For Coppens International, which was welcomed into the Alltech family of companies on June 6, 2016, its 25th anniversary this month will be a celebration of past achievements as well as looking to the future. Now known as Alltech Coppens, we caught up with Patrick Charlton, CEO of Alltech Coppens, to find out more about this new development.

“It’s a very exciting time for me and the team here at Alltech Coppens,” notes Patrick. “The team welcomed me a little over two years ago, and I know more about fish these days than I thought I’d ever know!”

The company develops and produces a wide portfolio of specialist fish feed. Originally established 25 years ago as Coppens International, the company is recognized in particular for its high-quality starter feed for a broad range of fish species, including sturgeon, trout, catfish, eel, tilapia and carp. Exporting to more than 60 countries worldwide, Coppens International had been successful in its own right for many years, but as a relatively small operator, further growth and expansion was a challenge.

“Alltech provided the growth solution to Coppens International when we came together two years ago,” says Patrick. “Coppens offered Alltech a tremendous platform, and since 2016, we have been evolving the Alltech technologies within Coppens products to optimize the value of the feeds.

“In fact, I believe Alltech Coppens is the first feed nutrition company to replace all inorganic minerals thanks to our inclusion of Alltech’s Bioplex® range of chelated organic trace minerals into our feed,” he continues. “Our aim has always been to grow the Coppens business to become a part of Alltech’s global footprint and expand the brand by entering more markets and developing specialist feed for more fish species.”

This rebrand is a natural next step and one that aims to optimize on future growth opportunities, explains Patrick.

“Since the acquisition, our goal has been to establish Coppens International as the cornerstone of Alltech’s global aquaculture business. By becoming Alltech Coppens, we not only retain 25 years of history and reputation — we also move forward to ensure we are more relevant globally to our customers and the wider industry. Alltech Coppens is a solid platform on which we can grow our aqua nutrition business in the years to come.”

They say that if you stand still, you fail. That cannot be said of the team at Coppens.

“We have a very strong reputation in the market,” says Patrick. “This rebrand to Alltech Coppens is very much a natural progression. Since 2016, our teams have worked together, combining our respective specialist skills to deliver the very latest innovative aquaculture feeds directly to producers across the globe. This mission shall very much continue under the Alltech Coppens brand.”

Alltech Coppens reflects the company’s position as a global leader in nutritional solutions for aquaculture. The Alltech name strengthens relationships with global aquaculture customers. Alltech has invested heavily in Coppens during the past two years with the expansion of the Alltech Coppens Aqua Centre and the installation of a third extruder at the site. These investments were necessary not only to meet customer demands for more products and technology, but also to provide the team at Alltech Coppens increased production capacity. These investments have also allowed the team to expand into new markets such as Norway, the U.S., Bulgaria, Greece and Turkey as well as exciting collaboration work in Brazil.

“We have demonstrated our commitment to the aquaculture industry, and our customers can continue to expect further dedication now that we are Alltech Coppens,” says Patrick.

Headquartered in Helmond, the Netherlands, with a research center in Valkenswaard, the Netherlands, and production in Nettetal, Germany, this is indeed an exciting time for the Alltech Coppens team.

I would like to learn more about nutrition management strategies for aquaculture.

The following is an edited transcript of Tom Martin's interview with Dr. Anna Catharina Berge, veterinarian and owner of Berge Veterinary Consulting. Click below to hear the full interview:

Dr. Anna Catharina Berge, owner of Berge Veterinary Consulting BVBA, is a veterinarian with extensive knowledge and skills combining real-life animal husbandry with epidemiological perspectives of animal and public health challenges. Berge joins Tom Martin from Vosselaar, Belgium, to discuss the use of, and alternatives to, antibiotics in pig production.

Tom:                          Let’s begin with pig production. Is antimicrobial use in pig production a real threat?

Catharina:                 All antimicrobial use has the potential to increase antimicrobial resistance in bacteria. Antimicrobials are really vital to humans and animals to protect against bacteria that can cause disease or death. Antimicrobial resistance is threatening the efficacy of these valuable drugs to treat bacterial disease. Even the World Health Organization (WHO) stated in 2014 that the antimicrobial resistance situation is so serious that we are entering a post-antibiotic era in which common infections and minor injuries can kill. This is far from being an apocalyptic fantasy — it’s a very real possibility for the 21^st century. This is not just some journalists writing up some fearful scenario. This was the WHO. So, it is a real threat.

                                 Microbial resistance in pig production is usually a consequence of decades of antibiotic use for disease prophylaxis or growth promotion. The antibiotics administered are not completely absorbed by the animals. If you’re giving an antibiotic to an animal, 30 to 90 percent of those antibiotics are actually excreted through the urine or feces. The antibiotics can reach the source through medical waste, improper drugs or even from dust from pens in barns. These antibiotic residues can also impact the environment and disturb the delicate ecological balance.

                                 Antibiotic-resistant bacteria may also spread into a virus through other mechanisms. Antibiotic-resistant bacteria may also spread to humans through food or through the environment. These antibiotic-resistant bacteria don't just disappear if we stop using antibiotics. They tend to linger. They’re easily created, but they don't tend to disappear quickly. Therefore, we need to do everything to not increase this pool of resistant disease that can spread between different types of bacteria. These resistant diseases can spread from bacteria that are not dangerous and just hanging around in our dust to those bacteria that are really causing disease and even death. If that resistant disease finds bacteria that cause death, then we have a bacterial disease that can’t be treated, and we may die from it. So, resistance is dangerous.

                                 Antibiotic resistance is also an increasing challenge on many pig farms because producers are noticing that good old antibiotics are not working any longer because bacteria become resistant to them. So, they use newer and newer antibiotics. And this newer antibiotic is what the WHO now calls critical antibiotics, those that we want to maintain to treat humans against dangerous disease, so we’re building up resistance to all of these newer antibiotics. The problem is, there are really no new antibiotics created today. The pharmaceutical industry has stopped investing in the research and development of new antibiotic drugs, so we're running out of good drugs to treat bacteria.

Tom:                          You have noted that herd-level immunity, individual pig gut health, systemic immunity, nutritional status, stress levels, and environmental conditions all interact. Why is it important to understand these interactions?

Catharina:                 No animal, organ or cell works in isolation. They all work closely together and, hopefully, in harmony. They all influence each other. So, a pig, furthermore, is living within a very complex production system where you have various factors that can influence its health and productivity. So, unless you take the whole system into account and evaluate this whole system, you don't really know the cost of a disease or why the pig is not doing well. You may think the cause is something other than disease, but it’s really the disease as a consequence of the production system.

                                    Our production systems have not been optimized for what the pig needs and what we want from the pig. We are trying to adapt the pig to our production systems instead of adapting our systems to the pig. This is creating a problem, and one of the solutions has been to medicate with antibiotics.

Tom:                          What challenges do antibiotics pose to the gut health of pigs and livestock?

Catharina:                 Antibiotics can prevent bacteria from reproducing or destroy bacteria. These antibiotics don't differentiate between bacteria that are good for the body and those that are potentially harmful. Some antibiotics work on different threats to the bacteria and some can work against a lot of bacteria types. Others work against just a few.

                                 Many of these antibiotics are used in the feed in pig production for extended periods of time. They have what we call a broad spectrum. They work against a lot of different bacteria. An example of such is tetracycline. These antibiotics can modify the gut flora and reduce diversity of the bacteria in the gut. Therefore, many good bacteria that are helping in many different ways are killed. Some harmful bacterial also are killed, but when the good gut flora is destroyed, then the pathogenic, harmful bacteria have a bigger chance to reproduce and attack the intestinal lining, maybe even invade the body and cause disease. It’s really essential to create a good microbial flora in the pig, and these antibiotics can actually work against them in that way.

Tom:                          Globally, farmers are now showing that it is possible to reduce antimicrobial use without sacrificing performance in health. A key focus has been placed on gut health. Why is gut and intestinal health in pigs so important?

Catharina:                 It’s key to a healthy animal. The gut is responsible for the digestion and absorption of nutrients that are necessary for the whole body to function properly. Through the food ingested, the pig gets energy — macronutrients and micronutrients — to fuel and support the functions of every single cell in the body. So, if the gut is not working, then the pig’s overall health will suffer.

                                  It’s in the gut that the immune system encounters many potential pathogens that are harmful bacteria. These need to be stopped before they start destroying the intestinal linings or invade the body. In the gut, we have the most immune cells of the whole body. This immunity has high requirements for energy and nutrients and must be in top shape for protecting the pig. If you don't have good gut health, then the immune system doesn't have enough energy to do good work.

                                 A healthy gut, furthermore, has a microflora of bacteria that participates in the digestion of many nutrients. These healthy gut microflora also prevent pathogens from growing and invading intestinal cells. This microflora shows a high level of diversity, and every bacteria species influence each other. So, the healthy gut microflora is also critical to a healthy gut.

Tom:                          What do you think will be the best measures to reduce antibiotic use?

Catharina:                 I like the holistic approach. The best measure to decrease antibiotic use is to optimize the production system and nutrition to better meet the pig’s basic needs.

                                 A first step is to create awareness of the consequences of our antibiotic medicating system and motivate people to change. It’s important for producers to understand that reductions in antibiotic use can be made without compromising the health of the animal or their productivity. But it requires an evaluation of the whole production system and nutrition to identify the weaknesses in every single system because every single system we enter is different.

                                 The easiest part to change is nutrition for the pig and making sure that it’s correct for every single stage of its life and that the pig is not exposed to high levels of bacteria or mycotoxins in the feed and the water. Thereafter, we are starting to look at management changes and housing changes to meet the physiological needs of the animals and protect them from disease from inside and outside the unit. That’s also called “biosecurity,” and that's very important. Thereafter, we need to start looking at how we can boost immunity so that the pig is then able to meet all the challenges.

Tom:                          Among the farms you are working with, what percentage of reduction do you think is realistically achievable?

Catharina:                 I would say most farmers across the world are still using a lot of antibiotics prophylactically to prevent disease, or they use it for growth promotion. And I believe that all of that use can stop. There, again, there has to be a motivation of the producer to change. But, in general, if we go onto a farm, a realistic goal we usually can see without too much of a challenge is a 50 percent reduction in antimicrobial use already within the first year.

Tom:                          What are the components that should be included in any antibiotic reduction program?

Catharina:                 There was a philosopher in 1850 that said if you don't record it, you can’t improve it. So, you have to have an antibiotic use registration system and you have to evaluate it. It’s not enough just to jot down a few notes in a book somewhere. You have to evaluate. Then you have to set targets. You have to ask, “How can I achieve this reduction with those targets?” You need to look at the appropriate nutrition for every single stage of production. All the pigs, based upon where they are and how old they are, have different needs. You need to have appropriate nutrition. You also have to have very good, quality feeds — low microbial levels and low mycotoxin levels. Then you need to look at the management level. How are you moving the pigs around the system? Are you weaning them too young? Are you stressing them at different phases by mixing litters, and so on? So, management systems are very important.

                                 Housing systems need to be evaluated. Many times, we have pigs in old systems where it’s really not optimized for holding them, and we may need to consider rebuilding on a long-term scale.

                                 A very important part is biosecurity. Biosecurity is what we call “disease protection.” You need to protect the animals from disease that is found inside the uterus. That’s called “internal biosecurity.” You also need to protect the pigs from diseases that are not on the farm currently, but could be introduced by animals, vehicles and people. That’s called “external biosecurity,” and that's very important.

                                  You also need to be able to correctly diagnose and treat the clinical diseases in the best way. People don’t always understand what they're seeing and how it should be best treated.

                                 And of course, we have the alternatives to antibiotics that are valuable tools to support health and productivity. We have products that can support microflora in the gut and optimize the strength of the gut lining such as Bio-Mos® and Actigen®.

                                 We have alternatives to boost immunity. Vaccines, for example, are vital to protect the pigs against many diseases. Organic minerals are important to boost the immune system and help the immune system work optimally. So, all of those components are appropriate and are very important to consider in a program.

Tom:                          You have suggested that the goal to reduce antibiotic use should be rephrased to a goal to produce healthy production systems. How do producers look at this challenge as an opportunity instead of a threat?

Catharina:                 Well, I think for that exact reason: Health is not a threat. It’s something we all strive for, whether in our bodies, a healthy business, healthy ecosystem or healthy planet. And producers are realizing more and more that diseases are costly. Furthermore, there is no joy in working with sick animals. Honestly, I have yet to meet a pig producer that tells me that he or she wants to use antibiotics. It’s rather that they believe it's necessary to prevent disease. When we start showing that we can remove the antibiotics without suffering productivity losses or increased diseases, then they start seeing the possibility of moving toward a more sustainable production.

Tom:                          Can you expand on the practical measures a pig operation could implement to develop a healthy production system?

Catharina:                 I would recommend any pig producer that wants to develop a healthy production system seek out a team of experts: consultants, nutritionists and veterinarians who can evaluate the whole system. That is what we call a “whole herd audit.” This audit usually takes at least a day. Based upon this initial audit, there will be various points to address, whether in housing, management, nutrition or disease treatment. You start setting up the concrete plan of what major issues to address and what targets to achieve.

                                  Everyone involved in production, as well as nutritionists and veterinarians, needs to be involved in an antimicrobial reduction plan. Once you’ve set up this plan and you start implementing, it's really important that you have a very good follow-up. Therefore, you should have regular audits to monitor the progress, create accountability for effort and set up new achievable targets as necessary. Alltech has actually developed such a holistic antimicrobial reduction audit.

Tom:                          What is the future of antibiotic use in the pig industry?

Catharina:                 I hope that the pig industry will move toward reducing antibiotics very quickly so that the consumers are not forcing them to completely ban all antibiotics. The future of antibiotic use, as I see it, is that antibiotics will be available for individual treatment of sick pigs or serve a metaphylactic use in the exceptional cases. But all prophylaxis or regular continual use such as growth promotion is stopped.

Tom:                          In the past couple of years, we've seen some significant increases in the presence of mycotoxins in haylage, barlage and silage. Why are mycotoxins important to consider when we're talking about antibiotic reduction?

Catharina:                 Mycotoxins are produced in various unfavorable conditions. As you mentioned, we see them more and more emergent in all our feed sources. They’re very toxic compounds, and they can impact both immunity and health. There are various types of mycotoxins present in most feeds in various levels. We have seen in audits of many pig producers that an underlying reason for poor health and productivity is a high level of mycotoxin exposure.

Tom:                          What kind of effects do mycotoxins have on pigs?

Catharina:                 That is one of the problems — that people don't realize that they have a mycotoxin challenge in their production because the signs are very subtle and diffused. There are various symptoms that the producer does not recognize. Some of these symptoms are, for example, poor feed efficiency, suboptimal growth, digestive distress, various disease problems and poor reproductive performance. Mycotoxins have strong immune suppressors, and that’s one of the reasons why we see more and more disease and why the pigs are susceptible to disease.

                                 All of these mycotoxins — there are many — have different modes of action. But there’s seldom just one mycotoxin present in the feed. There’s usually multiple. When they’re working together, sometimes they can have an additive effect, but sometimes they will have a multiplicative effect. The gut and immune system are first to encounter the mycotoxins once ingested. We have talked about the importance of gut health and antimicrobial reduction audits and programs. It’s essential to address this risk as an aspect of the reduction program. We have always seen in our antimicrobial reduction audits that when we go in and address these mycotoxin challenges and feed through the inclusion of a good broad-spectrum mycotoxin binder such as Mycosorb®, then we see improved productivity.

Tom:                          What consumer demands are driving significant changes in the industry?

Catharina:                 Consumers have high demands on the industry. Today’s consumers want food from animals from a sustainable, animal-friendly system. They also want food from animals that have not been medicated with antibiotics. We have seen that consumers are actually willing to pay a higher price for meat produced without antibiotics.

                                  Animal welfare is another area that has a very high importance for consumers. Measures such as tail docking and castration are increasingly questioned. Since these interventions are often coupled with an antibiotic injection, systems where castration and tail docking are not necessary will have reduced antimicrobial use. Tail docking has been performed to reduce the incidence of tail biting in group-housed pigs. If the animal environment is improved, it is possible to rear pigs with their tails intact. That is the case in Sweden, where tail docking is banned.

                                  An improved group housing system will reduce antimicrobial use in growing pigs. Another area is the group housing for gestating sows, so they don’t stand locked up in small crates all their life. This is also highly desirable by consumers. This also optimizes the health and strength of these sows, and they can rear healthier piglets. The animal welfare requests of consumers contribute to healthy animals that do not need antibiotics. 

Tom:                          Dr. Cat Berge of Berge Veterinary Consulting BVBA in Vosselaar, Belgium. Thank you so much for joining us.

Have a question or comment?

[DUNBOYNE, Ireland] – Alltech’s European Bioscience Centre, located in Dunboyne, County Meath, has been nominated for a US-Ireland Research Innovation Award. The centre has been nominated in the Multinational Corporation Category for research on how reduced diversity among intestinal gut microbes can affect animal health and can lead to the overgrowth of pathogens and the development of resistance. It also examines how increasing gut microbial diversity through nutrition and diet can aid in the control of these issues with the aim of reducing reliance on antibiotics.

Now in its fourth year, the awards are a joint initiative between the Royal Irish Academy and the American Chamber of Commerce Ireland and are aimed at recognising excellence in research innovation, creation and invention by an organisation as a result of U.S. foreign direct investment in Ireland. The winners will be announced on 18 May at the Chamber’s annual dinner, which will also welcome Minister for Business, Enterprise and Innovation Heather Humphreys.

Dr. Richard Murphy, research director at the Alltech European Bioscience Centre, said the nomination was a fantastic achievement for the research team.

“At Alltech, we strive for success,” said Murphy. “Our innovative solutions and cutting-edge technologies deliver real results for our customers and farmers, and so this award is a tremendous achievement for us as a research team. We are delighted to be nominated for a US-Ireland Research Innovation Award. This is a true testament to the hard work our team in Dunboyne put into researching innovative farming solutions.”

Alltech Ireland has long been a leader in both the Irish and European agriculture industry. Located in Dunboyne, County Meath, it became the first Alltech office to be established in mainland Europe in 1981 and today serves as Alltech’s European headquarters and bioscience centre.

Alltech’s European Bioscience Centre is Alltech’s pivotal research centre in Europe. The research work carried out at the centre specialises in cellular biotechnology, and the team of 20 scientists based in Dunboyne have developed unique insights into specific focus areas such as yeast cell wall architecture, trace element chelation, biomarker detection and microbial population dynamics. This work has resulted in the development of new solutions, services and analytical tools that improve producer profitability and efficiency.

“We have approximately 20 full-time scientists on-site in Dunboyne,” said Murphy. “We are very proud of our highly educated team and close links with Irish universities. The majority of the team have earned their Ph.D. or master’s degree with Alltech.

“Since redevelopment work on the facility was completed in 2013, the team at Alltech are very lucky to work in labs of exceptional quality and standard, thanks to Mrs. Deirdre Lyons, Alltech’s director of corporate image and design, who is responsible for designing our labs,” he continued. “This enables us to provide a state-of-the-art platform that enables young scientists to work with Alltech's expert team of biochemists, microbiologists and nutritionists.” 

Alltech’s European Bioscience Centre is one of the company’s three major bioscience centres around the world, with each centre having its own innovative focus. The centres are complemented by more than 20 research alliances with leading universities around the world. Alltech’s research team are also responsible for over 500 patents awarded to Alltech globally.

The following is an edited transcript of Tom Martin’s interview with Dr. Kristen Brennan, a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky.

Click below to listen to the podcast:

                                    Dr. Kristen Brennan is a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky. In this interview with Tom Martin, Brennan helps us gain a better understanding of her field, nutrigenomics, and its role in sustainable agriculture.

Tom:                            What is the science of nutrigenomics?

Kristen:                        The easiest way to think about nutrigenomics is to break the word down into what it is: “nutri" and “genomics.” What we're aiming to study with nutrigenomics is how nutrition — whether that’s nutrients, forms of nutrients, diets, timing of diets — influences the animal's genome. So, we’re not changing the genome, but influencing the activity of all the genes of that animal’s genome.

Tom:                            Is this an outgrowth of the human genome project, or has it been around a lot longer than that?

Kristen:                        Nutrigenomics is something that's been around forever. From the time the first living organism evolved, it needed nutrients, and those nutrients had influence on the activity of the genes within that animal or cell. The thing that we've done within the last several years is to figure out how to capture that information. It's always been there, we just never had a way of measuring it before. Technologies like genome sequencing are the core foundation for measuring what we're seeing.

Tom:                            Is there a point in time when we realized that nutrients were having an impact on genetic expression?

Kristen:                        I think we’ve known for a long time the importance of nutrition. Centuries and centuries ago, they had an idea that nutrition had a vital role. I don't know if we knew at that point, really, what DNA was and what genes did, but we knew that nutrition could influence the outcome, or a phenotype of an animal — what we're seeing on the outside — and how important it was for good health.

Tom:                            What are the advantages of nutrigenomics in animal studies?

Kristen:                        What I think makes this field so exciting is that, first of all, when we’re dealing with actual sampling, we need a very small sample amount. We can do this with, for instance, a small draw of blood from an animal, or we can take a small biopsy. So, you're not having to euthanize an animal to get tissue.

                                       Even more of an advantage is the amount of information we get. If you think about most genomes, you're talking about thousands of genes. We can measure in a single snapshot how every one of those genes is behaving in response to a diet or nutrition. That is an amazing amount of information.

                                       The other advantage is that it can be really rapid. From the time we get a sample to the time we have an output of data, it can be as short as just a few days in the lab. So, a lot of information, small input and a ton (of data) in a very rapid way.

Tom:                            And are you able to understand why some animals respond differently than others to the very same nutrients?

Kristen:                        Yes. We can use this information to understand that. An example would be healthy versus diseased animals and why nutrition may play a role in how they respond to that illness. More and more, we're starting to understand how differences on a genetic level — different breeds of animals, different production states, things like that — can influence how that animal responds.

Tom:                            Are you able to dig down into it and figure out how nutrients and bioactive components in the food turn on or turn off certain genes?

Kristen:                        Yes. The biggest amount of information we get is just a simple “Do they or do they not turn genes on or off?” So, how does each individual gene activity respond to what you're feeding? As we’re understanding that more and more, we can take a step back and start to understand how they're doing it. They are what we call signaling pathways, which are like, if you set up a row of dominoes and you hit the first one, it sets everything off. It’s the same thing with gene activity. There is a series of molecules that are responsible for regulating or activating other ones. And we can start to decipher how we get from the nutrient that we’re feeding or the diet we're feeding to that endpoint, that last domino in the line.

Tom:                            You can actually target issues that call for some kind of nutritional intervention?

Kristen:                        Yes. And that's obviously one of the most exciting applications of this research. We can use this to define precision nutrition.

                                    One of the challenges with feeding animals, or people in general, is that there are so many environmental factors that influence how an animal responds to diet — things like illness and disease, but also production state, where they're living, what their basal diets are. And so, we can use this technology to get precise information on how we can use nutrition to get the best performance or best health out of that animal.

Tom:                            How do you carry out your research? What goes on in Kristen Brennan’s laboratory?

Kristen:                        It’s magic! This research is done in several steps. It’s really a team effort. The simplest study we have is between two groups of animals, and because so many things could influence gene expression, we want to make sure that those two groups of animals are as identical as possible — same breed, sex, age, production state, and they’re housed in similar environments. The only thing we want different between those two groups is the nutrient we’re interested in.

                                    For instance, if we’re looking at a form of a mineral like selenium, we might have one diet that contains selenium in the form of sodium selenite, and we might have the exact same diet for the other group that has selenium in the form of organic selenium like our Sel-Plex® product. Once we have fed these diets for a given amount of time — it just depends on what we're interested in looking at, what tissues and what nutrients we’re evaluating — then we obtain a sample. It can be as simple as just a very tiny muscle biopsy or a few milliliters of blood. We bring that to the lab, and our laboratory technicians will essentially take that tissue, rupture the cellular membranes and then the nuclear membranes and purify what we call the mRNA, or the transcripts, that are located within the nucleus. We make sure that transcript, or a total RNA, is of super high quality and purity because these assays are so precise. We have high standards for what we can use.

                                       And then we use a commercially available DNA microarray. And what that allows us to do is profile. It has probes for each gene on the animal's genome — for example in the case of a chicken, it has something like 18,000 probes — and that allows us to measure whether the mRNA, or the transcript, for each of those genes has been increased or decreased in response to the nutrient that we fed.

                                       At the end, we get a long spreadsheet that says gene A is increased, gene B unchanged, gene C is decreased.

                                       Then the tough part comes, and that is the data analysis. So, we have all of these data points — you’re talking about thousands — and it is sort of like taking one of those huge puzzles. If you took that box of puzzle pieces and threw it on the ground, you would just have a giant mess, right? When I get that Excel spreadsheet of thousands of rows and columns, that’s what it’s like, essentially. So, we need help to try to piece those puzzle pieces together. If we took one piece out, we might find a corner and that's really important. Just like if I look at that spreadsheet, I might find a gene that's very important, that's very highly increased or decreased. That's a starting point.

                                    What we really need to do to see the big picture is piece those puzzle pieces together. We use what we call bioinformatics — essentially biological statistics — and we use software programs that say, okay, these 100 genes are related, they all have a common biological function, and based on their activity, we predict that biological function to increase or decrease. And that helps us make sense of this information.

                                    So, just like piecing those puzzle pieces together, we get that big picture of what's going on inside an animal that results in what we're seeing on the outside like improved growth, or improved feed efficiency, or improved markers of health.

Tom:                            I'm under the impression that the “Holy Grail” for you would be to find and establish a link between nutritional genomics approaches and applied nutritional research. Can you explain?

Kristen:                        Sure. The ultimate goal, at least in my view, for nutrigenomics is when we do traditional nutrition studies, we take an experimental diet, we feed it to an animal and we look at a phenotypic output. So, what do we see in the whole animal? That might be body weight change, growth rates, feed efficiency — things we can measure in the whole cow or by just looking at the animal. We might look at blood markers, stuff like that. What often is lacking and what we can use nutrigenomics for is, how do we get from point A to point B? How do we get from feeding this diet to the response in the whole animal?

                                       What nutrigenomics gives us is a tool to look at a molecular reason for those changes. We can use nutrigenomics to figure out, are we affecting energy expenditure in the cell? Are we affecting protein translation in the muscle? Things like this can help us explain what we're seeing in that animal instead of just guessing on how something works.

Tom:                            Does this technology, nutrigenomics, reduce our reliance on large-scale animal studies, and is it less invasive than the traditional approach?

Kristen:                        I think so. When we do these studies, we can work with a much smaller number (of animals) per treatment. So, where you might need hundreds of animals to get, say, carcass quality measurements that are significant, we can use six or 10 animals per treatment and still get some of the same information that would explain why we see changes in a large animal. Obviously, they're complementary, but we use this technology to minimize the number of animals we need per treatment.

                                      The other advantage is the obtaining of samples. We don't need a whole kilo of skeletal muscle to do our analysis. We need a tiny amount. So, that really is noninvasive. We can use a simple blood draw that is noninvasive and get this information out of that.

Tom:                            The 21^st century farm is a changed place compared with that of the previous century. A big reason for that is the arrival of a lot of science, technology and big data. If we were to take your science, nutrigenomics, out of the laboratory and into the farm, how would producers use what you've learned?

Kristen:                        I think one of the major ways they can use it is precision nutrition — really formulating diets to meet the actual needs of an animal. And also to understand the form versus function of different nutrients. So, how do we get the best that we can get out of an animal through nutrition? Nutrigenomics gives us that tool to understand how.

Tom:                            To carry that further, beyond helping to determine what will work for an animal's genetic type, is nutrigenomics helping explain why we need to find what works for a given animal?

Kristen:                        Absolutely. And I think it really helps push the idea of precision behind nutrition. For so long, we've overfed nutrients. We haven't really paid attention to form versus function. Nutrigenomics is giving us reasons why form is so important in nutrients, and why precise levels are important. We're taking the guessing game out of animal nutrition.

                                       I think as our population grows and the need for food continues to increase, that really optimizing nutrition based on an animal’s genetic potential is going to be really, really important.

Tom:                            How can this genomic information help us better understand nutrition and nutrient science?

Kristen:                        That’s a great question. This gives us a good understanding of the hidden effects of nutrition — the things that we don't really understand; why we see the changes. Why are we seeing increased energy efficiency with different forms of selenium, for instance? If we just look at our traditional nutrition research, we have no idea. But we use nutrigenomics to say, “Okay, well, the genes that control, say, mitochondrial growth in the skeletal muscle in the animals are turned on by Sel-Plex, and that explains why we see changes in energy expenditure.”

                                       That’s the type of stuff that we can get through traditional animal nutrition research, and nutrigenomics really helps push that information ahead and gives us a better understanding of how nutrients function — things that we can't see by just looking at an animal.

Tom:                            One final question: Among the things that you're working on right now, what really interests you and excites you?

Kristen:                        Everything, as a true scientist! One of the areas that I'm completely fascinated by, and have been for years — and we've done quite a bit of work on it, but it's just something that I start to think about and almost gives me a headache — is the idea of nutritional programming. This is the concept of how early life nutrition — whether that's in a neonatal animal or even in the gestating diet, looking at offspring — how nutrition early in life influences an animal throughout its lifespan.

                                    We've done a lot of work to look at some of the things that happen, like gene expression changes that occur. When we change the diet of an animal in the first 96 hours of life, those patterns and the changes stay with that animal throughout its lifespan, and that completely fascinates me.

                                       I think that's an application that is something that can be applied through all different species of animals, whether that’s livestock or even humans. We think about how you are what you eat, but you're also what your mother ate and what her mother ate and then maybe what her dad ate. It starts to really fascinate you. So, that’s probably one the most exciting areas that we work on.

Tom:                            Dr. Kristen Brennan is a research project manager at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition in Nicholasville, Kentucky. Thank you for joining us.

Kristen:                        Thank you.

Looking for more information on the science and business of agriculture? Click here. 

“You are what you eat” might strike you with a bit of fear or guilt depending on what it is that you are munching at the moment. While the origins of this phrase are probably as old as mankind, fundamental research now supports the importance of eating the right things, at the right time, both in humans and animals. 

Our genes are the blueprint that defines who we are. How genes express themselves in the presence of nutrition, to produce proteins, is called “gene expression.” The science that defines how we understand this interplay between what we eat and how our genes function is called “nutrigenomics.”

A small chip, representing all the genes in the tissue of the individual being examined, allows scientists to predict precisely what effects to expect from dietary changes by showing which genes are activated and deactivated (in other words, turned “on” or “off”).

Just over ten years ago, Alltech opened a first-of-its-kind facility dedicated to the study of animal nutrition’s impact on gene expression. This study of nutrigenomics has allowed scientists to determine what outcomes to expect from feeding specific foods, feeds and dietary supplements to animals without waiting the months or even years that are typical in traditional farm trials. Additionally, nutrigenomics is minimally invasive research, requiring little from animals, such as minor bloodwork tests.

Over the 10 years since the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition opened, nutrigenomics has been used to:

• Understand how specific foods and diet structures change gene expression.
• Quickly screen and identify new nutrients with similar benefits to existing elements of the modern livestock diet.
• Predict responses to novel nutrients or foods.

10 Nutrigenomics Breakthroughs

1. Truly Amaize-ing

Although considered “amazing” by some farmers who use it, Amaize® from Alltech was a product with an elusive mode of action.

Cattle and other ruminants rely upon their first stomach (the rumen) to break down fiber. Enzymes such as Amaize should help with this digestion process. Using traditional techniques, researchers demonstrated that adding Amaize resulted in carcass weight gain for beef and greater milk production in dairy.

Examining tissue samples using gene expression, however, added much more to the story. The enzyme’s impact on the animal’s metabolic system showed that Amaize optimizes animal growth.

Several key changes were noted in particular. Genes relating to the expression of insulin-like growth factor (IGF-1), insulin receptors and the growth hormone were affected positively. These genes all have a direct correlation to increasing metabolic activity and therefore body growth.

Nutrigenomics allowed scientists to precisely understand the true function of Amaize, making it possible to issue specific recommendations to farmers of how and how much to incorporate into their cattle’s diets to maximize production and profitability (primary scientist: Dr. Ronan Power, Alltech). 

2. EconomasE: An economical alternative to vitamin E

In essence, EconomasE is an antioxidant supplement, demonstrating similar biological functions to vitamin E, but more economically.

Vitamin E is known throughout the world for its powerful antioxidant properties. Antioxidants inhibit the oxidation of other molecules, which can produce free radicals. Free radicals, unpaired loose electrons, cause damage to cells in the body. Generally, therefore, a person who consumes antioxidants will be healthier and in better shape to fight off illness, which is why doctors advise eating antioxidant-rich foods like leafy greens, nuts and certain berries.

Humans aren’t the only ones to benefit from antioxidants; all animals do, and this is why vitamin E is routinely included in the diets of all production animals. Vitamin E, however, is very expensive, and producers often seek ways to minimize its inclusion in their feed. The caveat is that reduction of vitamin E can increase the likelihood of requirement for antibiotics.

Using nutrigenomics, researchers were able to identify vitamin E’s mode of action and then set about identifying other compounds or combinations with similar effects. EconomasE proved capable of replicating the gene expression changes seen with vitamin E, and this was confirmed in 46 subsequent trials with poultry, swine and cattle. EconomasE maintained meat quality and the beneficial, protective antioxidative effects of vitamin E without the high price tag (primary scientist: Dr. Karl Dawson, Alltech).

3. Using zinc to facilitate development

Zinc is a trace mineral required by all animals to grow and develop properly. It supports immune function, allowing the animal to overcome immune challenges. In animals, through optimizing the immune response, it reduces risks associated with a severe infection known as necrotic enteritis (NE), which costs the poultry industry alone an estimated $5 to $6 billion globally and has mortality rates of up to 1 percent per day.

Necrotic enteritis is caused by the pathogenic bacteria family of Clostridium perfringens, resulting in lesions of the intestine that inhibit the absorption of nutrients, further weakening the sick animal and sometimes leading to death. In the last few years, scientists have been searching for ways to reduce the effects of necrotic enteritis in production animals such as poultry, pigs and cattle.

Nutrigenomics also confirmed that the form of zinc used is important. Forms such as zinc oxide and zinc sulphate that are typically used in animal diets, and in human supplements, are less effective than those connected to mixed peptides, which impact how the zinc is absorbed. Treating the animal in a holistic manner, supplying it with nutrients in the optimal form, enables that animal to be far better prepared to fight off potential infection, resulting in less antibiotic use and better efficiency of food digestion, both of which will save poultry producers (and consumers) billions of dollars annually (primary scientist: Dr. Daniel Graugnard, Alltech).

4. Mitigating myopathies in meat

As recently as five years ago, a condition known as “woody breast” wasn’t even on chicken producers’ list of concerns. Now, it is credited with losses conservatively estimated at $200 million dollars in the U.S. and affects chicken producers in Brazil, Spain and Italy, amongst others. An affliction of the chicken breast, it results in tough, chewy and otherwise inedible meat.

While genetics certainly play a factor, woody breast is generally considered to be directly correlated to how fast producers grow their chickens. Consider that in 1930, the average chicken was slaughtered at 2.5 pounds (1.1 kilograms) and took 50 days to gain each pound of weight. Less than 100 years later, we grow chicken to 6 to 8 pounds live weight, and they can put on a pound every eight days!

At a scientific level, fast-growing chickens are being affected by hypoxia (low blood), increased oxidative stress, inflammation and an increase in fibrofatty tissue.  From a consumer perspective, this results in chewy chicken and a generally unpleasant eating experience. However, understanding gene expression changes through nutrigenomics has enabled the development of a feed program that decreases the oxidative effects within the bird, resulting in normal tasting breast fillets for consumers (primary scientist: Dr. Rebecca Delles, Alltech).

5. Actigen: A stronger next generation of a proven success

For many years, Bio-Mos® has been a star ingredient in animal feed. It supported animal performance naturally by reinforcing the function of the digestion system and enhancing feed efficiency.   

The challenge was that the nature of natural is variation: color, odor and particle size relating to the natural process of production. Producers wanted the benefits of Bio-Mos, but they wanted it to be more concentrated, make it more economical and make it traceable.  

Nutrigenomic research quickly confirmed Actigen®’s similarities to Bio-Mos but also showed it to be 2.5 to five times more powerful.

Subsequent animal feeding trials later proved Actigen’s ability to help animals achieve their genetic potential. However, nutrigenomics confirmed its biological value much earlier, in a matter of weeks rather than months or years (primary scientist: Dr. Colm Moran, Alltech).

6. You are what your mother ate: The science of epigenetics

Epigenetics, or how an environment impacts the expression of inherited genes, is the next science that we expect will revolutionize the way we think of nutrition. In this case, what the parents ate, and what the parents of their parents ate, affects gene expression. And, it goes beyond nutrition. Studies have shown that overeating, undereating, exercise and smoking all have potential benefits or deleterious effects on future generations.

Pregnant sows at the world’s largest pig farm were fed Actigen during the last trimester and demonstrated epigenetic benefits. Tissue samples from their offspring exhibited gene expression changes suggesting stronger immune systems and enhanced nutrient uptake. So, as epigenetics suggests, feeding the mothers Actigen resulted in pigs that were much better off than those whose mothers did not receive it.

Healthier piglets will grow better, be more efficient, have stronger immune systems and less likelihood of disease infections/need for antibiotics (primary scientist: Dr. Kristen Brennan, Alltech).

7. Programmed nutrition: Conditioning gene expression

Within the lifetime of a person or animal, genes can be conditioned. In other words, we can design specific feeding regimes that prime the genes so that when a second diet is introduced, those genes express in ways that are more beneficial for the animal. This can be especially of benefit in the cattle industry, where cattle are bred and born in one location and often exchange hands three or four times.

Programmed nutrition shows that when newborn animals are fed supplements at specific levels and specific times, their bodies can better learn to utilize and retain these nutrients. As the animal grows, they become more efficient and require fewer nutrients than animals receiving excess supplements.

One example is EPNIX®. Part of a feeding program designed for genetic conditioning, the timing of feeding EPNIX to cattle is critical. It is a two-part process: the first part conditions the animal’s body to utilize nutrients better and the second part involves feeding the optimal nutrients.

EPNIX is a natural feed program that can positively improve cattle performance, meat quality and even reduce the environmental impact of beef farming (primary scientist: Dr. Vaughn Holder, Alltech).

Check out this podcast by Alltech research scientist Dr. Vaughn Holder to learn more about EPNIX.

8. In ovo feeding: Feed the egg before the chicken

Typically, the time from when an egg is laid to when it hatches is 21 days, almost the same amount of time it takes the chicken to grow. So it’s not surprising that poultry producers are increasingly wondering what nutrition a chick receives inside the egg.

Using nutrigenomics, scientists can look at what happens when different nutrients are introduced into the eggs. When used correctly, in ovo (Latin for “inside the egg”) feeding methods can be a powerful way to improve the development and health of the animal.

Careful egg injections of tiny doses of water-soluble sugar called MR8, from a probiotic yeast, resulted in baby chicks with stronger immune systems at birth and more efficient digestive systems. Not only that, but their hatchability increased, with more chicks born and improved survivability in the first week. Additionally, nutrigenomics showed a more developed digestive system physiologically and structurally, giving the bird a strong head start when compared to chicks that didn’t get the sugar from the probiotic yeast.

Today, implementing in ovo feeding requires special machines for use in hatcheries incubating thousands of eggs. However, the technology is quickly emerging to make in ovo feeding a strong part of poultry nutrition’s future (primary scientist: Dr. Rijin Xiao, Alltech).

 9. Serving salmon sans sea lice

Fish have never been more popular with consumers. As such, fish farming, or aquaculture, has become very important. In fact, more fish now come from farms than are caught in the sea. Yet, aquaculture presents its own challenges, including managing diseases and parasites. Sea lice alone cost the aquaculture industry an estimated $1 billion dollars a year. The threat of sea lice to salmon is not new, and salmon have developed their own protection by the secretion of a mucous layer encompassing its scales. This works, but when the sea lice are big enough, they can harm the fish and sometimes even kill it.

Until now, no annotated gene chip for salmon existed. The only fish species available was zebrafish, which is more likely to be found in your child’s aquarium! Now, a new salmon gene chip allows researchers to test all kinds of nutritional changes from a nutrigenomics perspective, and already evidence has been generated showing how to reduce the threat of sea lice to salmon.

Scientists have learned how to harness the natural immune system of the fish. Dr. Keith Filer and the research team at Alltech have discovered how to help fish produce more of the mucous-producing cells, making them slimier and thus more difficult for the sea lice to attach. For more on sea lice and the salmon industry, check out “For salmon’s sake: Seeking solutions to sea lice” (primary scientist: Dr. Keith Filer, Alltech).

10. Retooling our approach to Alzheimer’s

From humankind’s perspective, the most important work at Alltech’s nutrigenomics facility is with a selenium compound called AT-001. Nutrigenomic studies have indicated this specific selenium has the ability to change biochemical pathways associated with many serious diseases such as Alzheimer’s or other neurodegenerative diseases.

In collaboration with the late Dr. William Markesbery, the former director at the University of Kentucky’s Sanders-Brown Center on Aging, Alltech began testing AT-001, using a well-established mouse model of Alzheimer’s disease (AD) to evaluate its effects on neurodegeneration.

AT-001 reduced the incidence of clumps of misfolded proteins, known as amyloid plaques, often associated with Alzheimer’s, by 45–50 percent in the brains of these AD mice. Furthermore, the overall destruction caused by oxidative damage in the brain tissue of these same animals was reduced. For example, oxidative damage to both DNA and RNA was reduced by 35 percent and 60 percent, respectively.

Now tested in other animal species and other tissues, AT-001 has been found to significantly increase mitochondrial activity. Mitochondria are the organelles responsible for producing energy in cells and are thus essential for life. It is well documented in scientific literature that even small decreases in mitochondrial activity are linked to the occurrence of at least 50 different illnesses.

These initial results have opened an entirely new field of research, evaluating the physiological impact of more than 100 individual sub-components of AT-001. Three small selenium compounds have displayed remarkable activity in cell culture and animal models with type 2 diabetes. In addition, the compound in AT-001 that is responsible for the reduction in amyloid plaques has been identified and characterized. AT-001 is currently in Phase II human clinical trials in a population of elderly subjects who are at risk of developing AD (primary scientist: Dr. ZJ Lan, Alltech).

The past 10 years have seen incredible scientific and technological advancements in our understanding of nutrigenomics. We believe these breakthroughs are only the beginning as technology and data analytics continue to advance. For humans, animals, and livestock and food producers, the future looks optimistic.

The following is an edited transcript of Luther Andal's interview with Randy Lamontagne, general manager of Cowtown, a retail chain aquired by Alltech. 

Luther:                       Alltech is in the animal feed business, crop business, beverage business, and now, Western wear business. Yes, that’s right: When Alltech acquired Masterfeeds in Canada in 2016, a small retail chain called Cowtown was included. Here to tell us his story, and the Cowtown story, is general manager Randy Lamontagne. Welcome.

Randy:                        Thank you.

Luther:                       Tell us more about Cowtown.

Randy:                         I’d start by saying Cowtown is about a 20,000-square-foot retail store in Regina, Saskatchewan, Canada. We sell Western wear, tack, saddlery, animal health, feed supplies, and pet food and pet supplies.

Luther:                       That’s quite a bit of diversity there. What is the history?

Randy:                         In about 1994, a fellow named Ray Haykel built a feed mill in Regina and started tacking on an office. He decided as he was building the office — he was in construction ­­­­— to expand it a little bit and put in a pet food retail store. Sometime during construction, which I suppose lasted maybe six months or so, he was down in Texas and ran into a big Western wear store. He called home and said, “You know what? Halt the construction. I want to build up a second level and put a Western wear store on top.” He was an entrepreneur with some big dreams, and he just kept dreaming bigger and building as he went. That’s how it started.

Luther:                       Some people may know Cowtown as a Western wear retailer. But, as you’ve pointed out, it didn’t start that way — it’s more diverse than that. Can you give us an idea of products and how they’re used?

Randy:                         I think the biggest thing that makes us successful is the diversity. We’ve got quite a lot of consumables, and when you consider the pet food and the feed for livestock — I use the term “consumables” because it’s something that people need on a frequent basis — and that helps drive Western wear sales. Consumables help drive sales of all the other products that we carry. You might see a typical Western wear customer once every two to three months, for example. But, if they’re buying pet food or feed from you, you can increase the repetition. You increase the frequency of visits to your store, and maybe you’re seeing that same customer two to three times per month instead of once every two to three months. By having that consumable, you also expose them to your clothing lines and some of your other soft-good lines on a more frequent basis. They’ll buy because they see something they like — not so much because they need it, but because they’re buying based on emotion. They may see something they like or see a staff member wearing something they like.

Luther:                       Tell us a little bit about your background — I know it’s an interesting story ­because of where you came from and how you came to be general manager at Cowtown.

Randy:                         It’s a very long story, and I won’t go through it all, but I grew up on a family farm in southeastern Saskatchewan. We had land spread out over two separate areas. We farmed grain, cattle, pigs, chickens and horses. We’re a mixed farming operation.

                                    In the mid-`70s, we bought a service station in our small town — a community of 600 people — right between our two farm areas. We started operating that service station, and my dad decided that we could get more customer traffic if we built onto it. So, we built a grocery store, and then a sporting goods and guns and ammo store was added. Later, we added farm-ag belts and bearings. We just kept building and expanding with opportunities and needs.

                                    So, I kind of grew up in retail. I also worked oil rigs after high school. At one point, I owned a bar and restaurant and a hotel. I’ve sold cars. I took an engineering class and got my power engineering tickets. Just when I was starting a new job in the power engineering career, I happen to meet Ray Haykel in an auto body shop and —  like the old “The Godfather” quote, “I’m going to make you an offer you can’t refuse” — he got me to manage his Western wear store. That was about 21 years ago. I started that, and I found my niche. I really found that what I enjoy is just dealing with people. I find this industry to be down-to-earth. I have a lot of fun with the customers, the staff, everybody. It’s been a great experience.

Luther:                       Let’s bring it back to Cowtown. What’s the breakdown of sales look like with all these different groups?

Randy:                         I would say about 35 percent of the business is on the pet side, about 30 percent is on the Western wear side and the rest is animal health and feed.

Luther:                       Do you tailor the products that you offer in each store based on the location and the community that they’re serving?

Randy:                         Absolutely. You have to get to know your customer and get to know the area you’re in. Any time we start a new store in a new area, we do a little homework, a little research. But then you’re constantly changing and you’re constantly evolving. Your customer, to a certain degree, dictates that. I always ask our staff to keep a notepad by the till. If a customer asks you for something — whether you have it or not is immaterial at that time — write it down. Offer the service or advice. If you don’t have the product that they’re looking for, recommend another option, even if it’s for a competitor. Recommend where they can get it, because you’re still helping that customer. You’re still providing them a service, even if it’s just an answer for where they can get it and even if it’s not from you at the time.

                                    As you make those customer notes on a daily basis, you’ll start to see trends. I’ll pull those notepads from the till every once in a while and check through them myself. When I start seeing the same thing written down two to three times, I think, okay, here’s an opportunity — here’s something our customers are asking for.

Luther:                       It sounds like customer service is a big aspect of Cowtown.

Randy:                         Absolutely. You know what? It’s almost cliché: Everybody says, “Customer service. The customer is number one. The customer is first.” But unless you really believe it and are passionate about it, it’s meaningless. You really have to focus on it. I think in these days, with competition being so fierce for everyone’s hard-earned dollar, shopping to me is almost a form of entertainment.

                                    There are two types of shoppers: There’s the guy that needs something. He knows exactly what he needs. He just wants to get in your store, get his product and get out with no hassle. For the other type of customer, shopping becomes a form of entertainment. They’re looking around, and they’re taking their time. That’s not me. I’m not that guy. I’m more the guy who wants to get in and out and get what I want. But you have to provide an experience for customers.

                                    I’ve always said if you can put a smile on somebody’s face, they’ll remember you. If you can accomplish that, then you get that customer talking about you — talking to his friends and neighbors and recommending you.

Luther:                       It’s becoming increasingly difficult for small businesses to compete against big-box stores. You’ve highlighted the customer service and entertainment aspects. Are those key strategies in competing against the big-box stores? How does Cowtown do it?

Randy:                         In a sense, they are key strategies. You use the term “big-box,” and I like to think outside that box — get outside the box and do things that are creative. I use the term “shock and awe.” I like to look for things that create a little shock and awe. There’s an area in the brain called Broca’s area. It’s about the size of your thumbnail, and it’s kind of the gatekeeper to what makes sense to you or what you’re going to pay attention to or listen to.

                                    I use radio ads heavily. That’s 90 percent of my advertising campaign. It’s intrusive if it’s done right. If you have creative ads that are catchy, and there’s something about the ad that makes you pay attention, that’s shocking the Broca. You can use that in radio ads. You can use that in displays. You can use that all kinds of ways.

                                    For example, a customer asked me one day if I could deliver some product to him. He had bought some Hi-Hog gates — panels for a horse penning he was making. I said, “Sure, I can deliver them. Where do you live?”

                                    He said, “Well, if you’re in west Regina and driving down Highway 11, once you see Exit C, turn right and pull into my lane.” I wasn’t sure where Exit C was. He said, “You live out that way, don’t you?” I did — I lived in Regina Beach at that time. He said, “Well, you’re passing Exit C twice a day, then. There’s a sign: Exit C.”

                                    I drove by that sign every day for probably seven or eight years and never realized there was an Exit C. There’s also an Exit A and an Exit B, but I never paid any attention because I really didn’t care. I had no interest in that. But if I’d seen a deer out in the field, I would take notice of that, and I could tell you where I had seen that deer two days later. That’s shocking the Broca. That deer was not supposed to be there. He’s not there every day.

Luther:                       In terms of bringing that home to maybe a Cowtown ad —  I’m not going to ask you to sing a jingle or anything like that — how do you apply that to a Cowtown ad to make it stand out if it’s a radio ad, for instance?

Randy:                         The biggest thing is that our ad campaign is based on a long-term branding campaign, which is how I like to brand or advertise our products. We don’t advertise sale prices so much — the “our manager is going away” sale or the “Boxing Day” sale — all those phony sales, because that becomes background noise on your radio. It’s no different than the commercial on television when, while you’re watching something you’re interested in, a commercial comes on that doesn’t pique your interest. That’s usually the time you’re taking a washroom break or getting up to grab another beverage, and you just don’t pay attention to it. Radio is no different.

                                    A commercial becomes background noise if it’s like everybody else’s. So, in our campaign, we actually use our mascot —  our spokesperson. It’s a cow. It’s a male. I guess it’s a bull, but his name is actually Cow. He has his own personality, and then there’s a “straight-and-narrow man” that has his own personality. If you’re familiar with hockey in Canada, you know the Don Cherry and Ron MacLean duo, who has one guy who is “out there” and another guy who is more on the straight-and-narrow keeping him in check.

                                    We just have fun with their commercials —  we make people laugh and put a smile on their faces, but all the time you’re branding your business. I always use the example of, if I wanted to put a saddle on sale, I could put an ad in the newspaper and say my saddles are $100 off today. The only guy who is going to see that is the guy who’s actually in the market for a saddle that day. So, I can spend $1,000 on a newspaper ad to try and sell a saddle, but if I’m the customer and I’m flipping through the newspaper, I’ll only stop and look at that ad if I’m interested now. If I’m not interested in it today, I flip right over that page.

                                    Radio is planting the seed on a consistent daily basis with their messages. Consistency is very important — you’re planting the seed for the future so that when that rancher wakes up one morning and decides today is the day to get a new saddle, he says, “I have to go to Cowtown.” That seed has been planted so many times that when he decides he needs a saddle, or a pair of boots, or a pair of jeans, whatever products that we sell, his first thought should be: I have to stop at Cowtown.

Luther:                        So, it sounds to me like what you’re saying with your ads is that you’re entertaining rather than informing.

Randy:                         Yes. Actually, both. I guess you’re informing by entertaining, if that makes sense.

Luther:                       What advice would you give to smaller businesses that are more localized retailers and they’re attempting to compete with the big-box stores out there?

Randy:                         To me, passion is the key. If you’re not passionate about the business, get out of it. Don’t fool yourself. You also need a proper business plan. You need to be committed going into it. We have a bit of a unique store. When people are around it, people come and see our store and they get involved a little bit. There’s a draw and a little bit of a love of the industry. We’ll have people actually come to us and say, “Hey, I’d like to do a Cowtown franchise” or “I’d like to start a store.”

                                    Okay. What’s making them think that? They’ll say, “Well, I see you guys selling lots of stuff at these trade shows.” Or, “I come into your store, and it’s busy, and everybody is happy and things are fun, and you have Western wear.” And, “I know people that have horses. We have friends who have horses, and we’d like to start a store.”

                                    Well, that’s not a real business plan, you know? It’s not that easy. You have to live it, breathe it, eat it, sleep it and think it nonstop. You have those people who are passionate about it in that way.

Luther:                       How is Cowtown responding to the move to digital for many retailers out there? Customers are online, shopping from mobile devices, researching through mobile devices. How is Cowtown responding to that, or do you see your customers moving to digital, or are they still preferring that in-store experience that you offer?

Randy:                         I think there’s probably some of both (preference for digital and in-store experiences) going on in the industry, and there’s room for both. I think customers are getting more savvy as far as researching products online, but I feel like they still want the experience of coming into the store and dealing with a person — not a website or someone on the phone. They like the personal contact.

                                    If you’re coming in to buy a saddle or a pair of boots, you want to make sure they fit. Yes, you can order them over the internet, but there’s a good chance that they’re not going fit properly when you get them and then you’re going to send them back. Or, you can come into our store and get personal attention and have someone fit a boot to your foot properly.

                                    So, I think there’s room for both (digital and in-store experiences) in our industry. We’re starting to use Facebook, Twitter and our website for more interaction with the customer. It still boils down to interaction with the customer. Ultimately, we hope that (digital) leads the customer to visit our store because that’s where we can make the biggest impression: one-on-one with the customer.

Luther:                        How many locations is Cowtown in currently?

Randy:                         We’re in seven right now. We’ve been growing in the last few years. We started with the one store in Regina when Masterfeeds bought us in 2001. We weren’t part of the core business for Masterfeeds. They were a 75-year-old feed company at the time of the acquisition. I don’t think it was originally in the plans for Masterfeeds to have a retail store. So, we needed to prove ourselves, and they gave us that opportunity and that chance. When I first came to Cowtown, I remember looking at that business, and to me, it was like seeing opportunity in blinking Vegas lights. That’s how I see this business —  there was so much opportunity to grow this. We got a couple years under our belts with Masterfeeds, and they gave us that chance to grow, and now we’re seven stores and growing. Now with Alltech behind us, I see huge opportunity for growth again.

Luther:                       Well, speaking of growth, what other things do you think the future holds for Cowtown? Is it just growth? Is it different products? Is it digital?

Randy:                         Yeah. I suppose all of the above. I really do see opportunities for everything there.

                                    Just in our own area, we have plans for stores in other markets where we think we can really serve the markets we know well. Overseas, I think there’s huge opportunity for growth in stores. We’ve sold overseas for a number of years now. We’ve sold to people in Australia, for example. And usually, it starts with, again, that personal contact. You get some young guys visiting from Australia on the rodeo circuit. At some point, they get to our store and they buy jeans or boots. When they get home, they start telling people in Australia about us, about our store. Then we get calls and we end up shipping stuff to Australia. Again, it was from that original personal contact — making that first impression with the customer. So, I think there’s opportunity to grow overseas, possibly down here in the States and definitely back home in Canada. The website will, of course, become a bigger tool. Digital media is going to become bigger for us in the future. This is my first kick at a podcast. I’ve heard about them but never knew what one was until today.

Luther:                        Well, welcome to the podcast.

Randy:                         There you go. Yeah!

Luther:                        What’s something that you wish customers knew about Cowtown?

Randy:                         I just hope to instill in every customer who comes in the door that we’re passionate about our business and we’re passionate about our customers. We look to make relationships with our customers — relational sales versus transactional sales. There’s always going be that transactional sale for the customer who comes in and just buys a pair of jeans because they happen to be there. But long-term relationships are what keep customers coming back and what keeps customers coming to your store rather than the next store.

                                    If I look at our pet food category — that’s one that everybody is in. You can buy pet food from a big-box pet store, from a grocery store, service station, Walmart, Costco or Canadian Tire. Everybody is in that market, yet it’s our fastest-growing sector of the business at Cowtown. I firmly believe it’s because we go the extra mile, we pay attention to our customers and we try to get to know our customers to the point of getting to know their dogs or their cats. When that customer walks in and he’s got Sparky on a leash and you acknowledge the dog and give the dog a treat, it’s like picking their kid up and giving them a hug. That pet is part of the family, and it really becomes personal.

Luther:                        Randy Lamontagne is the general manager of Cowtown, a retailer with seven locations in southern Saskatchewan, Manitoba and Alberta, Canada.

There are two important parts to free stalls. One is the neck rail. The purpose of the neck rail is that, when a cow stands up, the rail positions her so that it touches the top of her shoulder, guiding her to back up a couple of inches so she will defecate in the ally.

The next important part of the free stall is the brisket locator. The brisket locator positions the cow so that she doesn’t lie down too far forward in the stall.

When we measure stalls, we want to see stalls that are long and wide. Today, we have bigger cows, especially when we consider the Holstein breed. Our goal is to see stalls that, when measured from curb to curb, are between 17–18 feet wide to allow personal space for the cows. When measuring stall width, we measure what the cow feels. We do not measure from the center of the loop to the center of the next loop; we measure from inside to inside of the loop. With our bigger cows, we should be around 50 inches, not at 45 inches, which I see in many barns. For these larger cows, the neck rail should be around 50 inches high as well.

Next, we want to avoid obstruction. Horizontal obstructions are often seen in older barns and affect the cow’s ability to get straight up and straight down. If we watch a cow out in the pasture as she gets up naturally, she rocks her head forward toward the ground, puts one front foot forward, planting herself to stand up straight. When obstructions are in their “rising,” they will do everything they can to use the valuable inches of space. I like to say that cows know geometry — they figure out how to use angles in the stall to get the most use out of the space they are provided. If the stall is too narrow, or too short, the cow will naturally angle herself in the stall.

If we see cows standing with two feet in the stall and two feet out of the stall, we call that “perching,” and this is not good. We want the cows to come into the stall and lie down immediately. We want them off their feet because these are 1,400- to 1,600-pound animals. They should be comfortable and lying down because more blood is pumped through the udder to make milk when they are lying down versus standing up.

Cow comfort

When considering stall design, we need to be sure to look directly at the cows themselves. When you look at a cow, you want to see a very nice set of feet and legs. While in the parlor, if I see swollen hocks, skinned hocks or injuries on the inside of the leg of the animal, that tells me that the stalls are too short and too narrow and the type of surface that the cow is lying on may be having a negative effect on her legs. Consider yourself: If you’re in a hotel and the bed is not comfortable, what do you do? You toss and you turn. When a 1,400- to 1,600-pound animal is not comfortable in the stall, she is moving her legs, tossing and turning in the stall, leading to swollen and skinned hocks.

When we see an injury on the inside of the leg, that tells me that the stall is too short and her leg is hanging over the curb.

These are very important aspects of cow comfort that we can observe in the parlor before we even look at the cow in the free stalls.

Water quality

When we talk about overall milk quality and cow comfort, another critical component is water. Over 87 percent of milk composition is water.

When I am looking at the stalls, I also spend time examining the waterers. Are the waterers clean and scrubbed? Are we doing a good job of protecting the waterers?

I always like to see a high rail around the water so cows can’t jump up and put their feet in the waterer. We want the distance between the edge of the water and the edge of the wall to be over 12 feet so the “big boss” cows can be drinking water and other cows can go around behind them to eat and lie down. Plenty of clean water is very important, and it must be enough for the number of cows. Cows can consume between 30–50 gallons of water per day. Providing enough available space of water for the number of cows, approximately 3 feet of available water area per 10–15 cows, is important to milk production.

Air quality

Air quality, or the movement of air over the cows, is another very important part of cow comfort in a free stall building, a cross-ventilated building and a natural-ventilated building. 

When measuring stalls, I check what the wind speed is, or how good the air quality is moving through the building. Smoke is a great tool for showing the air movement through the building, but cows do not like smoke and can smell it up to 5 miles away. So, instead of smoke, I go to my grandkids’ toy box and find a little bubble machine. This little bubble machine gives me a good indication of which way and how fast the airflow is moving in the building. Plus, the curious cows seem amused by the bubbles!

Alltech’s new brewery and distillery project rolls toward spring 2018 completion

[PIKEVILLE, Ky.] – Beneath the picturesque backdrop of the storied Appalachian Mountains, progress continues at Alltech’s Dueling Barrels Brewery & Distillery in downtown Pikeville, Kentucky. Marking the latest milestone, Eastern Kentucky native Danny Branham has been appointed general manager, overseeing the region’s first (legal) bourbon, beer and moonshine operation.    

Branham has been with Alltech for nearly eight years, often traveling far from his hometown of Pikeville. At Alltech’s facilities in Tianjin and Beijing, China, Branham was instrumental in streamlining quality and production processes. He also earned his master’s degree in brewing and distilling from Heriot-Watt University in Scotland. Since returning to the U.S., Branham has served as quality manager for Alltech’s beverage division.

“I think what I am most excited about is the opportunity to return home and be involved in a project that will put Pikeville on the map as one of the premier destinations in Kentucky to visit and experience the art of brewing and distilling,” said Branham.

In addition to distilled spirits, Dueling Barrels will offer visitors a taste of rich Appalachian culture as they explore stories of mountain music, family feuds and the resilient immigrants who shaped the region.

Dueling Barrels is the latest endeavour in the continued global expansion of the Alltech Beverage Division. Alltech founders Pearse and Deirdre Lyons feel a special kinship with the mountains, craftsmanship and hardworking people of Appalachia. After immigrating to Kentucky from Ireland, they developed a strong affinity for the region and sought an opportunity to invest in its development. It is their hope that the distillery destination will extend the Kentucky Bourbon Trail^® tour into Eastern Kentucky.

“Dueling Barrels has the potential to bring in lots of visitors to the area and increase revenues for all businesses through tourism,” said Branham.

The next milestone will be the commission and operation of the brewhouse and distillery, slated for January 2018, which will keep Dueling Barrels on track to open in spring 2018.

The impact that heat stress can have on a herd, as we all know, can be substantial. When looking at a lactating herd, it is critical to find ways to minimize the effects of heat. But one vital area of the farm that is affected by heat is sometimes overlooked: calves can be extremely susceptible to higher temperatures due to their smaller body mass and higher respiration rate.

Calves and lactating cows experience heat stress at different levels. For a mature lactating animal, the level at which they begin to experience heat stress is at around 60 degrees Fahrenheit and is lower in humid environments. In contrast, calves start feeling heat stress around 75-80 degrees Fahrenheit. In the summer sun, calves look for relief in their hutches, but sometimes the hutch environment can be even hotter and more humid than the outside environment.

By managing the following three key areas, producers can ensure that their calves stay cool and healthy during the hottest time of the year.

Drink up: Keep calves hydrated

Though it might seem obvious, ensuring calves have an adequate water supply that is fresh and clean can be a key factor in helping to prevent dehydration. Dehydration can be particularly dangerous during times of gastrointestinal stress, which can hinder a calf’s rate of recovery.

Water acidifiers have been shown to increase water consumption because they make the water more palatable to the calves, which encourages them to drink more.

Shoo, fly — don’t bother the calves!

Hot temperatures go hand in hand with flies. It is extremely important to control flies in the calf’s environment, as flies are a main offender when it comes to transferring dangerous bacteria throughout the herd. Illnesses such as pink eye are known to be spread by flies. Recent research has also shown that flies can be carriers of some strains of Salmonella, which can show up later in life as a cause of mastitis at first lactation.

Common fly control methods include an Insect Growth Regulator (IGR) in the feed as well as treating and spraying around hutches with chemicals labeled to assist in fly control.

Easy, breezy temperature maintenance

Adequate ventilation is important for calves, especially if they are kept inside an enclosed area or barn. Some operations may have a more serious ventilation issue when using automatic feeders because the bedding can be more prone to moisture.

Ensuring the bedding remains clean and dry is critical to calf health and longevity. As temperatures rise, ammonia levels tend to rise as well, and wet bedding can pose a serious threat to calves as a result. Utilizing an ammonia binding product can be helpful.

De-Odorase®, a product from Alltech, is commonly utilized in calf barns to control ammonia issues.

Adequate ventilation is also important in the hutch. One key component to hutch ventilation is keeping vents open during the day, as hutches can get too hot if vents are closed. What many people don’t think about in the summer, though, is that hutches can also get too cold on cool evenings if the vents are not closed at night. This is particularly concerning in the summer because usually less bedding is used during this time, and a cold front can be hard on the less protected calves, especially when they are younger.

Heat stress can affect herds in many ways. Herd longevity and the future of operations depend on the health of calves, who rely on farm owners and managers taking the necessary steps to ensure they remain healthy during the summer. 

Have a question or comment?