cattle, including an increased respiration rate and elevated core body temperature. Ultimately, this leads to lower weight gains — which is generally known as the summer slump, as animals spend less time grazing as a result of standing in the shade or water to cool off. In colder months, fescue-associated vasoconstriction combines with thermoregulatory vasoconstriction, resulting in tissue death in the extremities, which is commonly known as fescue foot.

Ergot alkaloid consumption also leads to:

• The thickening of the medial layer of blood vessels
• Endothelial cell damage
• Vascular stasis
• Thrombosis
• Ischemia
• Changes in blood pressure, among other cardiovascular effects

Fescue's effect on rumen fill

The frequency and amplitude of the ruminal contractions, as well as changes in eating patterns due to fescue toxicosis in cattle, combine to affect rumen fill, passage rates and intake.

• Vasoconstriction also reduces blood flow to the rumen, decreasing VFA absorption.
• Increased rumen fill provides a negative feedback loop, exacerbating reduced intakes.
• While the total tract digestibility of the feeds is generally unchanged, these alterations work in concert to reduce nutrient availability, contributing to the reduced growth rate frequently observed in cattle grazing fescue.
• Added to this are the effects of alkaloids on circulating serotonin levels, the hypothalamic center and tryptophan-related satiety.

Fescue's effect on energy metabolism

Ergot alkaloids affect energy metabolism primarily when alkaloid intakes are high and during heat stress. Growth differences in cattle during fescue toxicosis are most likely the result of reduced intake, as no differences in retained energy or energy partitioning were caused by alkaloid ingestion when feed intake was equal.

• When fed near maintenance, cattle had lower basal metabolic rates.
• At higher feeding rates, maintenance energy requirements increased.
• When combined with observed increases in fat loss and a higher capacity for gluconeogenesis in the liver, this indicates the prioritization of energy (when available) toward elevated respiration, thermoregulation and alkaloid detoxification.

Economic losses due to fescue toxicosis

As much as 75% of the economic losses attributed to infected tall fescue pastures are related to decreased calving rates.

For cows:

• Alkaloid consumption reduces the circulating levels of several hormones important for reproductive efficiency, including progesterone and estradiol.
• Changes in ovarian follicle development, oocyte quality and luteal function have been reported.
• When combined with vasoconstriction to the uterus and ovaries, it is no surprise that reductions in reproductive efficiency are seen in cows grazing infected fescue.
• There is speculation that vasoconstriction in the umbilical cord contributes to low birthweights and diminished fetal development.

On the bull side of the equation, research indicates that ergot alkaloids may:

• Affect sperm count.
• Increase the occurrence of abnormal sperm.
• Alter motility, especially during the summer months.

Fescue's effect on milk production and calving

The structural similarity of ergot alkaloids to dopamine results in reduced prolactin secretion from the anterior pituitary gland. Further, changes in gene expression in the mammary glands of cattle consuming fescue indicate alterations in their lipid metabolism and small molecule transport. Altogether, these changes translate to reduced mammary development and lower milk production. Similar changes in lipid metabolism can be seen in reduced levels of circulating cholesterol and the occurrence of fat necrosis (lipomatosis), and in some cases of long-term alkaloid exposure, these fatty masses can cause digestive issues and dystocia. 

Fescue's effect on hair coat and immune function

Reduced prolactin also leads to the rough hair coat that is often observed in cattle grazing infected fescue. Originally thought to be a retained winter hair coat, it is now known that low prolactin levels increase hair growth rates. As prolactin is a co-factor in humoral immune function, the long-term grazing of infected fescue can lead to depressed levels of immunoglobulins. However, as nutritional levels also affect immune function, more work needs to be done to determine whether altered immunocompetence is a direct result of ergot alkaloid consumption or a secondary effect of a diminished nutritional status. While there is no true fescue toxicosis treatment for cattle, there are ways to mitigate the challenges that fescue presents through management, nutrition and feed additives.

References and Additional Reading

Fribourg, H. A., D. B. Hannaway, and C. P. West (ed.) 2009. Tall Fescue for the Twenty-First Century. Agron. Monog. 53. ASA, CSSA, SSSA. Madison, WI. 540 pp. Also (http://forages.oregonstate.edu/tallfescuemonograph).

Kallenbach, R. L. (2015). BILL E. KUNKLE INTERDISCIPLINARY BEEF SYMPOSIUM: Coping with tall fescue toxicosis: Solutions and realities. Journal of Animal Science, 93(12), 5487-5495.

Mayberry, K. J. (2018). Evaluation of Genetic Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Phenotypic Variables, Calf Performance and Cytokine Response. Thesis, North Carolina State University.

Melchior, E. A., & Myer, P. R. (2018). Fescue toxicosis and its influence on the rumen microbiome: mitigation of production losses through clover isoflavones. Journal of Applied Animal Research, 46(1), 1280-1288.

Poole, R. K., & Poole, D. H. (2019). Impact of ergot alkaloids on female reproduction in domestic livestock species. Toxins, 11(6), 364.

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