Weaning piglets effectively is critical for farmers to ensure they are healthy and productive. Pigs that do not transition well from milk to a solid diet have their gut health compromised and become susceptible to disease challenges. Ernie Hansen, manager of swine nutrition and technical services at Hubbard Feeds, sits down with Tom Martin to explain the strategies producers can implement to support a successful transition and improve long-term pig production. 

The following is an edited transcript of Tom Martin's interview with Ernie Hansen, manager of swine nutrition and technical services at Hubbard Feeds. Click below to hear the full audio:

Tom:              This is Tom Martin, and I'm here with Ernie Hansen, manager of swine nutrition and technical services at Hubbard Feeds. He joins us to talk about transitioning piglets at weaning from milk to solid food. Thanks for being with us, Ernie.

Ernie:             All right, thank you.

Tom:              What are some of the problems that producers face when they begin weaning piglets from milk and moving them to a solid diet?

Ernie:             Well, helping pigs make a smooth transition at weaning has always been a high priority for pig farmers. Today's high-producing genetics have been selected to wean 30-plus pigs per sow per year and to produce pigs that will reach a market weight at or in excess of 300 pounds, and to do this quickly and efficiently. This performance level and, even more importantly, the way these pigs start on feed is drastically different than pigs from ten years ago.

                        Couple these factors with the known stressors of weaning — weaning age, the physical separation from the mother sow, commingling, transportation, the environment difference, and the traditional milk-to-solid-food transition — and that's a stark reminder that there is no substitute for good animal husbandry for the first week post-weaning. The old adage is certainly as true now as it ever was: "A pig never gets over a good or bad start."

Tom:              What are some of the outcomes seen in a piglet that does not transition well post-wean?

Ernie:             Health is a big factor at this stage of life for the piglet. If pigs aren't eating well, gut health is compromised, and this can affect their overall health and make them susceptible to disease challenges. This requires farm workers to spend more time treating pigs, and depending on how severe the challenge is, there may be an increase in mortality and morbidity as well.

                        We use the term "all-value pigs." This is a reference to the pigs that reached the targeted market weight on time with minimal health challenges. These all-value pigs represent the highest returns for farmers and the greatest opportunity for increased profitability.

Tom:              So, what is the importance of feed intake? What does the producer need to be thinking about as piglets are making this transition?

Ernie:             To make it very simple, intake is everything at this stage of the pig's life. Healthy pigs are very efficient. That means every extra bite of feed is extra weight gain. It's the most efficient and cost-effective growth the pig will experience.

Tom:              Why is gut health critical at this particular phase in a pig's life?

Ernie:             You may not realize it, but the gut is the first line of defense for the young pig and is actually a large part of the immune system. It's a barrier that keeps out bacteria, and if it’s not functioning properly, those bacteria get into the pig's bloodstream and can spread, causing disease challenges for the pig. As more research is done on gut health and gut function, we're discovering that pigs don't always fully recover from the initial attacks on their system. While it may look like they recover and have good performance, research is showing they won't have gains as good as those pigs that didn’t experience the health challenges early in life.

Tom:              So, what steps or management techniques should producers and farmers take to make sure that pigs transition well post-wean?

Ernie:             We work closely with our customers in a couple of different areas to help pigs get started on feed. Frequency of feeding for the first week in the nursery is critical. The more times we can be in the barn feeding the pigs, the better they will start. In some cases, just walking through the barn and getting the pigs up will stimulate them to eat.

                        Secondly, identifying fallback pigs as early as possible — early intervention — helps transition those pigs to get them back on track. Use of a gruel or a highly fortified feed is essential to get the right nutrients into these young pigs.

Tom:              Some pigs are naturally inclined to not eat as well while they're transitioning from a liquid to solid diet, so it's important for producers to do what they can to motivate those pigs to eat more. How does Viligen® play a role in this key part of their transition from milk to solids?

Ernie:             Viligen is an intake stimulant. It's combined with certain nutrients and palatability factors that not only encourage them to eat — to eat more, to take that first bite of feed — but it also has gut health components that help support the gut in overcoming challenges that the environment brings to that pig. So, it causes them to eat more and then supports their health. A healthy pig that eats is going to grow faster and more efficiently throughout its entire life.

Tom:              Tell us about the feeding trials using Viligen that were conducted by Hubbard Feeds.

Ernie:             So, we started Viligen trials about nine months ago (Oct. 2017) after an Innovation Group meeting at Alltech. We did some simple trials and the pigs performed well above expectations. We had improvements in gains that were really quite remarkable. We redid the trial and we duplicated those improvements in gains.

                        In the second trial, we had a significantly higher degree of overall health challenges, and we're able to see that we had not only improvements in intake and gains, but that led to improvements in overall health. We treated fewer pigs for health issues, we pulled fewer pigs out of the pens that weren't starting and we had fewer pigs die in the trial.

Tom:              How big of a role does formulation of feed play at this stage when the piglet is transitioning from milk to solids?

Ernie:             Diet formulation plays a critical role for these young pigs as they transition from the sow’s milk to dry starters. Diets are more complex to supply the nutrients that will promote good gut health, which is important for nutrient absorption and utilization. High-quality ingredients are key to the digestibility of the young pig and also reduce the chance of adverse interactions with other ingredients.

                        Finally, ingredients that promote intake are an important technology to include in the nursery diet. People often think of flavors in milk products to encourage intake, but we're excited about Viligen, which our research has shown to improve intake and health in these young pigs. Viligen — which is a blend of fatty acids, prebiotic components and mineral nutrients — helps condition the gut mucosa, which helps get ready for rapid growth because of the improved feed intake.

Tom:              Ernie Hansen, manager of swine nutrition and technical services at Hubbard Feeds, joining us from Mankato, Minnesota. Thank you for being with us, Ernie.

Ernie:             Thank you much.      

I want to learn more about supporting piglet health and feed intake during weaning. 

Dietary trace minerals like copper, zinc and manganese are nutrients critical to animal health, performance and welfare. Immunity, reproduction, growth and even meat and milk quality hinge on optimal trace mineral nutrition.

Everything we know about trace mineral nutrition, from inclusion levels to effects on performance, has come from studies using inorganic trace mineral salts. Trace mineral salts are made from a trace mineral loosely bound to a charged ion and have been the basis of trace mineral supplementation and research since the 1930s. Recent studies, however, are using a different form of trace mineral, and the results of those studies are challenging ideas once considered fundamental to livestock nutrition.

In the early 1990s, organic trace minerals were first developed to reflect the way trace minerals naturally occur in plants. These supplements have a protein-like or carbohydrate ring structure that attaches to the trace mineral at multiple sites. The protein or carbohydrate component serves as a protective, stable delivery system, increasing the likelihood of mineral absorption.

The last 20 years of research confirm that the difference between a mineral salt and a trace mineral bound to a stable organic ring are substantial. The evidence points to organics as a superior source of trace minerals, but beyond that, we see unprecedented effects in the animal when they receive optimally formulated minerals. Organic trace minerals are changing the way we look at livestock nutrition overall.

Below are seven major changes to nutritional dogma instigated by studies looking at organic trace minerals. While many nutritionists still cling to the low-priced, traditional inorganics, organic trace minerals are fostering a revolution in animal feeding.   

1. Not all trace mineral forms are created equal

Historically, inorganic trace minerals have been the primary form of mineral supplementation. Their inexpensive synthesis, however, produces a supplement that quickly dissociates and reacts within the feed and digestive tract.

Dr. Richard Murphy is a biochemist and research director in Dunboyne, Ireland, who has focused much of his work on characterizing, comparing and optimizing trace mineral supplements.

"When comparing mineral products — both inorganic and organic — the key differentiation point is to understand their stability through the GI tract," said Murphy. "Stability at the acidic pH found in the gastric environment is critical to ensuring maximal delivery of mineral to sites of mineral absorption in the intestine."

Dr. Murphy's work has repeatedly shown that organic trace minerals are far superior to traditional inorganic trace minerals in both stability and overall bioavailability. They are, in fact, so much more efficient that countless animal trials have shown that organic trace minerals can be fed at significantly lower levels than their inorganic counterpart without disrupting health and performance. 

Surprisingly, Dr. Murphy's research has also found that not all organic trace minerals are created equal.

"Ultimately, the type and position of the amino acids used in organic trace minerals are critical for stability," said Dr. Murphy.

Different brands of organic trace minerals use different amino acid and peptide strands, some with far weaker associations and lower stability than others.

Dr. Murphy and his research associates have developed a peptide-trace mineral configuration for use in organic trace minerals that provides optimal stability. It is, in fact, his work in differentiating organic and inorganic trace minerals that has laid the foundation for the six other breakthroughs in mineral nutrition.

2. Inorganics: Not required

The National Academies of Sciences, Engineering, and Medicine (NASEM) publishes livestock requirements for all essential nutrients, among which it lists inorganic trace minerals. New research, however, proves that, while trace minerals are essential, there is no absolute requirement for inorganic trace minerals. In fact, eliminating inorganics altogether and replacing them with organic trace minerals appears to enhance performance. 

In beef cattle, a total replacement of inorganic trace minerals with lower levels (60 percent) of organic trace minerals improved health and performance and generated a $50/head advantage (Holder et al., 2016). Total replacement with organic trace minerals in pigs improved average daily gain, increased slaughter weight by 2 kg and improved slaughter efficiency to generate a savings of $1.80 per pig.

Inorganics may prevent deficiency, but there are far more effective supplement options. Even operations feeding a combination of inorganic and organic trace minerals stand to benefit from converting to 100 percent organic trace minerals. The total replacement of inorganics offers the best results in achieving animal genetic potential.

3. Organic trace mineral bioavailability: using less to do more

Studies routinely feed organic trace minerals at levels 30-50 percent lower than inorganics because the superior delivery system of organics allows them to be more efficiently absorbed. Poultry scientists at the University of Kentucky asked, "Just how much more efficiently?"

In their study, broilers were fed organic trace minerals at levels 75 percent lower than commercial levels for inorganics. These birds reached a desirable market weight in the standard six-week period and showed no signs of deficiency or disease, even though they were fed only one-quarter the mineral ration of their inorganic-fed counterparts (Ao et al., 2009). These relative concentrations are below those traditionally recognized as needed for meeting the birds’ requirements.

Organic trace minerals are more effectively absorbed and deposited in the intended tissues, so small amounts can have a greater impact. The inefficiency of inorganics requires producers to significantly overfeed them. Organic trace minerals offer a way for producers to maximize resources. This research also gives us a clearer picture of what an animal's true trace mineral requirements might be.

4. Organic trace minerals contribute to significant improvements in animal health

Trace minerals have a lock-and-key effect on certain antioxidant enzymes that are critical to immune function. A sufficient supply of trace minerals can be described as the sustaining fuel of the immune system. Recent feeding trials and nutrigenomic studies showcase organic minerals taking on some of agriculture’s most costly diseases.

In feedlot cattle, a total replacement of inorganic trace minerals with lower levels of organic trace minerals (60 percent of commercial levels for inorganics) was able to reduce mortality by 57 percent and mortality due to bovine respiratory disease (BRD) by 69 percent. Even in the cattle contracting BRD, the number of retreats was significantly reduced with organic trace minerals (Holder et al., 2016). Too good to be true? A separate study conducted on a different continent confirmed the effects: organic trace mineral groups showed a 7.7 percent decrease in even the incidence of BRD (Sgoifo Rossi et al., 2018).

"BRD costs the U.S. beef industry upwards of $800 million and is the greatest concern and cause of loss at the feed yard,” said Dr. Vaughn Holder, lead beef researcher at Alltech. “Organic trace minerals provide a new reinforcement to the animals’ first line of defense and add tremendously to the producer’s peace of mind."

In poultry, necrotic enteritis (NE) brings devastating costs, approaching $6 billion annually with mortality rates of 1 percent per day. Organic trace minerals eliminated bird death due to NE, reducing mortality by 12 percent compared to inorganics (He et al., 2017; Bortoluzzi et al., 2017). Birds on organic trace minerals also showed significant positive changes to the expression of genes related to improved disease resistance.

From gene expression to disease markers and mortality, there is mounting evidence that the bioavailability of organic minerals better equips animals to take on and survive disease challenges.

5. Organic trace minerals lead to extended shelf life and improved meat quality

The impact of organic trace minerals spans the entire food chain, all the way to our own refrigerators. Animal nutrition directly affects meat quality, as feeding organic trace minerals results in meat that lasts longer and tastes juicier.

"Trace minerals are essential to antioxidant enzymes in the meat," said Dr. Rebecca Delles, an Alltech meat scientist. "By providing a trace mineral source that is more bioavailable, those antioxidants have a better mineral supply to sustain their activity."

Proving her point, beef from steers that were fed organic trace minerals showed increased antioxidant activity, which led to extended shelf life (Sgoifo Rossi et al., 2018). That same meat also showed increased water retention, which improves profitability and texture. Dr. Delles found that organic trace minerals had the same effect in pork loin and chicken breast, beneficially improving both sensory experience and the producer’s bottom line (Delles et al., 2014; Delles et al., 2016).

"The average amount of time it takes a consumer to recover from a bad meat purchase is three months,” said Dr. Delles. “If the appearance, flavor or texture is perceived as being low quality, it will be another three months before the customer reconsiders purchasing that meat product. In fresh pork, if only 5 percent of U.S. consumers have a bad meat experience, that could still bring a projected loss of 3 percent — or $181,938,556.80 — over the course of 12 weeks due to what might seem like 'just color or texture.'"

6. More efficient organic trace minerals decrease the environmental impact of livestock

Bioavailable organic trace minerals are the exclusive method of sustaining animal performance while simultaneously lowering environmental impact.

The instability of inorganic minerals makes them difficult for the animal to absorb. This often leads to overfeeding of trace minerals and, therefore, excretion of large quantities of minerals back into the environment. These excreted minerals alter what is known as a “mineral footprint” and contribute to soil and water contamination.

The improved bioavailability allowing lower inclusion rates of organic trace minerals has been found to directly reduce the mineral footprint of livestock.

A series of trials conducted by agriculture institutions across China in 2017 found that in swine, poultry and ruminants, organic trace minerals could be fed at substantially lower quantities than inorganics and yield the same performance — but return much lower mineral excretion. The same was not true for inorganics: while low levels of inorganics also reduced mineral excretion, they were detrimental to animal health and reduced performance (Guo et al., 2017; Ma et al., 2018; Qui et al., 2018).

"This type of research changes the way we study animal nutrition,” said Dr. Karl Dawson, ruminant microbiologist and chief scientific officer at Alltech. “These are the solutions we need to sustainably feed our growing populations — benefitting all stakeholders while decreasing the environmental impact of intensive animal production systems."

7. Optimal organic trace mineral nutrition improves herd health, reproduction and performance for multiple generations

Trace minerals have a multigenerational effect. Like other nutrients, trace minerals change gene expression, effectively turning genes on or off, up or down. Those changes in gene expression are heritable — meaning the effects of a mother's nutrition, good or bad, are passed on to her offspring before they even take their first bite of feed. This phenomenon, known as epigenetics, gives producers and nutritionists the power to use nutrition to build their future herd. 

Dairy scientists at Pennsylvania State University studied a herd over three generations and found that heifer calves experienced 10 fewer days of sickness and came into estrus 26 days sooner when their dams were fed organic trace minerals (Gelsinger et al., 2016; Pino et al., 2018). This was true even for heifer calves who didn't consume organic trace minerals themselves, confirming that the effect was solely due to maternal nutrition. Fewer days of sickness are correlated to increased milk production later in life and reaching reproductive maturity almost one month sooner, which is worth approximately $100/head in management costs and a 2-3 percent decrease in carbon footprint.

In beef cattle, calves born to cows fed organic trace minerals showed improved body weight through weaning and again at 205 days, regardless of their own diet (Price et al., 2017). Weaning is one of the most critical stress points in the beef life cycle — but organic trace minerals in utero allowed weaning and young calves to thrive despite their circumstances. While trace minerals can have an incredible impact on a single animal, results like these show potential for strategized feeding for the future herd.

The advent of precision feeding

From feed to fork, trace mineral source makes all the difference. Organic trace minerals provide livestock with an essential nutrient in an optimized form, and the effects of such precision reverberate throughout the entire food chain. With effects on animal health and welfare, producer livelihood, consumer preference and environmental protection, no stakeholder is overlooked. This is the advent of a revolution in precision feeding. Well-timed, optimally designed nutrients can reveal to us an animal's real requirements and allow them to achieve their true genetic potential, so that we can build better herds and feed a growing population.

Click here to learn more about solutions through the Alltech Mineral Management program. 

Citations

Holder, V. B., Jennings, J. S., Covey, T. L. (2016). Effect of total replacement of trace minerals with Bioplex® proteinated minerals on the health and performance of lightweight, high-risk feedlot cattle, Journal of Animal Science, 94 (5), 120

Taylor-Pickard, J., Nollet, L., and Geers, R. (2013). Performance, carcass characteristics and economic benefits of total replacement of inorganic minerals by organic forms in growing pig diets, J. Appl. Anim. Nutr. 2 (e3): 1-3

T Ao, JL Pierce, AJ Pescatore, AC Cantor, KA Dawson & MJ Ford. (2009). Effects of feeding reduced levels of organic minerals (Bioplex) on the development of white layer pullets, Poult. Sci. 88 (Suppl. 1), 197

Sgoifo Rossi, C.A., Ripamonti, G., and Compiani, R. (2018, May). Not all mineral supplements for beef cattle bring same results. Feedstuffs, 90 (5).

He, B., King, W., Graugnard, D., Dawson, K.A., Bortoluzzi, C., Applegate, T. (2017). Zinc source influences the gene expression of zinc transporters in the jejunum and cecal tonsils of broilers challenged with coccidia and Clostridium perfringens., Poultry Science Association Annual Meeting, Orlando, FL, USA, 17-23 July, 2017

Bortoluzzi, C., Lumpkins, B., Mathis, G., King, W.D., Graugnard, D., Dawson, K.A., Applegate, T. Comparative efficacy of dietary zinc sources for the mitigation of the impact of necrotic enteritis in coccidial challenged broiler chickens, Poultry Science Association Annual Meeting, Orlando, FL, USA, 17-23 July, 2017

Delles, R.M., Xiong, Y.L., True, A.D., Ao, T., Dawson, K.A. (2014) Dietary antioxidant supplementation enhances lipid and protein oxidative stability of chicken broiler meat through promotion of antioxidant enzyme activity, Poult. Sci. 93:1561-1570

Delles, R.M.,  Naylor, A., Kocher, A., Dawson, K.A., Samuel, R.S. (2016). Diets with organic trace minerals (Bioplex®) and yeast protein (NuPro®) improved the water-holding capacity of pork loin meat, Midwest Animal Science Meetings, March; J. Animal Sci. 94 (Supple. 2): 65

Guo, Y., Liu, B., Xiong, P., He, J., Gang, L., Xue, Y.,Koontz, A.F., Yu, D. (2017). Effect of Cu Provided As Bioplex® Cu or TBCC for Weaned Pigs, Growth Performance, Tissue Mineral Retention, and Fecal Mineral Excretion, ASAS-CSAS Annual Meeting, 17-20 July, Baltimore, MD, USA, 2017

LX Ma, JN He, CC Hou, JL Qiu, XT Lu, B Liu, G Lin, Y Xue, AF Koontz, DY Yu. (2018). Effect of compound organic trace minerals on growth performance, serum indices and micromineral excretion in fattening pigs, ASAS-CSAS Annual Meeting, 5-8 July, Vancouver, Canada

JL Qui, XT Lu, LX Ma, CC Hou, JN He, B Liu, G Lin, T Ao, DY Yu (2018). Effect of low dose complex organic trace minerals on productive performance, egg quality and fecal mineral excretion of laying hens, Poult. Sci. 97 (e-Suppl. 1): 202

Price, D.M., Arellano, K.K., Irsik, M., Rae, D.O., Yelich, J.V., Mjoun, K., Hersom, M.J., (2017) Professional Animal Scientist 33: 194–204

Gelsinger et al., 2016 Maternal and early life nutrition and calf health

Pino et al., 2017 Maternal and early life nutrition and offspring first lactation

Harvest time is here. During this busy time, remember to not only monitor what’s coming in from the field, but also to think about what could be happening in other regions from which you may be purchasing feed ingredients.

Molds and yeasts can grow very rapidly as the weather warms in the spring and in the heat of the early summer months. But what about the end of summer and early fall? The weather across North America was extremely variable this summer — from extremely hot temperatures to drought to floods, week after week. How do these weather patterns affect the crops, and what should you be looking for in your feed this fall?

It is commonly understood that drought-stressed fields do not yield well. Digestibility and overall quality will be poor from feed grown in drought-stressed areas. Can living organisms like molds grow during a drought? The answer is yes: many species of molds will still grow during a drought, or they become dormant and wait for the right growing environment to return. One example of a drought-tolerant mold is Aspergillus. Many times, Aspergillus molds will appear olive green to yellowish in color on infected plants. Aflatoxins come from the mold species Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are carcinogenic and thrive in hot conditions. Aflatoxin B1 can convert into M1 and can be found in milk. If this toxin is found over a set limit, the milk must be discarded. When fed to livestock, aflatoxins cause liver damage, suppress the immune system and reduce protein synthesis.

What about areas under heavy rain?

Several molds are typically found during summers of heavy rain, including Fusarium, Penicillium, Mucor, Rhizopus, etc. Fusarium is commonly found in both normal growing conditions and during wetter months. Many times, this mold first appears white and will change to a reddish-pink color. Under stress, both in the field and during storage, this mold can form many mycotoxins, including the trichothecenes family (DON or Vomitoxin, T-2, etc.), fusaric acid, fumonisins, and zearalenones. Clinical signs that these are present include immune suppression, bowel hemorrhaging, reduced intakes, poor milk production, reduced weight gains, abortions, conception challenges, vasodilation and even mortality.

The Penicillium molds will typically show blue to greenish in color, or potentially white, depending on the host crop. Penicillium molds will typically infect feed during storage, but abnormal weather patterns — such as heavy rains or, sometimes, cooler temperatures — can cause more mold to form. Certain tillage practices can also influence mold growth. When stressed, Penicillium molds can form patulin, Penicillic acid and ochratoxin. Clinical signs that these are present include edema, rumen upsets, loose manure, bowel hemorrhaging and increased rates of mortality.

This is a minute sampling of the mycotoxin challenges that can exist during harvest in your fields. Remember: the commodities or other purchased feedstuffs that are shipped in by boat, train or truck may present their own mold and mycotoxin challenges. Check the origin of purchased feed to determine what stress or abnormal weather was experienced in that region. Your local dealers, nutritionists or Alltech representatives can put together information on mycotoxin results from other regions. If you want to be especially diligent in lessening mycotoxin challenges, an on-farm RAPIREAD® mycotoxin test or Alltech 37+® mycotoxin test will check your feeds for any concerns. Remember, more information on mycotoxins is always available online at knowmycotoxins.com.

I want to learn more about protecting my feed from mycotoxins.

The following is an edited transcript of Nicole Erwin's interview with Torben Ancker, product manager at Hornsyld feed mill in Denmark. Click below to hear the full audio:

Nicole:         New zinc oxide regulations are expected to shake up the global pig industry. I'm talking with Torben Anker, product manager at Hornsyld, a privately-owned feed mill in Denmark, where he is responsible for developing pig and broiler feed for Danish farmers. Welcome.

Torben:         Thank you very much.

Nicole:         Torben, European pig farmers have been given around five years to phase out the use of zinc oxide in pig feed, per the European Commission’s directive in 2017. Since the announcement, what has the response been from feed producers like yourself?

Torben:         We knew that the ban would come, and we have tried to find solutions. We started a few years ago, actually. We also know that there is no single product that can replace zinc oxide immediately. Where we stand now is that we are trying to find a good combination of feed components and feed additives, so that we are ready when the ban comes.

Nicole:         Why zinc oxide? Why is it so prevalent in pig feed and why is it a problem?

Torben:         Zinc oxide is used in Denmark as 2500 parts per million (ppm) when we're weaning the piglets. It works well to reduce diarrhea and E. coli bacteria and so on, and it also reduces the amount of antibiotics necessary when you are weaning. It’s a nice product. The problem with zinc oxide is that when you are feeding the pigs and you put the slurry in the fields, you will have an extra amount of zinc oxide, which is seen as a toxic component in the soil. You increase the amount of zinc over the years. I don't think it will be a problem before maybe 50 or 60 years, but the next generations will have to deal with that. I think it's a good idea to deal with it now.

                    There are also the health issues because there has been a connection made between zinc oxide and MRSA, which is a disease that some penicillin strains cannot deal with.

Nicole:         Methicillin Resistant Staph.

Torben:         Exactly. So that's the problem with the zinc.

Nicole:         Where else is zinc being used in other industries that it could be significantly contributing to the environment? Is it mainly livestock production that is the culprit, or are there other areas, too?

Torben:         I would say when it goes directly into the soil, then it's mainly because of agriculture — the pig industry — which contributes the biggest amount of zinc oxide. The funny part is that the zinc additive used in feed for slaughter pigs is a huge amount compared to the zinc oxide used during the first two weeks of weaning. I would say we could have made more progress if we just reduced the amount of zinc oxide in the feed for the slaughters, and then we still could have some of the zinc oxide for weaning.

Nicole:         What are some of the current inclusion levels in feed?

Torben:         Normally, we can add 120 milligrams of zinc oxide per kilo of feed. That's a legislation and it's fine. In Denmark, all the feed mills are using phytase. When we are using phytase, we can reduce the amount of zinc oxide. We have already done that, and we have reduced the amount of zinc that goes into the soil.

Nicole:         There are discussions floating around that there should be an alternative to the ban. I've heard quite a bit about phytase. What else are you hearing that is promising as an alternative solution?

Torben:         I think if we look at alternatives to zinc, it will be a combination of several things. We have to look at the management on farm.

                    Also, in my opinion, we should look into the sow feeding. It’s much easier to wean piglets weighing 7 to 8 kilos than piglets that weigh 4 to 5 kilos. With sow feeding, we can do something to get a higher milk yield and then have more uniform piglets. That will also help us.

                    If we look at promising products, the Danish Feed Research Center is now performing some concept tests. There are actually two companies doing quite well. I do not know which company it is, but they are performing quite well. I think that will be very interesting, to see how it comes out, and maybe we can pick some of the elements and put it into our feed also.

Nicole:         Do you expect the European Commission to consider some of these alternative proposals, or do you think that it's just set — the ban is going to happen?

Torben:         I think the ban will happen and, hopefully, we will have some solution when we reach 2022.

Nicole:         I read that phasing out zinc could also lead to higher use of antibiotics. How is that?

Torben:         If you look at the Danish pig industry today, if we had to stop using zinc now, it would lead to a higher use of antibiotics. In Denmark, we already use a very low amount of antibiotics compared to other pig countries, like, for example, the Netherlands, Spain and Germany. We have very low use of antibiotics, and our government will not allow us to use more. We really need to find a solution that allows us to still have high-performing pigs with less diarrhea and no welfare problems. That's what we really need to have, because the pig industry in Denmark does not earn that much money, so farmers cannot afford to have reduced production when zinc is banned.

Nicole:         The U.S. had just implemented the Veterinary Feed Directive to limit antibiotic use in feed, and a lot of the conversations that I was having went back to Denmark. It's my understanding that Denmark was one of the first countries to impose a feed directive for antibiotic use. It would seem that the possibility for increased antibiotics as a result of banning zinc might encourage an alternative. Or is this a new argument that's coming forward — that removing zinc could increase antibiotics?

Torben:         It's well known that if we are taking the zinc oxide away, then we will use more antibiotics. I also think that the use of zinc oxides has become more like a reflex for some farmers. In Denmark, we have some really nice farms — well-managed with a high health status. I think they could take out zinc oxide tomorrow. Maybe 20 percent to 25 percent of the Danish farmers could do that. I don't know, because it's just like an assurance that the problems would not come.

Nicole:         Well, these farms that you're talking about, what are some of the management plans they've implemented that would allow them to remove zinc?

Torben:         The Danish farmers are quite efficient — they have 35 piglets per sow — and in the last several years, they have been able to build more space for the piglets. I think that’s the reason that some farmers can wean without zinc oxide. There are still a lot of farmers whose animal density is a little bit too high, and maybe they have not been able to develop the pens and all that, so it’s not perfect. But I think 20 percent of farmers would be okay and would be able to do it.

Nicole:         What about spraying dried plasma as an alternative in piglet feed? Have you heard much about this?

Torben:         In my opinion, that could be a part of the solution, because it's a product that helps the pigs to build immunity. I think we have seen some good results using that in Denmark, but it could be a part of the solution — ­but not the only thing.

Nicole:         I read that there were some concerns about biosafety, particularly during periods of emergence or reemergence of swine diseases in different regions of the world — the recent porcine epidemic diarrhea virus outbreak in North America, for example. With resistance diseases looming in the industry, what kind of research do you expect to emerge in response to the zinc ban? Do you think that there could be new solutions as a result of being forced to find an alternative?

Torben:         Yes, I think new solutions will emerge from this. I think we should have started years ago because, while I think we have all the tools, we have not been able to put them together correctly. Also, I think that we have to look at the way we produce. It should not only be a bulk production. But, of course, the consumers have to pay for it.

Nicole:         So, do things like a zinc ban force the industry to rethink things? Otherwise, you kind of stay complacent.

Torben:         Yeah, they have to rethink how they do things. I think they will develop a lot of tools to handle this situation.

Nicole:         From what I've read, it seems like a lot of people know that zinc contributes to gut health, but they don't really know how it contributes. So, if that's the case, how did it end up in pig feed in the first place?

Torben:         Zinc has always been seen as a very important building material for the pigs. Danish research has shown that, in the first weeks after weaning, the piglet actually needs large amounts of zinc oxide to develop good gut health. It seems that this has been forgotten. I think the most important thing is that it goes into the soil, and that is a thing that we have to look at, even though the pigs need it.

Nicole:         Lastly, if this moves forward, to anticipate whatever the feed industry comes up with to cope with the ban, could it potentially lead the U.S. and other parts of the world in a similar direction?

Torben:         I could hope so, because if we could have solutions, then they could be applied in the U.S. also. In Denmark, we haven't been using growth promoters for many years. Maybe it would be good to have a look at that also.

Nicole:         What are you looking forward to in the research in trying to find alternatives?

Torben:         Reducing zinc oxide is an easy solution, but the feed industry faces a lot of difficult challenges in handling this. On a feed mill like ours, we need the prescription from the vet. We have to deal with that before we can load the feed for the farmer. It's like going to the pharmacy — he needs a prescription. In our production, we need to have thorough cleanings, so we don't carry over zinc oxide to the other feeds. I'm actually really looking forward to getting rid of zinc. All these technical things would be much easier for us. Zinc can be toxic, so I think it would be nice to have a solution with fiber, highly-digestible proteins, milk powder, etcetera. If we could use that, I think we will get better results in the end.

Nicole:         I'm talking with Torben Ancker, product manager at Hornsyld. Thank you so much.

Torben:         You're welcome.

I want to learn more about using organic trace minerals on my pig farm.

Today’s pigs have come a long way from those of even 20 years ago. A better understanding of genetics, nutrition and substantial research have all played a significant role in improved performance, reproduction and overall swine health. So, it begs the question: Have swine housing and management technologies kept pace with the modernization of today’s pig?

According to Steve Toft, Hubbard Feeds swine specialist, they have. We sat down with Steve at the 2018 World Pork Expo to collect his insights.

What’s new in housing, equipment, technology or swine management that’s leading to improved performance and animal comfort?

In wean-to-finish barns, there seems to be greater focus and a higher level of intensive care given in the first few weeks after arrival. Examples include:

• Brooders: These lamps are designed to increase comfort and growth rates in pigs by keeping them warm and reducing stress.

• Comfort mats: This addition can significantly reduce the number of pigs commonly lost during farrowing by keeping crates warm, dry, safe and clean.

• Gruel feeders: This type of feeder is commonly considered the fastest and best way to get problem fallback pigs eating and drinking properly after weaning.

• Nipple bars: This innovation provides an extra water source for pigs starting on wet/dry feeders. 

• Pulling pigs: Pigs that are falling behind in terms of weight or health are removed from their group and placed in the fallback pen, so they can receive more specialized care.

Multiple hand feedings are also being conducted several times per day in an effort to stimulate pigs and get them onto feed quickly. Drip valves with nozzles above the cup waterers are also helping to provide ample, cool and fresh water to pigs for the first few days after arrival.

Historically, ad-lib sow feeding — where, as the name implies, the sow can manage her own consumption — in lactation has been a successful tool for maximizing sow performance. Manufacturers are improving these feeders to make them easier to manage and utilizing sensors and electronic controls to monitor intake.

Farrowing crate flooring has also come a long way with cast iron and tribar. This modern flooring features larger, solid, flat surfaces (compared to woven wire), which provide better sow comfort.

LED lights have made a dramatic improvement to swine barn lighting in the last few years, saving electricity and providing a safe, well-lit environment for both pigs and herdsmen.

In addition, better transport trailers have been designed for pigs, which lowers stress while loading/unloading and during transport. They have improved ramps and doors, better airflow and floors for traction, are well-lit and have on-board cooling systems.

What management strategies are producers implementing to create the best environment for their pigs?

• Air filtration: Producers are investing in sow barn filtration technology, especially in moderately hog-dense areas. This has been helping to reduce the spread of disease.

• Ventilation: New control systems are available, which provide more information, are considered failsafe, and offer remote monitoring capabilities to ensure optimal environmental conditions.

  • There is also a trend of increasing ventilation rates when feeding high, lean, fast-growing genetics. Tunnel-ventilated barns are the most common type. These facilities utilize ceiling inlets and fans to create uniform air distribution to aid in cooling pigs down during warm weather.

These are just a few examples of the many ways that producers and industry experts are working to keep swine management practices up to date. Perhaps you found yourself nodding in agreement with the practices utilized on your farm or maybe you discovered some new ideas that might improve your operation. Animal husbandry is certainly fast-evolving and I expect this trend to continue for years to come.

Have a question or comment?

Build a strong foundation for performance and profitability with Alltech’s latest in-feed technology

[LEXINGTON, Ky.] – Global animal health and nutrition company Alltech has assisted pig producers in achieving efficient growth and profitable performance in their animals for nearly four decades. Alltech’s latest technology, Viligen™, which officially launched at ONE: The Alltech Ideas Conference, focuses on enhancing gut form and function while optimizing the immune system to maintain health status.

For producers with weaned pigs, Viligen promotes gut health by directly targeting the gut mucosa. When the technology is added to the diet of piglets, it prepares the immature gut for efficient nutrient absorption and rapid growth, and it encourages feed intake by providing fatty acids, prebiotic components and readily available mineral forms.

“Viligen is the first product of its kind and will be available in all Alltech markets,” said Dr. Jules Taylor-Pickard, global species director at Alltech. “Pig producers will notice better intestinal health in their piglets, which will lead to better animal performance. Viligen will also drive feed intake and support health and survivability.”

By promoting gut health, Viligen is designed to help more pigs reach market weight. As demonstrated in commercial research, piglets consuming Viligen have improved average daily gain and average daily feed intake. Increasing feed intake in the piglets optimizes performance and provides a sturdy platform for optimal health, specifically gut health.

Alltech has developed a technology that addresses all profit and production aspects of nursery pig nutrition, including feed intake, body weight gain, piglet health, survivability and improved numbers of all-value pigs.

Viligen pairs well and works in combination with other Alltech solutions. It is a part of the Alltech^® Gut Health Management program and the Alltech Antibiotic-Free and Alltech Antibiotic Reduction programs. Viligen is a perfect complementary product that will help pigs produce the energy needed to absorb nutrients in the feed.

“So far, feedback from Viligen use on U.S. pig farms has been very positive,” said Russell Gilliam, U.S. swine business leader at Alltech. “At Alltech, we understand that pig producers with weaned pigs are looking for technologies and solutions that lower production costs without compromising on performance.”

For more information, visit www.alltech.com/viligen.   

The following is an edited transcript of Tom Martin's interview with Dr. Anna Catharina Berge, veterinarian and owner of Berge Veterinary Consulting. Click below to hear the full interview:

Dr. Anna Catharina Berge, owner of Berge Veterinary Consulting BVBA, is a veterinarian with extensive knowledge and skills combining real-life animal husbandry with epidemiological perspectives of animal and public health challenges. Berge joins Tom Martin from Vosselaar, Belgium, to discuss the use of, and alternatives to, antibiotics in pig production.

Tom:                          Let’s begin with pig production. Is antimicrobial use in pig production a real threat?

Catharina:                 All antimicrobial use has the potential to increase antimicrobial resistance in bacteria. Antimicrobials are really vital to humans and animals to protect against bacteria that can cause disease or death. Antimicrobial resistance is threatening the efficacy of these valuable drugs to treat bacterial disease. Even the World Health Organization (WHO) stated in 2014 that the antimicrobial resistance situation is so serious that we are entering a post-antibiotic era in which common infections and minor injuries can kill. This is far from being an apocalyptic fantasy — it’s a very real possibility for the 21^st century. This is not just some journalists writing up some fearful scenario. This was the WHO. So, it is a real threat.

                                 Microbial resistance in pig production is usually a consequence of decades of antibiotic use for disease prophylaxis or growth promotion. The antibiotics administered are not completely absorbed by the animals. If you’re giving an antibiotic to an animal, 30 to 90 percent of those antibiotics are actually excreted through the urine or feces. The antibiotics can reach the source through medical waste, improper drugs or even from dust from pens in barns. These antibiotic residues can also impact the environment and disturb the delicate ecological balance.

                                 Antibiotic-resistant bacteria may also spread into a virus through other mechanisms. Antibiotic-resistant bacteria may also spread to humans through food or through the environment. These antibiotic-resistant bacteria don't just disappear if we stop using antibiotics. They tend to linger. They’re easily created, but they don't tend to disappear quickly. Therefore, we need to do everything to not increase this pool of resistant disease that can spread between different types of bacteria. These resistant diseases can spread from bacteria that are not dangerous and just hanging around in our dust to those bacteria that are really causing disease and even death. If that resistant disease finds bacteria that cause death, then we have a bacterial disease that can’t be treated, and we may die from it. So, resistance is dangerous.

                                 Antibiotic resistance is also an increasing challenge on many pig farms because producers are noticing that good old antibiotics are not working any longer because bacteria become resistant to them. So, they use newer and newer antibiotics. And this newer antibiotic is what the WHO now calls critical antibiotics, those that we want to maintain to treat humans against dangerous disease, so we’re building up resistance to all of these newer antibiotics. The problem is, there are really no new antibiotics created today. The pharmaceutical industry has stopped investing in the research and development of new antibiotic drugs, so we're running out of good drugs to treat bacteria.

Tom:                          You have noted that herd-level immunity, individual pig gut health, systemic immunity, nutritional status, stress levels, and environmental conditions all interact. Why is it important to understand these interactions?

Catharina:                 No animal, organ or cell works in isolation. They all work closely together and, hopefully, in harmony. They all influence each other. So, a pig, furthermore, is living within a very complex production system where you have various factors that can influence its health and productivity. So, unless you take the whole system into account and evaluate this whole system, you don't really know the cost of a disease or why the pig is not doing well. You may think the cause is something other than disease, but it’s really the disease as a consequence of the production system.

                                    Our production systems have not been optimized for what the pig needs and what we want from the pig. We are trying to adapt the pig to our production systems instead of adapting our systems to the pig. This is creating a problem, and one of the solutions has been to medicate with antibiotics.

Tom:                          What challenges do antibiotics pose to the gut health of pigs and livestock?

Catharina:                 Antibiotics can prevent bacteria from reproducing or destroy bacteria. These antibiotics don't differentiate between bacteria that are good for the body and those that are potentially harmful. Some antibiotics work on different threats to the bacteria and some can work against a lot of bacteria types. Others work against just a few.

                                 Many of these antibiotics are used in the feed in pig production for extended periods of time. They have what we call a broad spectrum. They work against a lot of different bacteria. An example of such is tetracycline. These antibiotics can modify the gut flora and reduce diversity of the bacteria in the gut. Therefore, many good bacteria that are helping in many different ways are killed. Some harmful bacterial also are killed, but when the good gut flora is destroyed, then the pathogenic, harmful bacteria have a bigger chance to reproduce and attack the intestinal lining, maybe even invade the body and cause disease. It’s really essential to create a good microbial flora in the pig, and these antibiotics can actually work against them in that way.

Tom:                          Globally, farmers are now showing that it is possible to reduce antimicrobial use without sacrificing performance in health. A key focus has been placed on gut health. Why is gut and intestinal health in pigs so important?

Catharina:                 It’s key to a healthy animal. The gut is responsible for the digestion and absorption of nutrients that are necessary for the whole body to function properly. Through the food ingested, the pig gets energy — macronutrients and micronutrients — to fuel and support the functions of every single cell in the body. So, if the gut is not working, then the pig’s overall health will suffer.

                                  It’s in the gut that the immune system encounters many potential pathogens that are harmful bacteria. These need to be stopped before they start destroying the intestinal linings or invade the body. In the gut, we have the most immune cells of the whole body. This immunity has high requirements for energy and nutrients and must be in top shape for protecting the pig. If you don't have good gut health, then the immune system doesn't have enough energy to do good work.

                                 A healthy gut, furthermore, has a microflora of bacteria that participates in the digestion of many nutrients. These healthy gut microflora also prevent pathogens from growing and invading intestinal cells. This microflora shows a high level of diversity, and every bacteria species influence each other. So, the healthy gut microflora is also critical to a healthy gut.

Tom:                          What do you think will be the best measures to reduce antibiotic use?

Catharina:                 I like the holistic approach. The best measure to decrease antibiotic use is to optimize the production system and nutrition to better meet the pig’s basic needs.

                                 A first step is to create awareness of the consequences of our antibiotic medicating system and motivate people to change. It’s important for producers to understand that reductions in antibiotic use can be made without compromising the health of the animal or their productivity. But it requires an evaluation of the whole production system and nutrition to identify the weaknesses in every single system because every single system we enter is different.

                                 The easiest part to change is nutrition for the pig and making sure that it’s correct for every single stage of its life and that the pig is not exposed to high levels of bacteria or mycotoxins in the feed and the water. Thereafter, we are starting to look at management changes and housing changes to meet the physiological needs of the animals and protect them from disease from inside and outside the unit. That’s also called “biosecurity,” and that's very important. Thereafter, we need to start looking at how we can boost immunity so that the pig is then able to meet all the challenges.

Tom:                          Among the farms you are working with, what percentage of reduction do you think is realistically achievable?

Catharina:                 I would say most farmers across the world are still using a lot of antibiotics prophylactically to prevent disease, or they use it for growth promotion. And I believe that all of that use can stop. There, again, there has to be a motivation of the producer to change. But, in general, if we go onto a farm, a realistic goal we usually can see without too much of a challenge is a 50 percent reduction in antimicrobial use already within the first year.

Tom:                          What are the components that should be included in any antibiotic reduction program?

Catharina:                 There was a philosopher in 1850 that said if you don't record it, you can’t improve it. So, you have to have an antibiotic use registration system and you have to evaluate it. It’s not enough just to jot down a few notes in a book somewhere. You have to evaluate. Then you have to set targets. You have to ask, “How can I achieve this reduction with those targets?” You need to look at the appropriate nutrition for every single stage of production. All the pigs, based upon where they are and how old they are, have different needs. You need to have appropriate nutrition. You also have to have very good, quality feeds — low microbial levels and low mycotoxin levels. Then you need to look at the management level. How are you moving the pigs around the system? Are you weaning them too young? Are you stressing them at different phases by mixing litters, and so on? So, management systems are very important.

                                 Housing systems need to be evaluated. Many times, we have pigs in old systems where it’s really not optimized for holding them, and we may need to consider rebuilding on a long-term scale.

                                 A very important part is biosecurity. Biosecurity is what we call “disease protection.” You need to protect the animals from disease that is found inside the uterus. That’s called “internal biosecurity.” You also need to protect the pigs from diseases that are not on the farm currently, but could be introduced by animals, vehicles and people. That’s called “external biosecurity,” and that's very important.

                                  You also need to be able to correctly diagnose and treat the clinical diseases in the best way. People don’t always understand what they're seeing and how it should be best treated.

                                 And of course, we have the alternatives to antibiotics that are valuable tools to support health and productivity. We have products that can support microflora in the gut and optimize the strength of the gut lining such as Bio-Mos® and Actigen®.

                                 We have alternatives to boost immunity. Vaccines, for example, are vital to protect the pigs against many diseases. Organic minerals are important to boost the immune system and help the immune system work optimally. So, all of those components are appropriate and are very important to consider in a program.

Tom:                          You have suggested that the goal to reduce antibiotic use should be rephrased to a goal to produce healthy production systems. How do producers look at this challenge as an opportunity instead of a threat?

Catharina:                 Well, I think for that exact reason: Health is not a threat. It’s something we all strive for, whether in our bodies, a healthy business, healthy ecosystem or healthy planet. And producers are realizing more and more that diseases are costly. Furthermore, there is no joy in working with sick animals. Honestly, I have yet to meet a pig producer that tells me that he or she wants to use antibiotics. It’s rather that they believe it's necessary to prevent disease. When we start showing that we can remove the antibiotics without suffering productivity losses or increased diseases, then they start seeing the possibility of moving toward a more sustainable production.

Tom:                          Can you expand on the practical measures a pig operation could implement to develop a healthy production system?

Catharina:                 I would recommend any pig producer that wants to develop a healthy production system seek out a team of experts: consultants, nutritionists and veterinarians who can evaluate the whole system. That is what we call a “whole herd audit.” This audit usually takes at least a day. Based upon this initial audit, there will be various points to address, whether in housing, management, nutrition or disease treatment. You start setting up the concrete plan of what major issues to address and what targets to achieve.

                                  Everyone involved in production, as well as nutritionists and veterinarians, needs to be involved in an antimicrobial reduction plan. Once you’ve set up this plan and you start implementing, it's really important that you have a very good follow-up. Therefore, you should have regular audits to monitor the progress, create accountability for effort and set up new achievable targets as necessary. Alltech has actually developed such a holistic antimicrobial reduction audit.

Tom:                          What is the future of antibiotic use in the pig industry?

Catharina:                 I hope that the pig industry will move toward reducing antibiotics very quickly so that the consumers are not forcing them to completely ban all antibiotics. The future of antibiotic use, as I see it, is that antibiotics will be available for individual treatment of sick pigs or serve a metaphylactic use in the exceptional cases. But all prophylaxis or regular continual use such as growth promotion is stopped.

Tom:                          In the past couple of years, we've seen some significant increases in the presence of mycotoxins in haylage, barlage and silage. Why are mycotoxins important to consider when we're talking about antibiotic reduction?

Catharina:                 Mycotoxins are produced in various unfavorable conditions. As you mentioned, we see them more and more emergent in all our feed sources. They’re very toxic compounds, and they can impact both immunity and health. There are various types of mycotoxins present in most feeds in various levels. We have seen in audits of many pig producers that an underlying reason for poor health and productivity is a high level of mycotoxin exposure.

Tom:                          What kind of effects do mycotoxins have on pigs?

Catharina:                 That is one of the problems — that people don't realize that they have a mycotoxin challenge in their production because the signs are very subtle and diffused. There are various symptoms that the producer does not recognize. Some of these symptoms are, for example, poor feed efficiency, suboptimal growth, digestive distress, various disease problems and poor reproductive performance. Mycotoxins have strong immune suppressors, and that’s one of the reasons why we see more and more disease and why the pigs are susceptible to disease.

                                 All of these mycotoxins — there are many — have different modes of action. But there’s seldom just one mycotoxin present in the feed. There’s usually multiple. When they’re working together, sometimes they can have an additive effect, but sometimes they will have a multiplicative effect. The gut and immune system are first to encounter the mycotoxins once ingested. We have talked about the importance of gut health and antimicrobial reduction audits and programs. It’s essential to address this risk as an aspect of the reduction program. We have always seen in our antimicrobial reduction audits that when we go in and address these mycotoxin challenges and feed through the inclusion of a good broad-spectrum mycotoxin binder such as Mycosorb®, then we see improved productivity.

Tom:                          What consumer demands are driving significant changes in the industry?

Catharina:                 Consumers have high demands on the industry. Today’s consumers want food from animals from a sustainable, animal-friendly system. They also want food from animals that have not been medicated with antibiotics. We have seen that consumers are actually willing to pay a higher price for meat produced without antibiotics.

                                  Animal welfare is another area that has a very high importance for consumers. Measures such as tail docking and castration are increasingly questioned. Since these interventions are often coupled with an antibiotic injection, systems where castration and tail docking are not necessary will have reduced antimicrobial use. Tail docking has been performed to reduce the incidence of tail biting in group-housed pigs. If the animal environment is improved, it is possible to rear pigs with their tails intact. That is the case in Sweden, where tail docking is banned.

                                  An improved group housing system will reduce antimicrobial use in growing pigs. Another area is the group housing for gestating sows, so they don’t stand locked up in small crates all their life. This is also highly desirable by consumers. This also optimizes the health and strength of these sows, and they can rear healthier piglets. The animal welfare requests of consumers contribute to healthy animals that do not need antibiotics. 

Tom:                          Dr. Cat Berge of Berge Veterinary Consulting BVBA in Vosselaar, Belgium. Thank you so much for joining us.

Have a question or comment?

Below is a transcript of Tom Martin’s interview with Dr. Karl Dawson, vice president and chief scientific officer at Alltech and co-director of the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition.

Click below to hear the full interview:

                                    Over the last 10 years, scientists at Alltech have been using nutrigenomics to define a variety of new nutritional concepts, manage product development and redefine our view of nutrition. What are the practical applications of the science, and what does it mean for the future of feeding and farming? Tom Martin talked with Dr. Karl Dawson, vice president and chief scientific officer at Alltech.

Tom:                          Let’s begin with the question: What is nutrigenomics?

Karl:                            Nutrigenomics is a system for looking to see how the environment, disease processes and nutrition influence gene expression in an animal. This is taking the basic information that comes in an animal’s genetic makeup, its DNA, and looking to see how that's used. This system allows us to look at numerous genes at a time. And in some of our studies, we would be looking at as many as 25,000 genes at a time. So, we get very precise in our measures of what the environment, or disease — or, in this case, nutrition — does to that animal.

Tom:                          In a recent panel discussion, the webinar “Farming the Future,” you said that nutrigenomics is really going to redefine things, if it hasn't already. Can you elaborate on that?

Karl:                            Yes. We’re going to be looking at nutritional processes in a totally different way. We could also look at things like diseases in a different way. The way we look at nutrition today is based on a narrow group of responses in an animal to a nutritional strategy. Nutrigenomics allows us to do that same kind of thing while looking at many, many different characteristics at once and very rapidly. We can look at changes induced by nutrition within several days instead of waiting for a whole production cycle, which may take anywhere from 42 days to two years.

Tom:                          The name of the field, nutrigenomics, might lead us to believe that it’s limited to exploring how nutrition influences the expression of individual genes, but is it more than that? Does the science also look at disease and environmental factors and how they’re related to nutrition?

Karl:                            Yes. We can look at all of those things and how they're related. “Nutrigenomics” may be a misnomer. In the science world, we call it “transcriptomics,” the idea of looking at these genes and how they're transcribed. But the word “nutrigenomics” has taken off, and it’s really being used to describe just about anything to do with gene expression and factors that influence gene expression.

Tom:                          How is this tool being used to define new feeding strategies?

Karl:                            We can talk about a couple of examples that have developed over the last seven or eight years. One of those is the feeding of young animals. We could take a chick during the first 96 hours after hatching and change its nutrition — by limiting its nutrients, we can change how that animal performs throughout its life or its nutrient requirements throughout its life. We would not have been able to know what that looked like until we had this nutrigenomics tool.

                                 We can show that the gene expression pattern changes in a young bird when you've limited its nutrients, but those changes that take place in that gene are reflected throughout the life of that bird. So, some 24 days later, that bird has a totally different environment that it is working with, and the types of nutrients it requires have changed. It's a totally different animal when it comes to its nutritional requirements.

Tom:                          And does this bring more consistency, more precision to farming?

Karl:                            Yes. It’s going to bring a lot of precision, but it actually gives you a new tool because, in some of those changes we’re seeing, we can decrease the amount of nutrients that animal is requiring. You condition it to a low nutrient value or nutrien. As it grows, it’s expecting that as it goes on through its life. So, for example, its mineral requirement may be decreased by as much as 50 percent. That’s a totally different world for that animal to grow in, and it changes the way we feed that animal to optimize its performance and health.

Tom:                          Let's say there's been a blood draw or a tissue sample taken from the herd or the flock on the farm and brought to the lab to process. How long does it take to get that information back to the farm?

Karl:                            It only takes about 48 hours for us to process a sample, but I don't want to mislead you here. We would not necessarily use this as a diagnostic tool at this point. Today, it's a research tool to show you what changes happen with a new trend. We can use it to screen new nutritional strategies or look at nutrients in the way they're influencing that animal. Eventually, you’re going to see some diagnostic tools coming from that. But today, that probably isn't a very realistic approach for this type of technology.

Tom:                          What are some new commercially useful feeding concepts that have come directly from the use of this molecular tool?

Karl:                            A couple come to mind immediately. One of them has been a rather surprising observation. Often, in the growth of that young animal and growing livestock, we’ll use enzyme supplements. The idea behind using an enzyme supplement is really to change what is happening to the food, how it's digested. Well, one of the surprising things that we found using nutrigenomics is, that is reflected not only in the digestion process, but actually the way the tissue develops in that animal. It changes the receptors for hormones. It changes the way that animal responds physiologically.

                                  That technology has moved forward and is the basis of a couple of different programs that we’re using in beef cattle today — to use enzymes to enhance their growth and performance. In some systems, we found that this can be worth as much as $15 to $20 per head when that animal reaches its final stages of growth or finishes out and goes on for beef production. So, it's a pretty substantial thing. We never would have seen that, or even thought about doing that, if it hadn't been for that nutrigenomic tool that allows us to see those changes in those animals.

Tom:                          I also recall from the webinar, “Farming the Future,” some discussion about the influence of minerals.

Karl:                            Absolutely. Minerals are very important, and that's one of the areas that probably was the hallmark of our nutrigenomics work when we started out. One mineral, specifically, is selenium. Selenium is a nutrient that's very important, but we had no idea of how much or what the ramifications of feeding selenium really were. We found all sorts of hidden traits that are influenced by selenium, all the way from reproduction to the development of brain tissue and the speed at which an animal grows.

                                    One of the most interesting traits is the way that animal generates energy. We found very early on that we could change the function of the mitochondria and the cell. This is the energy-producing organ within that cell. We can increase its efficiency by about 15 to 20 percent. That doesn't sound like a big number, but using a dairy cow for example, that means we can improve its energy efficiency by that same amount, which probably means 2 to 3 liters of milk a day from a cow.

                                 So, this is turning everything upside down. We've changed what we thought we knew about energy metabolism, and it's a totally different world now. We're going to have to go back now and redefine energy metabolism — not based on the energy content of the feed, but based on these minerals and the way they are interacting with that energy source.

Tom:                          Let's say there's a new feed supplement out there on the market and you want to determine its value as quickly as you possibly can. Can nutrigenomics do that?

Karl:                            Absolutely. That’s one of the most exciting examples I have right now. Several years ago, we were asked to come up with an alternative antioxidant to help us address the shortage of vitamin E. We took a nutrigenomics approach to that issue and developed what we thought was a new material to serve as a booster for vitamin E activity. Normally, to evaluate a new antioxidant system like that, we would have done it over a period of several years. It takes time to grow the animals, look to see what the vitamin E is doing, to harvest the meat product and evaluate the way that is responding to oxidative stress.

                                    With a nutrigenomics approach, we were able to do the same types of evaluation, but we can look at gene expression as our measure. In doing so, we could shorten that two-year period to about six weeks. We could actually evaluate what that new ingredient was doing during that very short time.

Tom:                          By applying this tool, you're gaining a lot of information, a lot of knowledge. How does that information influence the way you think about nutrient requirements?

Karl:                            We’ve changed a lot in terms of nutrient requirements. We talked about selenium a minute ago. We used to have a fairly standard idea of what selenium requirements were. Using nutrigenomics, we’ve been able to redefine that, and found that by changing the form of selenium — by putting it in the form of a selenium yeast, for example — we could decrease its requirements by about 50 percent.

                                    We’ve gone on to look at all sorts of different minerals. We know that we can cut back on a lot of the requirements we expect for copper and zinc in the diet. We can cut those by as much as 75 percent. So, we have really started to change that. Instead of asking what a mineral is doing, we look at the form of that mineral as well as how much we're providing it. Again, it’s turning things upside down. The old requirements we had for some of these minerals have really changed.

Tom:                          How is nutrigenomics being used to demonstrate the effects of maternal nutrition on the growth or development and the disease resistance of offspring?

Karl:                            This has been another very exciting area. We did some studies several years ago in pigs — looking to see what would happen to the offspring if we fed a particular carbohydrate or supplement to the sow. We fed the sows a particular carbohydrate called Actigen^®, which is a yeast product. Then, we looked to see what was happening in the piglets. To our surprise, by looking at the gene expression in those piglets, we could easily differentiate the piglets that came from the sow that was fed that material. In fact, we found some very specific genes were being changed. One of the more interesting effects was to the hormones that influenced the ability of that young pig to eat.

                                 We could stimulate intake in those young pigs, not by feeding the young pigs the material, but by feeding the sow. That changes what we think in terms of overall production, because now we have a different animal to work with. They have different gene expression patterns and, in fact, different nutrient requirements. Their resistance to specific diseases has changed.

Tom:                          Does this enhance that consistency that we were talking about earlier across generations?

Karl:                            Yes. That's the idea. We've always thought that consistency occurs, and we have evidence of it in the human population — that you are what your mother eats. Nutrigenomics actually gives us the tools to see what is changing specifically, and to program that into the production process.

Tom:                          We've been talking about animals here as though they were something separate and apart from us, but we're animals as well. Does nutrigenomics influence the way that we think about human nutrition?

Karl:                            Absolutely. We’ve really projected into the human population from what we've done in animals with nutrigenomics. One of the star programs that we have right now is a set of compounds that we've developed to provide a preventative for Alzheimer's disease. This program came directly from our observations of what was happening to gene expression. We realized that the genes that were being expressed — or not being expressed — in Alzheimer’s patients were, in fact, associated with Alzheimer’s and the development of neurological tissue. We were able to track that relationship down, and it’s in clinical studies today.

                                 We've done similar things with some of the yeast products that we’re using. We know that they influence animals. We are now doing the same types of nutrigenomic studies in humans to evaluate how these might be useful to address health issues.

Tom:                          I know from past conversations with you about the science of nutrigenomics that you feel that it holds a lot of promise. What is your take home message about this science?

Karl:                            That this is an extremely powerful tool. It probably gives us more information and more precision for feeding animals — and probably even humans — in the future. It’s going to be a very powerful tool for changing the way we develop our feeding strategies. So, my take home message is, “This thing is going to be something that will influence the way science changes our nutrition.”

Pig producers are well aware that enhanced gut health is the driving force behind profitability. Mortality, feed efficiency, growth and health costs are just a few of the many areas influenced by achieving optimal health. Positive gut health can have long-lasting effects on animal performance, herd health and producer returns.

In this webinar, Dr. Stewart Galloway, senior swine nutritionist at Hubbard Feeds, discussed the lifetime impacts of gut health strategies implemented early in the life of the pig. According to Galloway, gut health is a critical success factor that affects things such as pig value — as a source of profit and as a source of protein globally — sow productivity, animal welfare and the responsible use of antibiotics.

Gut health is essential for building a foundation for performance and profitability in pig production. Healthy pigs will eat and produce more efficiently, ensuring they are performing at their maximum potential.

What is the ideal gut?

The goal is to help generate a fully developed gastrointestinal system in which water, pH and beneficial bacteria are balanced and maintained while pathogens and toxins are kept out.

So, how you can tell if a pig’s gut is healthy? To start, observe pig activity. Are the pigs alert and moving around? Are they eating? Are they displaying normal behavior? Another indicator is diarrhea. Diarrhea is a telltale sign that something is not right with the pig’s gut, so it is important to keep an eye out for pigs that have this symptom. Other indicators of a healthy gut include lower morbidity and fewer treated pigs as well as growth and feed efficiency.

However, it is important to remember that many factors can disrupt good gut health. For example, weaning is the biggest stressor put on a pig. Poor gut health strategies implemented at this stage of life will negatively impact the pig throughout its lifecycle. Dietary changes, pathogens and mixing, and crowding stress are some of the other factors that negatively affect gut integrity.

Tips for good gut health

Galloway suggests a comprehensive program approach by implementing these three strategies for good gut health:

1. Decrease gut inflammation

2. Decrease pathogens

3. Decrease water loss

When a gut is inflamed, several problems arise: nutrients are not properly absorbed; there is an increase in antigens, leading to further inflammation; pathogens and toxins move right through the cells, causing inflammation inside the cell; and there is water loss and water movement out of the cells into the gut, leading to dehydration and diarrhea.

To combat inflammation and in turn decrease pathogens and water loss, producers should do a few critical things. First, identify the pig’s stressors and decrease stress. Second, optimize ingredient selection and combination, such as proteins and amino acids, as well as the use of carbohydrates. Third, use enzymes to draw more nutrients from the feed, making them more available for absorption by the pig for its own use and less available for the pathogens to use as a food source later on in the gut.

Achieving and maintaining a healthy gut is a continuous process and requires a complete approach to gut health, not just a one-time or quick fix. An animal truly never gets over a good or bad start. Make gut health a priority and get your pigs on track for lifelong success.

To receive a recording of the webinar and learn more about Galloway’s strategies for good gut health, click the button below:

I would like more information on the Alltech^®Gut Health Management program.

The following is an edited transcript of Tom Martin’s interview with Dr. Kristen Brennan, a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky.

Click below to listen to the podcast:

                                    Dr. Kristen Brennan is a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky. In this interview with Tom Martin, Brennan helps us gain a better understanding of her field, nutrigenomics, and its role in sustainable agriculture.

Tom:                            What is the science of nutrigenomics?

Kristen:                        The easiest way to think about nutrigenomics is to break the word down into what it is: “nutri" and “genomics.” What we're aiming to study with nutrigenomics is how nutrition — whether that’s nutrients, forms of nutrients, diets, timing of diets — influences the animal's genome. So, we’re not changing the genome, but influencing the activity of all the genes of that animal’s genome.

Tom:                            Is this an outgrowth of the human genome project, or has it been around a lot longer than that?

Kristen:                        Nutrigenomics is something that's been around forever. From the time the first living organism evolved, it needed nutrients, and those nutrients had influence on the activity of the genes within that animal or cell. The thing that we've done within the last several years is to figure out how to capture that information. It's always been there, we just never had a way of measuring it before. Technologies like genome sequencing are the core foundation for measuring what we're seeing.

Tom:                            Is there a point in time when we realized that nutrients were having an impact on genetic expression?

Kristen:                        I think we’ve known for a long time the importance of nutrition. Centuries and centuries ago, they had an idea that nutrition had a vital role. I don't know if we knew at that point, really, what DNA was and what genes did, but we knew that nutrition could influence the outcome, or a phenotype of an animal — what we're seeing on the outside — and how important it was for good health.

Tom:                            What are the advantages of nutrigenomics in animal studies?

Kristen:                        What I think makes this field so exciting is that, first of all, when we’re dealing with actual sampling, we need a very small sample amount. We can do this with, for instance, a small draw of blood from an animal, or we can take a small biopsy. So, you're not having to euthanize an animal to get tissue.

                                       Even more of an advantage is the amount of information we get. If you think about most genomes, you're talking about thousands of genes. We can measure in a single snapshot how every one of those genes is behaving in response to a diet or nutrition. That is an amazing amount of information.

                                       The other advantage is that it can be really rapid. From the time we get a sample to the time we have an output of data, it can be as short as just a few days in the lab. So, a lot of information, small input and a ton (of data) in a very rapid way.

Tom:                            And are you able to understand why some animals respond differently than others to the very same nutrients?

Kristen:                        Yes. We can use this information to understand that. An example would be healthy versus diseased animals and why nutrition may play a role in how they respond to that illness. More and more, we're starting to understand how differences on a genetic level — different breeds of animals, different production states, things like that — can influence how that animal responds.

Tom:                            Are you able to dig down into it and figure out how nutrients and bioactive components in the food turn on or turn off certain genes?

Kristen:                        Yes. The biggest amount of information we get is just a simple “Do they or do they not turn genes on or off?” So, how does each individual gene activity respond to what you're feeding? As we’re understanding that more and more, we can take a step back and start to understand how they're doing it. They are what we call signaling pathways, which are like, if you set up a row of dominoes and you hit the first one, it sets everything off. It’s the same thing with gene activity. There is a series of molecules that are responsible for regulating or activating other ones. And we can start to decipher how we get from the nutrient that we’re feeding or the diet we're feeding to that endpoint, that last domino in the line.

Tom:                            You can actually target issues that call for some kind of nutritional intervention?

Kristen:                        Yes. And that's obviously one of the most exciting applications of this research. We can use this to define precision nutrition.

                                    One of the challenges with feeding animals, or people in general, is that there are so many environmental factors that influence how an animal responds to diet — things like illness and disease, but also production state, where they're living, what their basal diets are. And so, we can use this technology to get precise information on how we can use nutrition to get the best performance or best health out of that animal.

Tom:                            How do you carry out your research? What goes on in Kristen Brennan’s laboratory?

Kristen:                        It’s magic! This research is done in several steps. It’s really a team effort. The simplest study we have is between two groups of animals, and because so many things could influence gene expression, we want to make sure that those two groups of animals are as identical as possible — same breed, sex, age, production state, and they’re housed in similar environments. The only thing we want different between those two groups is the nutrient we’re interested in.

                                    For instance, if we’re looking at a form of a mineral like selenium, we might have one diet that contains selenium in the form of sodium selenite, and we might have the exact same diet for the other group that has selenium in the form of organic selenium like our Sel-Plex® product. Once we have fed these diets for a given amount of time — it just depends on what we're interested in looking at, what tissues and what nutrients we’re evaluating — then we obtain a sample. It can be as simple as just a very tiny muscle biopsy or a few milliliters of blood. We bring that to the lab, and our laboratory technicians will essentially take that tissue, rupture the cellular membranes and then the nuclear membranes and purify what we call the mRNA, or the transcripts, that are located within the nucleus. We make sure that transcript, or a total RNA, is of super high quality and purity because these assays are so precise. We have high standards for what we can use.

                                       And then we use a commercially available DNA microarray. And what that allows us to do is profile. It has probes for each gene on the animal's genome — for example in the case of a chicken, it has something like 18,000 probes — and that allows us to measure whether the mRNA, or the transcript, for each of those genes has been increased or decreased in response to the nutrient that we fed.

                                       At the end, we get a long spreadsheet that says gene A is increased, gene B unchanged, gene C is decreased.

                                       Then the tough part comes, and that is the data analysis. So, we have all of these data points — you’re talking about thousands — and it is sort of like taking one of those huge puzzles. If you took that box of puzzle pieces and threw it on the ground, you would just have a giant mess, right? When I get that Excel spreadsheet of thousands of rows and columns, that’s what it’s like, essentially. So, we need help to try to piece those puzzle pieces together. If we took one piece out, we might find a corner and that's really important. Just like if I look at that spreadsheet, I might find a gene that's very important, that's very highly increased or decreased. That's a starting point.

                                    What we really need to do to see the big picture is piece those puzzle pieces together. We use what we call bioinformatics — essentially biological statistics — and we use software programs that say, okay, these 100 genes are related, they all have a common biological function, and based on their activity, we predict that biological function to increase or decrease. And that helps us make sense of this information.

                                    So, just like piecing those puzzle pieces together, we get that big picture of what's going on inside an animal that results in what we're seeing on the outside like improved growth, or improved feed efficiency, or improved markers of health.

Tom:                            I'm under the impression that the “Holy Grail” for you would be to find and establish a link between nutritional genomics approaches and applied nutritional research. Can you explain?

Kristen:                        Sure. The ultimate goal, at least in my view, for nutrigenomics is when we do traditional nutrition studies, we take an experimental diet, we feed it to an animal and we look at a phenotypic output. So, what do we see in the whole animal? That might be body weight change, growth rates, feed efficiency — things we can measure in the whole cow or by just looking at the animal. We might look at blood markers, stuff like that. What often is lacking and what we can use nutrigenomics for is, how do we get from point A to point B? How do we get from feeding this diet to the response in the whole animal?

                                       What nutrigenomics gives us is a tool to look at a molecular reason for those changes. We can use nutrigenomics to figure out, are we affecting energy expenditure in the cell? Are we affecting protein translation in the muscle? Things like this can help us explain what we're seeing in that animal instead of just guessing on how something works.

Tom:                            Does this technology, nutrigenomics, reduce our reliance on large-scale animal studies, and is it less invasive than the traditional approach?

Kristen:                        I think so. When we do these studies, we can work with a much smaller number (of animals) per treatment. So, where you might need hundreds of animals to get, say, carcass quality measurements that are significant, we can use six or 10 animals per treatment and still get some of the same information that would explain why we see changes in a large animal. Obviously, they're complementary, but we use this technology to minimize the number of animals we need per treatment.

                                      The other advantage is the obtaining of samples. We don't need a whole kilo of skeletal muscle to do our analysis. We need a tiny amount. So, that really is noninvasive. We can use a simple blood draw that is noninvasive and get this information out of that.

Tom:                            The 21^st century farm is a changed place compared with that of the previous century. A big reason for that is the arrival of a lot of science, technology and big data. If we were to take your science, nutrigenomics, out of the laboratory and into the farm, how would producers use what you've learned?

Kristen:                        I think one of the major ways they can use it is precision nutrition — really formulating diets to meet the actual needs of an animal. And also to understand the form versus function of different nutrients. So, how do we get the best that we can get out of an animal through nutrition? Nutrigenomics gives us that tool to understand how.

Tom:                            To carry that further, beyond helping to determine what will work for an animal's genetic type, is nutrigenomics helping explain why we need to find what works for a given animal?

Kristen:                        Absolutely. And I think it really helps push the idea of precision behind nutrition. For so long, we've overfed nutrients. We haven't really paid attention to form versus function. Nutrigenomics is giving us reasons why form is so important in nutrients, and why precise levels are important. We're taking the guessing game out of animal nutrition.

                                       I think as our population grows and the need for food continues to increase, that really optimizing nutrition based on an animal’s genetic potential is going to be really, really important.

Tom:                            How can this genomic information help us better understand nutrition and nutrient science?

Kristen:                        That’s a great question. This gives us a good understanding of the hidden effects of nutrition — the things that we don't really understand; why we see the changes. Why are we seeing increased energy efficiency with different forms of selenium, for instance? If we just look at our traditional nutrition research, we have no idea. But we use nutrigenomics to say, “Okay, well, the genes that control, say, mitochondrial growth in the skeletal muscle in the animals are turned on by Sel-Plex, and that explains why we see changes in energy expenditure.”

                                       That’s the type of stuff that we can get through traditional animal nutrition research, and nutrigenomics really helps push that information ahead and gives us a better understanding of how nutrients function — things that we can't see by just looking at an animal.

Tom:                            One final question: Among the things that you're working on right now, what really interests you and excites you?

Kristen:                        Everything, as a true scientist! One of the areas that I'm completely fascinated by, and have been for years — and we've done quite a bit of work on it, but it's just something that I start to think about and almost gives me a headache — is the idea of nutritional programming. This is the concept of how early life nutrition — whether that's in a neonatal animal or even in the gestating diet, looking at offspring — how nutrition early in life influences an animal throughout its lifespan.

                                    We've done a lot of work to look at some of the things that happen, like gene expression changes that occur. When we change the diet of an animal in the first 96 hours of life, those patterns and the changes stay with that animal throughout its lifespan, and that completely fascinates me.

                                       I think that's an application that is something that can be applied through all different species of animals, whether that’s livestock or even humans. We think about how you are what you eat, but you're also what your mother ate and what her mother ate and then maybe what her dad ate. It starts to really fascinate you. So, that’s probably one the most exciting areas that we work on.

Tom:                            Dr. Kristen Brennan is a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky. Thank you for joining us.

Kristen:                        Thank you.

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